Quercetin nanoformulation-embedded hydrogel inhibits osteopontin mediated ferroptosis for intervertebral disc degeneration alleviation

Quercetin nanoformulation-embedded hydrogel inhibits osteopontin mediated ferroptosis for intervertebral disc degeneration alleviation

Abstract Reactive oxygen species (ROS) play a pivotal role in multiple events during the progression of intervertebral disc degeneration (IDD). Hence, the precision treatment targets associated with ROS should be further explored to promote developing effective therapeutic strategies. In this study,...

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Main Authors: Jitian Li, Lemeng Ren, Lei Wan, Man Liu, Mingyu Zhao, Yazhou Lin, Jiancheng Zheng, Yun Tang, Yage Luo, Yan Ma, Lei Wang, Peng Cao, Zhe Chen, Wenjie Ren, Fei Wang
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Journal of Nanobiotechnology
Subjects:
Intervertebral disc degeneration
Quercetin
Osteopontin
Ferroptosis
Injectable hydrogel
Online Access:https://doi.org/10.1186/s12951-025-03574-w
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