Association between circulatory complement activation and hypertensive renal damage: a case–control study
Objective The aim of this study was to investigate the potential importance of complement system activation, with particular emphasis on the complement alternative pathway (AP), in the pathogenesis of hypertensive renal damage.Methods Serum complement C3, complement Factor H (CFH) and AP activation...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2024-12-01
|
| Series: | Renal Failure |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/0886022X.2024.2365396 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849763039404883968 |
|---|---|
| author | Zhongli Wang Tingting Zhang Xinyu Wang Jianlong Zhai Lili He Sai Ma Qingjuan Zuo Guorui Zhang Yifang Guo |
| author_facet | Zhongli Wang Tingting Zhang Xinyu Wang Jianlong Zhai Lili He Sai Ma Qingjuan Zuo Guorui Zhang Yifang Guo |
| author_sort | Zhongli Wang |
| collection | DOAJ |
| description | Objective The aim of this study was to investigate the potential importance of complement system activation, with particular emphasis on the complement alternative pathway (AP), in the pathogenesis of hypertensive renal damage.Methods Serum complement C3, complement Factor H (CFH) and AP activation were assessed in 66 participants with established essential hypertension with renal damage (RD). Fifty-nine patients with age- and sex-matched essential hypertension without renal damage (NRD) and 58 healthy participants (normal) were selected.Results Our study revealed that C3 and AP50 continuously increased from normal to NRD to RD (p < 0.05, respectively), while CFH was significantly lower than that in NRD and healthy participants (p < 0.05, respectively). After multifactorial logistic regression analysis corrected for confounders, elevated serum C3 (p = 0.001) and decreased CFH (p < 0.001) were found to be independent risk factors for hypertension in healthy participants; elevated serum C3 (p = 0.034), elevated AP50 (p < 0.001), decreased CFH (p < 0.001), increased age (p = 0.011) and increased BMI (p = 0.013) were found to be independent risk factors for the progression of hypertension to hypertensive renal damage; elevated serum C3 (p = 0.017), elevated AP50 (p = 0.023), decreased CFH (p = 0.005) and increased age (p = 0.041) were found to be independent risk factors for the development of hypertensive renal damage in healthy participants.Conclusion Abnormal activation of complement, particularly complement AP, may be a risk factor for the development and progression of hypertensive renal damage. |
| format | Article |
| id | doaj-art-3ae8cd875aaa4a5793f5b4afb573a1ab |
| institution | DOAJ |
| issn | 0886-022X 1525-6049 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj-art-3ae8cd875aaa4a5793f5b4afb573a1ab2025-08-20T03:05:33ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492024-12-0146210.1080/0886022X.2024.2365396Association between circulatory complement activation and hypertensive renal damage: a case–control studyZhongli Wang0Tingting Zhang1Xinyu Wang2Jianlong Zhai3Lili He4Sai Ma5Qingjuan Zuo6Guorui Zhang7Yifang Guo8Department of Physical Examination Center, Hebei General Hospital, Shijiazhuang, Hebei, ChinaDepartment of Geriatric Cardiology, Hebei General Hospital, Shijiazhuang, Hebei, ChinaCollege of Postgraduate, Hebei North University, Zhangjiakou, Hebei, ChinaDepartment of Cardiology, Hebei General Hospital, Shijiazhuang, Hebei, ChinaDepartment of Geriatric Cardiology, Hebei General Hospital, Shijiazhuang, Hebei, ChinaDepartment of Internal Medicine, Hebei General Hospital, Shijiazhuang, Hebei, ChinaDepartment of Geriatric Cardiology, Hebei General Hospital, Shijiazhuang, Hebei, ChinaDepartment of Cardiology, The Third Hospital of Shijiazhuang City Affiliated to Hebei Medical University, Shijiazhuang, Hebei, ChinaDepartment of Geriatric Cardiology, Hebei General Hospital, Shijiazhuang, Hebei, ChinaObjective The aim of this study was to investigate the potential importance of complement system activation, with particular emphasis on the complement alternative pathway (AP), in the pathogenesis of hypertensive renal damage.Methods Serum complement C3, complement Factor H (CFH) and AP activation were assessed in 66 participants with established essential hypertension with renal damage (RD). Fifty-nine patients with age- and sex-matched essential hypertension without renal damage (NRD) and 58 healthy participants (normal) were selected.Results Our study revealed that C3 and AP50 continuously increased from normal to NRD to RD (p < 0.05, respectively), while CFH was significantly lower than that in NRD and healthy participants (p < 0.05, respectively). After multifactorial logistic regression analysis corrected for confounders, elevated serum C3 (p = 0.001) and decreased CFH (p < 0.001) were found to be independent risk factors for hypertension in healthy participants; elevated serum C3 (p = 0.034), elevated AP50 (p < 0.001), decreased CFH (p < 0.001), increased age (p = 0.011) and increased BMI (p = 0.013) were found to be independent risk factors for the progression of hypertension to hypertensive renal damage; elevated serum C3 (p = 0.017), elevated AP50 (p = 0.023), decreased CFH (p = 0.005) and increased age (p = 0.041) were found to be independent risk factors for the development of hypertensive renal damage in healthy participants.Conclusion Abnormal activation of complement, particularly complement AP, may be a risk factor for the development and progression of hypertensive renal damage.https://www.tandfonline.com/doi/10.1080/0886022X.2024.2365396Complement systemhypertensive renal damagecomplement C3alternative complement pathway (AP)CFH |
| spellingShingle | Zhongli Wang Tingting Zhang Xinyu Wang Jianlong Zhai Lili He Sai Ma Qingjuan Zuo Guorui Zhang Yifang Guo Association between circulatory complement activation and hypertensive renal damage: a case–control study Renal Failure Complement system hypertensive renal damage complement C3 alternative complement pathway (AP) CFH |
| title | Association between circulatory complement activation and hypertensive renal damage: a case–control study |
| title_full | Association between circulatory complement activation and hypertensive renal damage: a case–control study |
| title_fullStr | Association between circulatory complement activation and hypertensive renal damage: a case–control study |
| title_full_unstemmed | Association between circulatory complement activation and hypertensive renal damage: a case–control study |
| title_short | Association between circulatory complement activation and hypertensive renal damage: a case–control study |
| title_sort | association between circulatory complement activation and hypertensive renal damage a case control study |
| topic | Complement system hypertensive renal damage complement C3 alternative complement pathway (AP) CFH |
| url | https://www.tandfonline.com/doi/10.1080/0886022X.2024.2365396 |
| work_keys_str_mv | AT zhongliwang associationbetweencirculatorycomplementactivationandhypertensiverenaldamageacasecontrolstudy AT tingtingzhang associationbetweencirculatorycomplementactivationandhypertensiverenaldamageacasecontrolstudy AT xinyuwang associationbetweencirculatorycomplementactivationandhypertensiverenaldamageacasecontrolstudy AT jianlongzhai associationbetweencirculatorycomplementactivationandhypertensiverenaldamageacasecontrolstudy AT lilihe associationbetweencirculatorycomplementactivationandhypertensiverenaldamageacasecontrolstudy AT saima associationbetweencirculatorycomplementactivationandhypertensiverenaldamageacasecontrolstudy AT qingjuanzuo associationbetweencirculatorycomplementactivationandhypertensiverenaldamageacasecontrolstudy AT guoruizhang associationbetweencirculatorycomplementactivationandhypertensiverenaldamageacasecontrolstudy AT yifangguo associationbetweencirculatorycomplementactivationandhypertensiverenaldamageacasecontrolstudy |