Estimating the causal influence of body mass index on risk of Parkinson disease: A Mendelian randomisation study.

Estimating the causal influence of body mass index on risk of Parkinson disease: A Mendelian randomisation study.

<h4>Background</h4>Both positive and negative associations between higher body mass index (BMI) and Parkinson disease (PD) have been reported in observational studies, but it has been difficult to establish causality because of the possibility of residual confounding or reverse causation...

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Main Authors: Alastair J Noyce, Demis A Kia, Gibran Hemani, Aude Nicolas, T Ryan Price, Eduardo De Pablo-Fernandez, Philip C Haycock, Patrick A Lewis, Thomas Foltynie, George Davey Smith, International Parkinson Disease Genomics Consortium, Anette Schrag, Andrew J Lees, John Hardy, Andrew Singleton, Mike A Nalls, Neil Pearce, Debbie A Lawlor, Nicholas W Wood
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-06-01
Series:PLoS Medicine
Online Access:https://doi.org/10.1371/journal.pmed.1002314
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