NOVEL AZOLYLALKYLTHIO, -SULFOXY, AND -SULFONYL COMPOUNDS WITH ANTIPICORNAVIRAL ACTIVITY
A novel series of azolylalkylthio, -sulfoxy, and-sulfonyl compounds was designed, synthesized, and evaluated for antipicornaviral activity. Two compounds (4i and 4 1) exhibited significant activity against various serotypes of human rhinovirus (HRV). It was found that incorporation of hydrophobic az...
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| Language: | English |
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University of Tehran
1997-03-01
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| Series: | Journal of Sciences, Islamic Republic of Iran |
| Online Access: | https://jsciences.ut.ac.ir/article_31140_9af6439006d2aa3de37ca19f4d4edde4.pdf |
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| collection | DOAJ |
| description | A novel series of azolylalkylthio, -sulfoxy, and-sulfonyl compounds was designed,
synthesized, and evaluated for antipicornaviral activity. Two compounds (4i and 4 1)
exhibited significant activity against various serotypes of human rhinovirus (HRV).
It was found that incorporation of hydrophobic azoles such as 3-methylisoxazole or
4-methylthiazole led to increased activity. In addition, activity markedly improved
when the size of the thio substituent was increased. oxidation of the thio derivatives
to the corresponding sulfoxides and sulfones resulted in less active compounds. 2-[6-
[(5- chlorobenzimidazol-2-yl)thio]hexyl]-4-methylthiazole (4 1) was found to exhibit activity against HRV comparable tb Disoxaril, and was also effective against the Coxsackie B 1 virus |
| format | Article |
| id | doaj-art-3adf2e32fbd6432abdab429ed1756525 |
| institution | OA Journals |
| issn | 1016-1104 2345-6914 |
| language | English |
| publishDate | 1997-03-01 |
| publisher | University of Tehran |
| record_format | Article |
| series | Journal of Sciences, Islamic Republic of Iran |
| spelling | doaj-art-3adf2e32fbd6432abdab429ed17565252025-08-20T02:25:51ZengUniversity of TehranJournal of Sciences, Islamic Republic of Iran1016-11042345-69141997-03-018131140NOVEL AZOLYLALKYLTHIO, -SULFOXY, AND -SULFONYL COMPOUNDS WITH ANTIPICORNAVIRAL ACTIVITYA novel series of azolylalkylthio, -sulfoxy, and-sulfonyl compounds was designed, synthesized, and evaluated for antipicornaviral activity. Two compounds (4i and 4 1) exhibited significant activity against various serotypes of human rhinovirus (HRV). It was found that incorporation of hydrophobic azoles such as 3-methylisoxazole or 4-methylthiazole led to increased activity. In addition, activity markedly improved when the size of the thio substituent was increased. oxidation of the thio derivatives to the corresponding sulfoxides and sulfones resulted in less active compounds. 2-[6- [(5- chlorobenzimidazol-2-yl)thio]hexyl]-4-methylthiazole (4 1) was found to exhibit activity against HRV comparable tb Disoxaril, and was also effective against the Coxsackie B 1 virushttps://jsciences.ut.ac.ir/article_31140_9af6439006d2aa3de37ca19f4d4edde4.pdf |
| spellingShingle | NOVEL AZOLYLALKYLTHIO, -SULFOXY, AND
-SULFONYL COMPOUNDS WITH
ANTIPICORNAVIRAL ACTIVITY Journal of Sciences, Islamic Republic of Iran |
| title | NOVEL AZOLYLALKYLTHIO, -SULFOXY, AND
-SULFONYL COMPOUNDS WITH
ANTIPICORNAVIRAL ACTIVITY |
| title_full | NOVEL AZOLYLALKYLTHIO, -SULFOXY, AND
-SULFONYL COMPOUNDS WITH
ANTIPICORNAVIRAL ACTIVITY |
| title_fullStr | NOVEL AZOLYLALKYLTHIO, -SULFOXY, AND
-SULFONYL COMPOUNDS WITH
ANTIPICORNAVIRAL ACTIVITY |
| title_full_unstemmed | NOVEL AZOLYLALKYLTHIO, -SULFOXY, AND
-SULFONYL COMPOUNDS WITH
ANTIPICORNAVIRAL ACTIVITY |
| title_short | NOVEL AZOLYLALKYLTHIO, -SULFOXY, AND
-SULFONYL COMPOUNDS WITH
ANTIPICORNAVIRAL ACTIVITY |
| title_sort | novel azolylalkylthio sulfoxy and sulfonyl compounds with antipicornaviral activity |
| url | https://jsciences.ut.ac.ir/article_31140_9af6439006d2aa3de37ca19f4d4edde4.pdf |