Diffusivity alterations related to cognitive performance and phenylalanine levels in early-treated adults with phenylketonuria

Diffusivity alterations related to cognitive performance and phenylalanine levels in early-treated adults with phenylketonuria

Abstract Background Altered white matter (WM) is consistently reported in patients with phenylketonuria (PKU). However, the knowledge about WM microstructural integrity in early-treated adults with classical PKU and its relationship with cognition and metabolic parameters is inconclusive. This study...

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Bibliographic Details
Main Authors: Jèssica Pardo, Clara Capdevila-Lacasa, Bàrbara Segura, Adriana Pané, Pedro J. Moreno, Glòria Garrabou, Josep M. Grau-Junyent, Carme Junqué, Consortium PKU.cat
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Journal of Neurodevelopmental Disorders
Subjects:
Phenylketonuria
Neuropsychological performance
Diffusion tensor imaging
Cerebral white matter
Dietary control
Online Access:https://doi.org/10.1186/s11689-025-09622-8
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