The Use of FTIR-ATR Spectrometry for Evaluation of Surgical Resection Margin in Colorectal Cancer: A Pilot Study of 56 Samples
Colorectal cancer is one of the most common malignancies in human, and it is also one of the most leading causes of cancer-related death. Recently, Fourier transform infrared (FTIR) spectrometry is considered to develop into a new method for cancer diagnosis. In this study, colorectal cancer and muc...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Journal of Spectroscopy |
| Online Access: | http://dx.doi.org/10.1155/2014/213890 |
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| author | Hongwei Yao Xueying Shi Yuanfu Zhang |
| author_facet | Hongwei Yao Xueying Shi Yuanfu Zhang |
| author_sort | Hongwei Yao |
| collection | DOAJ |
| description | Colorectal cancer is one of the most common malignancies in human, and it is also one of the most leading causes of cancer-related death. Recently, Fourier transform infrared (FTIR) spectrometry is considered to develop into a new method for cancer diagnosis. In this study, colorectal cancer and mucosa 1 cm, 2 cm, and 5 cm away from tumor were measured by FTIR spectroscopy. FTIR spectra of colorectal cancer and mucosa 1 cm away from tumor were different from those of mucosa 2 cm and 5 cm away from tumor. According to the analysis of FTIR spectrometry, the decrease of lipid and the increase of protein and nucleic acid were observed in the former two sites. FTIR spectrometry, therefore, may be developed into a rapid promising method for judging surgical resection margin of colorectal cancer. |
| format | Article |
| id | doaj-art-3addcacf89cc4e5a844890d37a5d09af |
| institution | OA Journals |
| issn | 2314-4920 2314-4939 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Spectroscopy |
| spelling | doaj-art-3addcacf89cc4e5a844890d37a5d09af2025-08-20T02:08:02ZengWileyJournal of Spectroscopy2314-49202314-49392014-01-01201410.1155/2014/213890213890The Use of FTIR-ATR Spectrometry for Evaluation of Surgical Resection Margin in Colorectal Cancer: A Pilot Study of 56 SamplesHongwei Yao0Xueying Shi1Yuanfu Zhang2Department of General Surgery, Peking University Third Hospital, Beijing 100191, ChinaDepartment of Pathology, School of Basic Medical Sciences, Peking University Third Hospital, Beijing 100191, ChinaCollege of Chemistry and Molecular Engineering, State Key Laboratory of Rare Earth Material Chemistry and Application, Peking University, Beijing 100871, ChinaColorectal cancer is one of the most common malignancies in human, and it is also one of the most leading causes of cancer-related death. Recently, Fourier transform infrared (FTIR) spectrometry is considered to develop into a new method for cancer diagnosis. In this study, colorectal cancer and mucosa 1 cm, 2 cm, and 5 cm away from tumor were measured by FTIR spectroscopy. FTIR spectra of colorectal cancer and mucosa 1 cm away from tumor were different from those of mucosa 2 cm and 5 cm away from tumor. According to the analysis of FTIR spectrometry, the decrease of lipid and the increase of protein and nucleic acid were observed in the former two sites. FTIR spectrometry, therefore, may be developed into a rapid promising method for judging surgical resection margin of colorectal cancer.http://dx.doi.org/10.1155/2014/213890 |
| spellingShingle | Hongwei Yao Xueying Shi Yuanfu Zhang The Use of FTIR-ATR Spectrometry for Evaluation of Surgical Resection Margin in Colorectal Cancer: A Pilot Study of 56 Samples Journal of Spectroscopy |
| title | The Use of FTIR-ATR Spectrometry for Evaluation of Surgical Resection Margin in Colorectal Cancer: A Pilot Study of 56 Samples |
| title_full | The Use of FTIR-ATR Spectrometry for Evaluation of Surgical Resection Margin in Colorectal Cancer: A Pilot Study of 56 Samples |
| title_fullStr | The Use of FTIR-ATR Spectrometry for Evaluation of Surgical Resection Margin in Colorectal Cancer: A Pilot Study of 56 Samples |
| title_full_unstemmed | The Use of FTIR-ATR Spectrometry for Evaluation of Surgical Resection Margin in Colorectal Cancer: A Pilot Study of 56 Samples |
| title_short | The Use of FTIR-ATR Spectrometry for Evaluation of Surgical Resection Margin in Colorectal Cancer: A Pilot Study of 56 Samples |
| title_sort | use of ftir atr spectrometry for evaluation of surgical resection margin in colorectal cancer a pilot study of 56 samples |
| url | http://dx.doi.org/10.1155/2014/213890 |
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