Relationship Between Human Microbiome and <em>Helicobacter pylori</em>
The enteric microbiota influences gene expression in the colonic epithelium. <i>H. pylori</i> (Helicobacter pylori) affects gastric growth factors, cytokines, and tumor cell markers, potentially benefiting the host. The interaction between <i>H. pylori</i> and human microbiot...
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2025-01-01
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| author | Giada La Placa Marcello Covino Marcello Candelli Antonio Gasbarrini Francesco Franceschi Giuseppe Merra |
| author_facet | Giada La Placa Marcello Covino Marcello Candelli Antonio Gasbarrini Francesco Franceschi Giuseppe Merra |
| author_sort | Giada La Placa |
| collection | DOAJ |
| description | The enteric microbiota influences gene expression in the colonic epithelium. <i>H. pylori</i> (Helicobacter pylori) affects gastric growth factors, cytokines, and tumor cell markers, potentially benefiting the host. The interaction between <i>H. pylori</i> and human microbiota is complex but appears beneficial in gastric disease development. This publication discusses the human microbiota, gastric microbiome, chronic <i>H. pylori</i> colonization, and the bacterium’s role in gastric disease. The interplay between the gastric bacterium and human microbiota during infection is also explored. The human gut has the most abundant and complex microbial community and performs vital roles in food digestion and nutrient uptake, extraction of absorbable vitamins, and inhibition of pathogen colonization. <i>Helicobacter pylori</i> is a highly specialized human gastric pathogen, predominantly colonizing the gastric mucus layer, on or adherent to the underlying gastric epithelial cell surfaces. Many studies have suggested that the gastric microbiome is related to <i>H. pylori</i> infection, and some bacterial species can be used for the detection or diagnosis of <i>H. pylori</i> infection. Human microbiome and genome analysis has revolutionized our understanding of the intricate relationship between humans and their associated microbial communities. The integration of microbiome data has displayed promising capabilities in occult disease detection, unveiling previously hidden pathologies and providing opportunities for early intervention. These groundbreaking discoveries have paved the way for novel therapeutic strategies and a deeper comprehension of the interconnected nature of the human microbiome and overall health. |
| format | Article |
| id | doaj-art-3adb43afecdb40ab8d04c1dcabaec768 |
| institution | DOAJ |
| issn | 2036-7481 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
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| spelling | doaj-art-3adb43afecdb40ab8d04c1dcabaec7682025-08-20T02:43:13ZengMDPI AGMicrobiology Research2036-74812025-01-011612410.3390/microbiolres16010024Relationship Between Human Microbiome and <em>Helicobacter pylori</em>Giada La Placa0Marcello Covino1Marcello Candelli2Antonio Gasbarrini3Francesco Franceschi4Giuseppe Merra5Ph.D. School of Applied Medical-Surgical-Sciences, Univeristy of Rome Tor Vergata, 00133 Rome, ItalyDepartment of Emergency Medicine, “A. Gemelli” General Hospital Foundation IRCCS, Catholic University of Sacred Heart, 00135 Rome, ItalyDepartment of Emergency Medicine, “A. Gemelli” General Hospital Foundation IRCCS, Catholic University of Sacred Heart, 00135 Rome, ItalyDepartment of Medical and Surgical Sciences, “A. Gemelli” General Hospital Foundation IRCCS, Catholic University of Sacred Heart, 00135 Rome, ItalyDepartment of Emergency Medicine, “A. Gemelli” General Hospital Foundation IRCCS, Catholic University of Sacred Heart, 00135 Rome, ItalyDepartment of Biomedicine and Prevention, University of Rome Tor Vergata, 00133 Rome, ItalyThe enteric microbiota influences gene expression in the colonic epithelium. <i>H. pylori</i> (Helicobacter pylori) affects gastric growth factors, cytokines, and tumor cell markers, potentially benefiting the host. The interaction between <i>H. pylori</i> and human microbiota is complex but appears beneficial in gastric disease development. This publication discusses the human microbiota, gastric microbiome, chronic <i>H. pylori</i> colonization, and the bacterium’s role in gastric disease. The interplay between the gastric bacterium and human microbiota during infection is also explored. The human gut has the most abundant and complex microbial community and performs vital roles in food digestion and nutrient uptake, extraction of absorbable vitamins, and inhibition of pathogen colonization. <i>Helicobacter pylori</i> is a highly specialized human gastric pathogen, predominantly colonizing the gastric mucus layer, on or adherent to the underlying gastric epithelial cell surfaces. Many studies have suggested that the gastric microbiome is related to <i>H. pylori</i> infection, and some bacterial species can be used for the detection or diagnosis of <i>H. pylori</i> infection. Human microbiome and genome analysis has revolutionized our understanding of the intricate relationship between humans and their associated microbial communities. The integration of microbiome data has displayed promising capabilities in occult disease detection, unveiling previously hidden pathologies and providing opportunities for early intervention. These groundbreaking discoveries have paved the way for novel therapeutic strategies and a deeper comprehension of the interconnected nature of the human microbiome and overall health.https://www.mdpi.com/2036-7481/16/1/24human microbiota<i>Helicobacter pylori</i>gutgastricgenome |
| spellingShingle | Giada La Placa Marcello Covino Marcello Candelli Antonio Gasbarrini Francesco Franceschi Giuseppe Merra Relationship Between Human Microbiome and <em>Helicobacter pylori</em> Microbiology Research human microbiota <i>Helicobacter pylori</i> gut gastric genome |
| title | Relationship Between Human Microbiome and <em>Helicobacter pylori</em> |
| title_full | Relationship Between Human Microbiome and <em>Helicobacter pylori</em> |
| title_fullStr | Relationship Between Human Microbiome and <em>Helicobacter pylori</em> |
| title_full_unstemmed | Relationship Between Human Microbiome and <em>Helicobacter pylori</em> |
| title_short | Relationship Between Human Microbiome and <em>Helicobacter pylori</em> |
| title_sort | relationship between human microbiome and em helicobacter pylori em |
| topic | human microbiota <i>Helicobacter pylori</i> gut gastric genome |
| url | https://www.mdpi.com/2036-7481/16/1/24 |
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