Glucose-6-phosphate dehydrogenase deficiency induced hemolytic anemia and methemoglobinemia: a case report in a 7 -year-old female patient
Abstract Background Patients affected by glucose-6-phosphate dehydrogenase (G6PDH) deficiency are often asymptomatic until an oxidative stress occurs, causing acute hemolytic anemia. The coexistence of hemolytic crisis secondary to G6PDH deficiency and methemoglobinemia is an already known phenomeno...
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2025-08-01
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| Series: | Italian Journal of Pediatrics |
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| Online Access: | https://doi.org/10.1186/s13052-025-02051-2 |
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| author | Adalgisa Fastuca Antonio Vergori Giuseppe Robustelli Chiara Piccolo Maria Ragazzo Maddalena Marinoni Massimo Agosti |
| author_facet | Adalgisa Fastuca Antonio Vergori Giuseppe Robustelli Chiara Piccolo Maria Ragazzo Maddalena Marinoni Massimo Agosti |
| author_sort | Adalgisa Fastuca |
| collection | DOAJ |
| description | Abstract Background Patients affected by glucose-6-phosphate dehydrogenase (G6PDH) deficiency are often asymptomatic until an oxidative stress occurs, causing acute hemolytic anemia. The coexistence of hemolytic crisis secondary to G6PDH deficiency and methemoglobinemia is an already known phenomenon, especially after the ingestion of fava beans. While past literature described this association primarily in adult patients, it remains an unusual finding in pediatric population. Our patient's age, as long as her gender, and a negative family history represent, indeed, the peculiarity of what we described. Case presentation We present the case of a 7-year-old female patient with a clinical history of hyperpyrexia, several episodes of yellowish vomit, hypercromic urine, loose stools, asthenia with jaundice. At home paracetamol and a single dose of ibuprofen were administered. No recent history of fava bean ingestion or relevant events were reported in physiological and pathological anamnesis. Family history was negative for hematological comorbidities. Blood tests performed at the emergency room showed a picture of severe anemia with negative direct and indirect Coombs tests, mild acute renal failure, increased inflammation markers and a methemoglobin level equal to 13.7% on blood gas analysis. The detection of vital parameters showed O2-Sat equal to 75% without signs of respiratory distress. A broad-spectrum antibiotic therapy with ceftriaxone and oxygen-therapy were administered, hospitalization was then arranged. Immune-mediated anemia and lymphoproliferative diseases were excluded. G6PDH dosage was requested, resulting indicative of deficiency. Fecal virus testing revealed a positivity for Norovirus. Transfusions of red cell concentrates (RCC) were performed, and the methemoglobin value gradually decreased with stabilization of the hemoglobin, so that methylene blue therapy was not administrated. The patient’s clinical conditions improved in almost 5 days. Conclusions When G6PDH deficiency and methemoglobinemia coexist, a prompt diagnosis is essential. The administration of methylene blue, therapy of choice for the treatment of methemoglobinemia, in fact, may cause a worsening of hemolytic crises in patients affected by G6PDH deficiency. Considering our patient’s clinical features, not clearly evocative of G6PDH deficiency, this case represented a challenge for both diagnosis and treatment, reminding to always consider G6PDH deficiency in case of hemolytic anemia associated with methemoglobinemia. |
| format | Article |
| id | doaj-art-3ad8ef51129d4aa6a3e7a06bbbd48688 |
| institution | Kabale University |
| issn | 1824-7288 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | BMC |
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| series | Italian Journal of Pediatrics |
| spelling | doaj-art-3ad8ef51129d4aa6a3e7a06bbbd486882025-08-24T11:41:35ZengBMCItalian Journal of Pediatrics1824-72882025-08-015111810.1186/s13052-025-02051-2Glucose-6-phosphate dehydrogenase deficiency induced hemolytic anemia and methemoglobinemia: a case report in a 7 -year-old female patientAdalgisa Fastuca0Antonio Vergori1Giuseppe Robustelli2Chiara Piccolo3Maria Ragazzo4Maddalena Marinoni5Massimo Agosti6University of InsubriaPediatric Unit, Maternal and Child Department, “F. Del Ponte” HospitalPediatric Oncoematology Unit, “F. Del Ponte” HospitalPediatric Oncoematology Unit, “F. Del Ponte” HospitalPediatric Oncoematology Unit, “F. Del Ponte” HospitalPediatric Oncoematology Unit, “F. Del Ponte” HospitalUniversity of InsubriaAbstract Background Patients affected by glucose-6-phosphate dehydrogenase (G6PDH) deficiency are often asymptomatic until an oxidative stress occurs, causing acute hemolytic anemia. The coexistence of hemolytic crisis secondary to G6PDH deficiency and methemoglobinemia is an already known phenomenon, especially after the ingestion of fava beans. While past literature described this association primarily in adult patients, it remains an unusual finding in pediatric population. Our patient's age, as long as her gender, and a negative family history represent, indeed, the peculiarity of what we described. Case presentation We present the case of a 7-year-old female patient with a clinical history of hyperpyrexia, several episodes of yellowish vomit, hypercromic urine, loose stools, asthenia with jaundice. At home paracetamol and a single dose of ibuprofen were administered. No recent history of fava bean ingestion or relevant events were reported in physiological and pathological anamnesis. Family history was negative for hematological comorbidities. Blood tests performed at the emergency room showed a picture of severe anemia with negative direct and indirect Coombs tests, mild acute renal failure, increased inflammation markers and a methemoglobin level equal to 13.7% on blood gas analysis. The detection of vital parameters showed O2-Sat equal to 75% without signs of respiratory distress. A broad-spectrum antibiotic therapy with ceftriaxone and oxygen-therapy were administered, hospitalization was then arranged. Immune-mediated anemia and lymphoproliferative diseases were excluded. G6PDH dosage was requested, resulting indicative of deficiency. Fecal virus testing revealed a positivity for Norovirus. Transfusions of red cell concentrates (RCC) were performed, and the methemoglobin value gradually decreased with stabilization of the hemoglobin, so that methylene blue therapy was not administrated. The patient’s clinical conditions improved in almost 5 days. Conclusions When G6PDH deficiency and methemoglobinemia coexist, a prompt diagnosis is essential. The administration of methylene blue, therapy of choice for the treatment of methemoglobinemia, in fact, may cause a worsening of hemolytic crises in patients affected by G6PDH deficiency. Considering our patient’s clinical features, not clearly evocative of G6PDH deficiency, this case represented a challenge for both diagnosis and treatment, reminding to always consider G6PDH deficiency in case of hemolytic anemia associated with methemoglobinemia.https://doi.org/10.1186/s13052-025-02051-2Case reportHemolytic anemiaGlucose-6-phosphate dehydrogenase (G6PDH) deficiencyMethemoglobinemiaChild |
| spellingShingle | Adalgisa Fastuca Antonio Vergori Giuseppe Robustelli Chiara Piccolo Maria Ragazzo Maddalena Marinoni Massimo Agosti Glucose-6-phosphate dehydrogenase deficiency induced hemolytic anemia and methemoglobinemia: a case report in a 7 -year-old female patient Italian Journal of Pediatrics Case report Hemolytic anemia Glucose-6-phosphate dehydrogenase (G6PDH) deficiency Methemoglobinemia Child |
| title | Glucose-6-phosphate dehydrogenase deficiency induced hemolytic anemia and methemoglobinemia: a case report in a 7 -year-old female patient |
| title_full | Glucose-6-phosphate dehydrogenase deficiency induced hemolytic anemia and methemoglobinemia: a case report in a 7 -year-old female patient |
| title_fullStr | Glucose-6-phosphate dehydrogenase deficiency induced hemolytic anemia and methemoglobinemia: a case report in a 7 -year-old female patient |
| title_full_unstemmed | Glucose-6-phosphate dehydrogenase deficiency induced hemolytic anemia and methemoglobinemia: a case report in a 7 -year-old female patient |
| title_short | Glucose-6-phosphate dehydrogenase deficiency induced hemolytic anemia and methemoglobinemia: a case report in a 7 -year-old female patient |
| title_sort | glucose 6 phosphate dehydrogenase deficiency induced hemolytic anemia and methemoglobinemia a case report in a 7 year old female patient |
| topic | Case report Hemolytic anemia Glucose-6-phosphate dehydrogenase (G6PDH) deficiency Methemoglobinemia Child |
| url | https://doi.org/10.1186/s13052-025-02051-2 |
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