Therapeutic potential of botanical drugs and their metabolites in the treatment of pelvic inflammatory disease
The application of botanical drugs and their metabolites in the treatment of pelvic inflammatory disease (PID) has garnered significant attention. Owing to their broad-spectrum activity, global accessibility, and structural diversity, botanical drugs have emerged as promising candidates for adjuncti...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-04-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2025.1545917/full |
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| author | Han-Zhi Zhong Pei-Jia Yan Qi-Feng Gao Jue Wu Xiao-Li Ji Shao-Bin Wei |
| author_facet | Han-Zhi Zhong Pei-Jia Yan Qi-Feng Gao Jue Wu Xiao-Li Ji Shao-Bin Wei |
| author_sort | Han-Zhi Zhong |
| collection | DOAJ |
| description | The application of botanical drugs and their metabolites in the treatment of pelvic inflammatory disease (PID) has garnered significant attention. Owing to their broad-spectrum activity, global accessibility, and structural diversity, botanical drugs have emerged as promising candidates for adjunctive or alternative therapies. This review systematically summarizes botanical drugs and their metabolites, focusing on their antimicrobial potential against endogenous and exogenous pathogens associated with PID. Specifically, it addresses various underlying antibacterial mechanisms, including interference with bacterial cell membranes and cell walls, inhibition of pathogen-specific efflux pumps, modulation of pathogen-related gene expression, and synergistic effects when combined with conventional antibiotics. This review highlights the therapeutic promise of botanical drugs and their metabolites, emphasizing critical findings regarding their inhibitory effects on PID-associated pathogens. Such insights provide valuable guidance for future therapeutic strategies and may support ongoing antibiotic discovery and development. |
| format | Article |
| id | doaj-art-3ad490a2b2cb485e9bc4db934c73e913 |
| institution | OA Journals |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-3ad490a2b2cb485e9bc4db934c73e9132025-08-20T02:15:40ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-04-011610.3389/fphar.2025.15459171545917Therapeutic potential of botanical drugs and their metabolites in the treatment of pelvic inflammatory diseaseHan-Zhi Zhong0Pei-Jia Yan1Qi-Feng Gao2Jue Wu3Xiao-Li Ji4Shao-Bin Wei5School of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaSchool of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaSchool of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaSchool of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaDepartment of Gynecology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaDepartment of Gynecology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaThe application of botanical drugs and their metabolites in the treatment of pelvic inflammatory disease (PID) has garnered significant attention. Owing to their broad-spectrum activity, global accessibility, and structural diversity, botanical drugs have emerged as promising candidates for adjunctive or alternative therapies. This review systematically summarizes botanical drugs and their metabolites, focusing on their antimicrobial potential against endogenous and exogenous pathogens associated with PID. Specifically, it addresses various underlying antibacterial mechanisms, including interference with bacterial cell membranes and cell walls, inhibition of pathogen-specific efflux pumps, modulation of pathogen-related gene expression, and synergistic effects when combined with conventional antibiotics. This review highlights the therapeutic promise of botanical drugs and their metabolites, emphasizing critical findings regarding their inhibitory effects on PID-associated pathogens. Such insights provide valuable guidance for future therapeutic strategies and may support ongoing antibiotic discovery and development.https://www.frontiersin.org/articles/10.3389/fphar.2025.1545917/fullantimicrobialChlamydia trachomatismechanismNeisseria gonorrhoeaepelvic inflammatory disease |
| spellingShingle | Han-Zhi Zhong Pei-Jia Yan Qi-Feng Gao Jue Wu Xiao-Li Ji Shao-Bin Wei Therapeutic potential of botanical drugs and their metabolites in the treatment of pelvic inflammatory disease Frontiers in Pharmacology antimicrobial Chlamydia trachomatis mechanism Neisseria gonorrhoeae pelvic inflammatory disease |
| title | Therapeutic potential of botanical drugs and their metabolites in the treatment of pelvic inflammatory disease |
| title_full | Therapeutic potential of botanical drugs and their metabolites in the treatment of pelvic inflammatory disease |
| title_fullStr | Therapeutic potential of botanical drugs and their metabolites in the treatment of pelvic inflammatory disease |
| title_full_unstemmed | Therapeutic potential of botanical drugs and their metabolites in the treatment of pelvic inflammatory disease |
| title_short | Therapeutic potential of botanical drugs and their metabolites in the treatment of pelvic inflammatory disease |
| title_sort | therapeutic potential of botanical drugs and their metabolites in the treatment of pelvic inflammatory disease |
| topic | antimicrobial Chlamydia trachomatis mechanism Neisseria gonorrhoeae pelvic inflammatory disease |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2025.1545917/full |
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