HE-4 in the Diagnosis of Carcinoma of Ovary Presented as Unknown primary Carcinoma: A Case Report
Ovarian cancer is the second most common gynecologic malignancy in the United States, with high mortality due to delayed diagnosis. Serum CA-125 is widely used for screening and monitoring but lacks sensitivity and specificity in some cases. We present a 67-year-old female diagnosed with advanced-st...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2025-06-01
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| Series: | Journal of Investigative Medicine High Impact Case Reports |
| Online Access: | https://doi.org/10.1177/23247096251344701 |
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| author | Shengmin Huang MD Muhammad Tahir MD Gardith Joseph MD Richrd Wu MD Jaron Tepper MD Jen C. Wang MD |
| author_facet | Shengmin Huang MD Muhammad Tahir MD Gardith Joseph MD Richrd Wu MD Jaron Tepper MD Jen C. Wang MD |
| author_sort | Shengmin Huang MD |
| collection | DOAJ |
| description | Ovarian cancer is the second most common gynecologic malignancy in the United States, with high mortality due to delayed diagnosis. Serum CA-125 is widely used for screening and monitoring but lacks sensitivity and specificity in some cases. We present a 67-year-old female diagnosed with advanced-stage ovarian cancer despite normal CA-125 levels, with elevated HE4 (human epididymis protein 4), underscoring its diagnostic value. This case highlights the importance of integrating HE4 with CA-125 in ovarian cancer evaluation and emphasizes a multimodal approach to enhance early detection and outcomes. |
| format | Article |
| id | doaj-art-3acb713b747046d089ca3bafee306f13 |
| institution | OA Journals |
| issn | 2324-7096 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of Investigative Medicine High Impact Case Reports |
| spelling | doaj-art-3acb713b747046d089ca3bafee306f132025-08-20T02:36:58ZengSAGE PublishingJournal of Investigative Medicine High Impact Case Reports2324-70962025-06-011310.1177/23247096251344701HE-4 in the Diagnosis of Carcinoma of Ovary Presented as Unknown primary Carcinoma: A Case ReportShengmin Huang MD0Muhammad Tahir MD1Gardith Joseph MD2Richrd Wu MD3Jaron Tepper MD4Jen C. Wang MD5Brookdale University Hospital Medical Center, Brooklyn, NY, USABrookdale University Hospital Medical Center, Brooklyn, NY, USABrookdale University Hospital Medical Center, Brooklyn, NY, USABrookdale University Hospital Medical Center, Brooklyn, NY, USABrookdale University Hospital Medical Center, Brooklyn, NY, USABrookdale University Hospital Medical Center, Brooklyn, NY, USAOvarian cancer is the second most common gynecologic malignancy in the United States, with high mortality due to delayed diagnosis. Serum CA-125 is widely used for screening and monitoring but lacks sensitivity and specificity in some cases. We present a 67-year-old female diagnosed with advanced-stage ovarian cancer despite normal CA-125 levels, with elevated HE4 (human epididymis protein 4), underscoring its diagnostic value. This case highlights the importance of integrating HE4 with CA-125 in ovarian cancer evaluation and emphasizes a multimodal approach to enhance early detection and outcomes.https://doi.org/10.1177/23247096251344701 |
| spellingShingle | Shengmin Huang MD Muhammad Tahir MD Gardith Joseph MD Richrd Wu MD Jaron Tepper MD Jen C. Wang MD HE-4 in the Diagnosis of Carcinoma of Ovary Presented as Unknown primary Carcinoma: A Case Report Journal of Investigative Medicine High Impact Case Reports |
| title | HE-4 in the Diagnosis of Carcinoma of Ovary Presented as Unknown primary Carcinoma: A Case Report |
| title_full | HE-4 in the Diagnosis of Carcinoma of Ovary Presented as Unknown primary Carcinoma: A Case Report |
| title_fullStr | HE-4 in the Diagnosis of Carcinoma of Ovary Presented as Unknown primary Carcinoma: A Case Report |
| title_full_unstemmed | HE-4 in the Diagnosis of Carcinoma of Ovary Presented as Unknown primary Carcinoma: A Case Report |
| title_short | HE-4 in the Diagnosis of Carcinoma of Ovary Presented as Unknown primary Carcinoma: A Case Report |
| title_sort | he 4 in the diagnosis of carcinoma of ovary presented as unknown primary carcinoma a case report |
| url | https://doi.org/10.1177/23247096251344701 |
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