NLRP3: A Novel Mediator in Cardiovascular Disease
Cardiovascular disease is a major cause of death worldwide. Inflammasome infiltration has been identified to play a central role in the pathological progression of certain cardiovascular diseases, such as vascular damage spanning atherosclerosis, aneurysm, or arteritis; ischemic heart disease; and o...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2018-01-01
|
| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2018/5702103 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849304715155734528 |
|---|---|
| author | Wenyi Zhou Chunyuan Chen Zhiheng Chen Lin Liu Jie Jiang Zhixiang Wu Mingyi Zhao Yanfang Chen |
| author_facet | Wenyi Zhou Chunyuan Chen Zhiheng Chen Lin Liu Jie Jiang Zhixiang Wu Mingyi Zhao Yanfang Chen |
| author_sort | Wenyi Zhou |
| collection | DOAJ |
| description | Cardiovascular disease is a major cause of death worldwide. Inflammasome infiltration has been identified to play a central role in the pathological progression of certain cardiovascular diseases, such as vascular damage spanning atherosclerosis, aneurysm, or arteritis; ischemic heart disease; and other nonischemic heart diseases including diabetic cardiomyopathy, chronic heart failure, and hypertension- or virus-induced cardiac dysfunction. The NLRP3 inflammasome, a key participant in the innate immune response, requires both priming and activation signals for the initiation of inflammation. Piling evidence has revealed that the NLRP3 inflammasome could exert an inflammatory effect by inducing the secretion of proinflammatory cytokines (i.e., IL-1β, IL-18) or could cause pyroptosis, a novel programmed cell death process, in a caspase-1-dependent manner. The importance of the NLRP3 inflammasome in cardiac disease has been broadly investigated. In this review, we present the current knowledge regarding the function of NLRP in vascular disease, ischemic heart disease, and nonischemic heart disease and discuss the potential therapeutic options targeting the NLRP3 inflammasome. |
| format | Article |
| id | doaj-art-3ac0ee80669f4acd8d5b19cc34d1a851 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-3ac0ee80669f4acd8d5b19cc34d1a8512025-08-20T03:55:40ZengWileyJournal of Immunology Research2314-88612314-71562018-01-01201810.1155/2018/57021035702103NLRP3: A Novel Mediator in Cardiovascular DiseaseWenyi Zhou0Chunyuan Chen1Zhiheng Chen2Lin Liu3Jie Jiang4Zhixiang Wu5Mingyi Zhao6Yanfang Chen7Cardiovascular Department, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou Institute of Cardiovascular Disease, Guangzhou 510000, ChinaDepartment of Pediatrics, The Third Xiangya Hospital, Central South University, Changsha 410013, ChinaDepartment of Pediatrics, The Third Xiangya Hospital, Central South University, Changsha 410013, ChinaDepartment of Pediatrics, The Third Xiangya Hospital, Central South University, Changsha 410013, ChinaDepartment of Pediatrics, The Third Xiangya Hospital, Central South University, Changsha 410013, ChinaDepartment of Pediatrics, The Third Xiangya Hospital, Central South University, Changsha 410013, ChinaDepartment of Pediatrics, The Third Xiangya Hospital, Central South University, Changsha 410013, ChinaCardiovascular Department, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou Institute of Cardiovascular Disease, Guangzhou 510000, ChinaCardiovascular disease is a major cause of death worldwide. Inflammasome infiltration has been identified to play a central role in the pathological progression of certain cardiovascular diseases, such as vascular damage spanning atherosclerosis, aneurysm, or arteritis; ischemic heart disease; and other nonischemic heart diseases including diabetic cardiomyopathy, chronic heart failure, and hypertension- or virus-induced cardiac dysfunction. The NLRP3 inflammasome, a key participant in the innate immune response, requires both priming and activation signals for the initiation of inflammation. Piling evidence has revealed that the NLRP3 inflammasome could exert an inflammatory effect by inducing the secretion of proinflammatory cytokines (i.e., IL-1β, IL-18) or could cause pyroptosis, a novel programmed cell death process, in a caspase-1-dependent manner. The importance of the NLRP3 inflammasome in cardiac disease has been broadly investigated. In this review, we present the current knowledge regarding the function of NLRP in vascular disease, ischemic heart disease, and nonischemic heart disease and discuss the potential therapeutic options targeting the NLRP3 inflammasome.http://dx.doi.org/10.1155/2018/5702103 |
| spellingShingle | Wenyi Zhou Chunyuan Chen Zhiheng Chen Lin Liu Jie Jiang Zhixiang Wu Mingyi Zhao Yanfang Chen NLRP3: A Novel Mediator in Cardiovascular Disease Journal of Immunology Research |
| title | NLRP3: A Novel Mediator in Cardiovascular Disease |
| title_full | NLRP3: A Novel Mediator in Cardiovascular Disease |
| title_fullStr | NLRP3: A Novel Mediator in Cardiovascular Disease |
| title_full_unstemmed | NLRP3: A Novel Mediator in Cardiovascular Disease |
| title_short | NLRP3: A Novel Mediator in Cardiovascular Disease |
| title_sort | nlrp3 a novel mediator in cardiovascular disease |
| url | http://dx.doi.org/10.1155/2018/5702103 |
| work_keys_str_mv | AT wenyizhou nlrp3anovelmediatorincardiovasculardisease AT chunyuanchen nlrp3anovelmediatorincardiovasculardisease AT zhihengchen nlrp3anovelmediatorincardiovasculardisease AT linliu nlrp3anovelmediatorincardiovasculardisease AT jiejiang nlrp3anovelmediatorincardiovasculardisease AT zhixiangwu nlrp3anovelmediatorincardiovasculardisease AT mingyizhao nlrp3anovelmediatorincardiovasculardisease AT yanfangchen nlrp3anovelmediatorincardiovasculardisease |