Mixed selling of different poultry species facilitates emergence of public-health-threating avian influenza viruses
Live poultry markets (LPMs) are regarded as hubs for avian influenza virus (AIV) transmission in poultry and are a major risk factor in human AIV infections. We performed an AIV surveillance study at a wholesale LPM, where different poultry species were sold in separate stalls, and nine retail LPMs,...
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Taylor & Francis Group
2023-12-01
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| Series: | Emerging Microbes and Infections |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/22221751.2023.2214255 |
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| author | Zhen Wang Hongkui Li Yuhan Li Zhuanli Wu Hui Ai Ming Zhang Libin Rong Michael L. Blinov Qi Tong Litao Liu Honglei Sun Juan Pu Wenhai Feng Jinhua Liu Yipeng Sun |
| author_facet | Zhen Wang Hongkui Li Yuhan Li Zhuanli Wu Hui Ai Ming Zhang Libin Rong Michael L. Blinov Qi Tong Litao Liu Honglei Sun Juan Pu Wenhai Feng Jinhua Liu Yipeng Sun |
| author_sort | Zhen Wang |
| collection | DOAJ |
| description | Live poultry markets (LPMs) are regarded as hubs for avian influenza virus (AIV) transmission in poultry and are a major risk factor in human AIV infections. We performed an AIV surveillance study at a wholesale LPM, where different poultry species were sold in separate stalls, and nine retail LPMs, which received poultry from the wholesale LPM but where different poultry species were sold in one stall, in Guangdong province from 2017 to 2019. A higher AIV isolation rate was observed at the retail LPMs than the wholesale LPM. H9N2 was the dominant AIV subtype and was mainly present in chickens and quails. The genetic diversity of H9N2 viruses was greater at the retail LPMs, where a complex system of two-way transmission between different poultry species had formed. The isolated H9N2 viruses could be classed into four genotypes: G57 and the three novel genotypes, NG164, NG165, and NG166. The H9N2 AIVs isolated from chickens and quails at the wholesale LPM only belonged to the G57 and NG164 genotypes, respectively. However, the G57, NG164, and NG165 genotypes were identified in both chickens and quails at the retail LPMs. We found that the replication and transmission of the NG165 genotype were more adaptive to both poultry and mammalian models than those of its precursor genotype, NG164. Our findings revealed that mixed poultry selling at retail LPMs has increased the genetic diversity of AIVs, which might facilitate the emergence of novel viruses that threaten public health. |
| format | Article |
| id | doaj-art-3abf9646facf4cf1bb94d2df32fcbdec |
| institution | Kabale University |
| issn | 2222-1751 |
| language | English |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Emerging Microbes and Infections |
| spelling | doaj-art-3abf9646facf4cf1bb94d2df32fcbdec2025-08-20T03:52:56ZengTaylor & Francis GroupEmerging Microbes and Infections2222-17512023-12-0112110.1080/22221751.2023.2214255Mixed selling of different poultry species facilitates emergence of public-health-threating avian influenza virusesZhen Wang0Hongkui Li1Yuhan Li2Zhuanli Wu3Hui Ai4Ming Zhang5Libin Rong6Michael L. Blinov7Qi Tong8Litao Liu9Honglei Sun10Juan Pu11Wenhai Feng12Jinhua Liu13Yipeng Sun14National Key Laboratory of Veterinary Public Health Security, Key Laboratory for Prevention and Control of Avian Influenza and Other Major Poultry Diseases and Key Laboratory of Animal Epidemiology of Ministry of Agriculture and Rural Affairs, College of Veterinary Medicine, China Agricultural University, Beijing, People’s Republic of ChinaLiaoning Agricultural Development Service Center, Shenyang, People’s Republic of ChinaNational Key Laboratory of Veterinary Public Health Security, Key Laboratory for Prevention and Control of Avian Influenza and Other Major Poultry Diseases and Key Laboratory of Animal Epidemiology of Ministry of Agriculture and Rural Affairs, College of Veterinary Medicine, China Agricultural University, Beijing, People’s Republic of ChinaNational Key Laboratory of Veterinary Public Health Security, Key Laboratory for Prevention and Control of Avian Influenza and Other Major Poultry Diseases and Key Laboratory of Animal Epidemiology of Ministry of Agriculture and Rural Affairs, College of Veterinary Medicine, China Agricultural University, Beijing, People’s Republic of ChinaNational Key Laboratory of Veterinary Public Health Security, Key Laboratory for Prevention and Control of Avian Influenza and Other Major Poultry Diseases and Key Laboratory of Animal Epidemiology of Ministry of Agriculture and Rural Affairs, College of Veterinary Medicine, China Agricultural University, Beijing, People’s Republic of ChinaDepartment of Epidemiology and Biostatistics, University of Georgia, Athens, GA, USADepartment of Mathematics, University of Florida, Gainesville, FL, USACenter for Cell Analysis and Modeling, University of Connecticut School of Medicine, Farmington, CT, USANational Key Laboratory of Veterinary Public Health Security, Key Laboratory for Prevention and Control of Avian Influenza and Other Major Poultry Diseases and Key Laboratory of Animal Epidemiology of Ministry of Agriculture and Rural Affairs, College of Veterinary Medicine, China Agricultural University, Beijing, People’s Republic of ChinaNational Key Laboratory of Veterinary Public Health Security, Key Laboratory for Prevention and Control of Avian Influenza and Other Major Poultry Diseases and Key Laboratory of Animal Epidemiology of Ministry of Agriculture and Rural Affairs, College of Veterinary Medicine, China Agricultural University, Beijing, People’s Republic of ChinaNational Key Laboratory of Veterinary Public Health Security, Key Laboratory for Prevention and Control of Avian Influenza and Other Major Poultry Diseases and Key Laboratory of Animal Epidemiology of Ministry of Agriculture and Rural Affairs, College of Veterinary Medicine, China Agricultural University, Beijing, People’s Republic of ChinaNational Key Laboratory of Veterinary Public Health Security, Key Laboratory for Prevention and Control of Avian Influenza and Other Major Poultry Diseases and Key Laboratory of Animal Epidemiology of Ministry of Agriculture and Rural Affairs, College of Veterinary Medicine, China Agricultural University, Beijing, People’s Republic of ChinaState Key Laboratories of Agrobiotechnology, and Department of Microbiology and Immunology, College of Biological Science, China Agricultural University, Beijing, People’s Republic of ChinaNational Key Laboratory of Veterinary Public Health Security, Key Laboratory for Prevention and Control of Avian Influenza and Other Major Poultry Diseases and Key Laboratory of Animal Epidemiology of Ministry of Agriculture and Rural Affairs, College of Veterinary Medicine, China Agricultural University, Beijing, People’s Republic of ChinaNational Key Laboratory of Veterinary Public Health Security, Key Laboratory for Prevention and Control of Avian Influenza and Other Major Poultry Diseases and Key Laboratory of Animal Epidemiology of Ministry of Agriculture and Rural Affairs, College of Veterinary Medicine, China Agricultural University, Beijing, People’s Republic of ChinaLive poultry markets (LPMs) are regarded as hubs for avian influenza virus (AIV) transmission in poultry and are a major risk factor in human AIV infections. We performed an AIV surveillance study at a wholesale LPM, where different poultry species were sold in separate stalls, and nine retail LPMs, which received poultry from the wholesale LPM but where different poultry species were sold in one stall, in Guangdong province from 2017 to 2019. A higher AIV isolation rate was observed at the retail LPMs than the wholesale LPM. H9N2 was the dominant AIV subtype and was mainly present in chickens and quails. The genetic diversity of H9N2 viruses was greater at the retail LPMs, where a complex system of two-way transmission between different poultry species had formed. The isolated H9N2 viruses could be classed into four genotypes: G57 and the three novel genotypes, NG164, NG165, and NG166. The H9N2 AIVs isolated from chickens and quails at the wholesale LPM only belonged to the G57 and NG164 genotypes, respectively. However, the G57, NG164, and NG165 genotypes were identified in both chickens and quails at the retail LPMs. We found that the replication and transmission of the NG165 genotype were more adaptive to both poultry and mammalian models than those of its precursor genotype, NG164. Our findings revealed that mixed poultry selling at retail LPMs has increased the genetic diversity of AIVs, which might facilitate the emergence of novel viruses that threaten public health.https://www.tandfonline.com/doi/10.1080/22221751.2023.2214255Avian influenza viruslive poultry marketsmixed sellingreassortmentpublic health risk |
| spellingShingle | Zhen Wang Hongkui Li Yuhan Li Zhuanli Wu Hui Ai Ming Zhang Libin Rong Michael L. Blinov Qi Tong Litao Liu Honglei Sun Juan Pu Wenhai Feng Jinhua Liu Yipeng Sun Mixed selling of different poultry species facilitates emergence of public-health-threating avian influenza viruses Emerging Microbes and Infections Avian influenza virus live poultry markets mixed selling reassortment public health risk |
| title | Mixed selling of different poultry species facilitates emergence of public-health-threating avian influenza viruses |
| title_full | Mixed selling of different poultry species facilitates emergence of public-health-threating avian influenza viruses |
| title_fullStr | Mixed selling of different poultry species facilitates emergence of public-health-threating avian influenza viruses |
| title_full_unstemmed | Mixed selling of different poultry species facilitates emergence of public-health-threating avian influenza viruses |
| title_short | Mixed selling of different poultry species facilitates emergence of public-health-threating avian influenza viruses |
| title_sort | mixed selling of different poultry species facilitates emergence of public health threating avian influenza viruses |
| topic | Avian influenza virus live poultry markets mixed selling reassortment public health risk |
| url | https://www.tandfonline.com/doi/10.1080/22221751.2023.2214255 |
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