Helicobacter pylori in peptic ulcer disease: pathogenesis, gastric microbiome, and innovative therapies
Abstract The gastrointestinal (GI) system is fundamental to human health, managing digestion, nutrient absorption, and waste elimination. Among the pathogens that disrupt this system, Helicobacter pylori (HP) stands out as a major contributor to GI disorders, including gastritis, peptic ulcers, and...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2025-08-01
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| Series: | Bulletin of the National Research Centre |
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| Online Access: | https://doi.org/10.1186/s42269-025-01346-y |
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| author | Sourav Pal Junaid Ahamed Laskar Biprojit Bhowmick Khokan Bera |
| author_facet | Sourav Pal Junaid Ahamed Laskar Biprojit Bhowmick Khokan Bera |
| author_sort | Sourav Pal |
| collection | DOAJ |
| description | Abstract The gastrointestinal (GI) system is fundamental to human health, managing digestion, nutrient absorption, and waste elimination. Among the pathogens that disrupt this system, Helicobacter pylori (HP) stands out as a major contributor to GI disorders, including gastritis, peptic ulcers, and gastric cancer. Given the well-documented and escalating crisis of antibiotic resistance, which undermines the efficacy of conventional antibiotic therapies, there is a pressing need to explore alternative treatment approaches. This review examines the colonization and the pathophysiology of HP infection, as well as the molecular mechanisms underlying its associated diseases. Furthermore, this study investigates novel treatments, emphasizing herbal alternatives like curcumin and green tea, which are well-known for their anti-inflammatory and antioxidant abilities, as well as marine-based remedies like fucoidan and chitosan, which are abundant in bioactive components with antimicrobial and anti-cancer qualities. Their diverse bioactive constituents offer broad-spectrum health benefits, and the absence of observed cross-resistance enhances their therapeutic appeal. This review seeks to provide a holistic approach to managing HP-related disorders by including insights into the digestive system and emerging strategies for treatment. |
| format | Article |
| id | doaj-art-3abf4d4326ff4eddb8703c1fdccbc8e0 |
| institution | Kabale University |
| issn | 2522-8307 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Bulletin of the National Research Centre |
| spelling | doaj-art-3abf4d4326ff4eddb8703c1fdccbc8e02025-08-20T03:42:19ZengSpringerOpenBulletin of the National Research Centre2522-83072025-08-0149111910.1186/s42269-025-01346-yHelicobacter pylori in peptic ulcer disease: pathogenesis, gastric microbiome, and innovative therapiesSourav Pal0Junaid Ahamed Laskar1Biprojit Bhowmick2Khokan Bera3Department of Pharmacology, Seacom Pharmacy CollegeSeacom Pharmacy CollegeDepartment of Pharmacology, Seacom Pharmacy CollegeDepartment of Pharmacy, Seacom Pharmacy CollegeAbstract The gastrointestinal (GI) system is fundamental to human health, managing digestion, nutrient absorption, and waste elimination. Among the pathogens that disrupt this system, Helicobacter pylori (HP) stands out as a major contributor to GI disorders, including gastritis, peptic ulcers, and gastric cancer. Given the well-documented and escalating crisis of antibiotic resistance, which undermines the efficacy of conventional antibiotic therapies, there is a pressing need to explore alternative treatment approaches. This review examines the colonization and the pathophysiology of HP infection, as well as the molecular mechanisms underlying its associated diseases. Furthermore, this study investigates novel treatments, emphasizing herbal alternatives like curcumin and green tea, which are well-known for their anti-inflammatory and antioxidant abilities, as well as marine-based remedies like fucoidan and chitosan, which are abundant in bioactive components with antimicrobial and anti-cancer qualities. Their diverse bioactive constituents offer broad-spectrum health benefits, and the absence of observed cross-resistance enhances their therapeutic appeal. This review seeks to provide a holistic approach to managing HP-related disorders by including insights into the digestive system and emerging strategies for treatment.https://doi.org/10.1186/s42269-025-01346-yHelicobacter pyloriCytotoxinGastric disorderCarcinogenesisEmerging therapies |
| spellingShingle | Sourav Pal Junaid Ahamed Laskar Biprojit Bhowmick Khokan Bera Helicobacter pylori in peptic ulcer disease: pathogenesis, gastric microbiome, and innovative therapies Bulletin of the National Research Centre Helicobacter pylori Cytotoxin Gastric disorder Carcinogenesis Emerging therapies |
| title | Helicobacter pylori in peptic ulcer disease: pathogenesis, gastric microbiome, and innovative therapies |
| title_full | Helicobacter pylori in peptic ulcer disease: pathogenesis, gastric microbiome, and innovative therapies |
| title_fullStr | Helicobacter pylori in peptic ulcer disease: pathogenesis, gastric microbiome, and innovative therapies |
| title_full_unstemmed | Helicobacter pylori in peptic ulcer disease: pathogenesis, gastric microbiome, and innovative therapies |
| title_short | Helicobacter pylori in peptic ulcer disease: pathogenesis, gastric microbiome, and innovative therapies |
| title_sort | helicobacter pylori in peptic ulcer disease pathogenesis gastric microbiome and innovative therapies |
| topic | Helicobacter pylori Cytotoxin Gastric disorder Carcinogenesis Emerging therapies |
| url | https://doi.org/10.1186/s42269-025-01346-y |
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