Genetic transcriptional regulation profiling of cartilage reveals pathogenesis of osteoarthritisResearch in context

Genetic transcriptional regulation profiling of cartilage reveals pathogenesis of osteoarthritisResearch in context

Summary: Background: Genome-wide association studies (GWAS) have identified more than one hundred risk loci for osteoarthritis (OA). Identifying the effector genes and deciphering the underlying regulatory mechanisms are of great importance but remains challenging due to limited availability of OA-...

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Main Authors: Wen Tian, Shan-Shan Dong, Feng Jiang, Jun-Qi Zhang, Chen Wang, Chang-Yi He, Shou-Ye Hu, Ruo-Han Hao, Hui-Miao Song, Hui-Wu Gao, Ke An, Dong-Li Zhu, Zhi Yang, Yan Guo, Tie-Lin Yang
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:EBioMedicine
Subjects:
Cartilage
Osteoarthritis
eQTL
Fine-mapping
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396425002658
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