HER2-low prevalence among Hispanic/Latino women with breast cancer: A systematic review and meta-analysis.
<h4>Purpose</h4>HER2-low has garnered significant attention for the treatment of HER2-negative breast cancer. We aimed to determine the prevalence of HER2-low expression in Hispanic/Latino women with breast cancer (BC).<h4>Methods</h4>We searched in Embase, LILACS, and Medlin...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2024-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0315287 |
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| author | Daniel Felipe Mendivelso-González Daniel Clavijo Cabezas Luisa Montoya Merideidy Plazas Vargas Patricia López-Correa Eugenia Colón Rafael Parra-Medina |
| author_facet | Daniel Felipe Mendivelso-González Daniel Clavijo Cabezas Luisa Montoya Merideidy Plazas Vargas Patricia López-Correa Eugenia Colón Rafael Parra-Medina |
| author_sort | Daniel Felipe Mendivelso-González |
| collection | DOAJ |
| description | <h4>Purpose</h4>HER2-low has garnered significant attention for the treatment of HER2-negative breast cancer. We aimed to determine the prevalence of HER2-low expression in Hispanic/Latino women with breast cancer (BC).<h4>Methods</h4>We searched in Embase, LILACS, and Medline databases for articles reporting the expression of HER2 immunohistochemistry with scores reported as 0, 1+, 2+, or 3+, with equivocal cases (2+) confirmed through in situ hybridization (ISH).<h4>Results</h4>A total of 12 articles were finally included, comprising 73,467 individuals. The prevalence of HER2-zero, HER2-low and HER2 positive cases among all BC (0, 1+, 2+/ISH-, 2+/ISH+ and 3+), was 45.0%, 32.0%, and 23.0%, respectively. The prevalence of HER2-zero and HER2-low expression among negative cases (0, 1+ and 2+/ISH-), was 53.0% and 47.0%, respectively.<h4>Conclusion</h4>There is an important percentage of Hispanic/Latino individuals who would benefit from HER2-targeted therapies, even in HER2 negative cases. Additional research on the prevalence of HER2-low tumors across a wider range of Latin American countries is required to better understand the molecular epidemiology of this biomarker within the Hispanic/Latino population. |
| format | Article |
| id | doaj-art-3ab3de9ae05445d1b01f764da9735d1d |
| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-3ab3de9ae05445d1b01f764da9735d1d2025-01-01T05:31:06ZengPublic Library of Science (PLoS)PLoS ONE1932-62032024-01-011912e031528710.1371/journal.pone.0315287HER2-low prevalence among Hispanic/Latino women with breast cancer: A systematic review and meta-analysis.Daniel Felipe Mendivelso-GonzálezDaniel Clavijo CabezasLuisa MontoyaMerideidy Plazas VargasPatricia López-CorreaEugenia ColónRafael Parra-Medina<h4>Purpose</h4>HER2-low has garnered significant attention for the treatment of HER2-negative breast cancer. We aimed to determine the prevalence of HER2-low expression in Hispanic/Latino women with breast cancer (BC).<h4>Methods</h4>We searched in Embase, LILACS, and Medline databases for articles reporting the expression of HER2 immunohistochemistry with scores reported as 0, 1+, 2+, or 3+, with equivocal cases (2+) confirmed through in situ hybridization (ISH).<h4>Results</h4>A total of 12 articles were finally included, comprising 73,467 individuals. The prevalence of HER2-zero, HER2-low and HER2 positive cases among all BC (0, 1+, 2+/ISH-, 2+/ISH+ and 3+), was 45.0%, 32.0%, and 23.0%, respectively. The prevalence of HER2-zero and HER2-low expression among negative cases (0, 1+ and 2+/ISH-), was 53.0% and 47.0%, respectively.<h4>Conclusion</h4>There is an important percentage of Hispanic/Latino individuals who would benefit from HER2-targeted therapies, even in HER2 negative cases. Additional research on the prevalence of HER2-low tumors across a wider range of Latin American countries is required to better understand the molecular epidemiology of this biomarker within the Hispanic/Latino population.https://doi.org/10.1371/journal.pone.0315287 |
| spellingShingle | Daniel Felipe Mendivelso-González Daniel Clavijo Cabezas Luisa Montoya Merideidy Plazas Vargas Patricia López-Correa Eugenia Colón Rafael Parra-Medina HER2-low prevalence among Hispanic/Latino women with breast cancer: A systematic review and meta-analysis. PLoS ONE |
| title | HER2-low prevalence among Hispanic/Latino women with breast cancer: A systematic review and meta-analysis. |
| title_full | HER2-low prevalence among Hispanic/Latino women with breast cancer: A systematic review and meta-analysis. |
| title_fullStr | HER2-low prevalence among Hispanic/Latino women with breast cancer: A systematic review and meta-analysis. |
| title_full_unstemmed | HER2-low prevalence among Hispanic/Latino women with breast cancer: A systematic review and meta-analysis. |
| title_short | HER2-low prevalence among Hispanic/Latino women with breast cancer: A systematic review and meta-analysis. |
| title_sort | her2 low prevalence among hispanic latino women with breast cancer a systematic review and meta analysis |
| url | https://doi.org/10.1371/journal.pone.0315287 |
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