Frailty assessment in adults undergoing allogeneic hematopoietic cell transplantation: insights from a multicenter GETH-TC study to optimize outcomes and care
IntroductionThis multicenter prospective study sponsored by the Grupo Español de Transplante Hematopoyético y Terapia Celular (GETH-TC) explores the use of frailty assessments in allo-HCT candidates.MethodsFrailty was measured using the HCT Frailty Scale at first consultation and HCT admission in 4...
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Frontiers Media S.A.
2025-01-01
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| author | María Queralt Salas María Teresa Solano Mónica Baile González Marina Acera Gómez Laura Fox María del Mar Pérez Artigas Ana Santamaría María del Carmen Quintela González Andrés Sánchez Salinas Joaquina M. Salmerón Camacho Verónica Illana Álvaro Zahra Abdallahi-Lefdil Javier Cornago Navascues Laura Pardo Sara Fernández-Luis Leddy Patricia Vega Suárez Sara Villar Patricia Beorlegui-Murillo Albert Esquirol Isabel Izquierdo García Sonia Rodríguez González Alberto Mussetti Esperanza Lavilla Javier Lopez-Marín Silvia Filaferro Ángel Cedillo Leyre Bento Leyre Bento Anna Sureda Anna Sureda |
| author_facet | María Queralt Salas María Teresa Solano Mónica Baile González Marina Acera Gómez Laura Fox María del Mar Pérez Artigas Ana Santamaría María del Carmen Quintela González Andrés Sánchez Salinas Joaquina M. Salmerón Camacho Verónica Illana Álvaro Zahra Abdallahi-Lefdil Javier Cornago Navascues Laura Pardo Sara Fernández-Luis Leddy Patricia Vega Suárez Sara Villar Patricia Beorlegui-Murillo Albert Esquirol Isabel Izquierdo García Sonia Rodríguez González Alberto Mussetti Esperanza Lavilla Javier Lopez-Marín Silvia Filaferro Ángel Cedillo Leyre Bento Leyre Bento Anna Sureda Anna Sureda |
| author_sort | María Queralt Salas |
| collection | DOAJ |
| description | IntroductionThis multicenter prospective study sponsored by the Grupo Español de Transplante Hematopoyético y Terapia Celular (GETH-TC) explores the use of frailty assessments in allo-HCT candidates.MethodsFrailty was measured using the HCT Frailty Scale at first consultation and HCT admission in 404 adults from 15 HCT programs in Spain. Based on the results, patients were classified into fit, pre-frail and frail categories. Allo-HCT outcomes were analyzed according to the results obtained from the HCT Frailty Scale. Data was collected prospectively and all patients signed informed consent.ResultsAt first consultation, 102 (26.2%) patients were classified as fit, 248 (61.4%) as pre-frail, and 50 (12.4%) as frail. During the study, 62 (15.2%) patients participated in a pre-habilitation program. Among non-pre-habilitated patients (n=342), the proportion of fit patients decreased from 26.6% to 16.7%, while frail patients increased from 12.7% to 19.9%. In contrast, pre-habilitated patients (n=62) showed improvements, with fit patients increasing from 24.2% to 46.8%, and frail patients decreasing from 9.7% to 3.2%. Multivariate analysis confirmed lower OS (HR 2.52, P=0.002) and higher NRM (HR 2.69, P=0.013) in frail patients at HCT admission compared to fit ones, with a trend towards lower OS in pre-frail patients (HR 1.54, P=0.097).ConclusionThis study highlights the feasibility of incorporating the HCT Frailty Scale into clinical practice, confirms its negative impact of frailty on transplant outcomes, and suggests that frailty is dynamic and potentially reversible through pre-transplant interventions. |
| format | Article |
| id | doaj-art-3ab3bf1544734c1abbc27e46e9f62071 |
| institution | Kabale University |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-3ab3bf1544734c1abbc27e46e9f620712025-01-07T06:47:03ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-01-011510.3389/fimmu.2024.15121541512154Frailty assessment in adults undergoing allogeneic hematopoietic cell transplantation: insights from a multicenter GETH-TC study to optimize outcomes and careMaría Queralt Salas0María Teresa Solano1Mónica Baile González2Marina Acera Gómez3Laura Fox4María del Mar Pérez Artigas5Ana Santamaría6María del Carmen Quintela González7Andrés Sánchez Salinas8Joaquina M. Salmerón Camacho9Verónica Illana Álvaro10Zahra Abdallahi-Lefdil11Javier Cornago Navascues12Laura Pardo13Sara Fernández-Luis14Leddy Patricia Vega Suárez15Sara Villar16Patricia Beorlegui-Murillo17Albert Esquirol18Isabel Izquierdo García19Sonia Rodríguez González20Alberto Mussetti21Esperanza Lavilla22Javier Lopez-Marín23Silvia Filaferro24Ángel Cedillo25Leyre Bento26Leyre Bento27Anna Sureda28Anna Sureda29Unidad de Trasplante de Progenitores Hematopoyéticos, Servicio de Hematología, Hospital Clínic de Barcelona, Barcelona, SpainUnidad de Trasplante de Progenitores Hematopoyéticos, Servicio de Hematología, Hospital Clínic de Barcelona, Barcelona, SpainServicio de Hematología, Complejo Asistencial Universitario de Salamanca/IBSAL, Salamanca, SpainServicio de Hematología, Complejo Asistencial Universitario de Salamanca/IBSAL, Salamanca, SpainDepartamento de Hematología, Hospital Universitari Vall d’Hebron, Barcelona, SpainDepartamento de Hematología, Hospital Universitari Vall d’Hebron, Barcelona, SpainDepartamento de Hematología, Hospital Álvaro Cunqueiro, Vigo, Pontevedra, SpainDepartamento de Hematología, Hospital Álvaro Cunqueiro, Vigo, Pontevedra, SpainUnidad de Trasplante de Progenitores Hematopoyéticos, H.C.U. Virgen de la Arrixaca, Murcia, SpainUnidad de Trasplante de Progenitores Hematopoyéticos, H.C.U. Virgen de la Arrixaca, Murcia, SpainDepartamento de Hematología, Hospital Universitario de la Princesa, Madrid, SpainDepartamento de Hematología, Hospital Universitario de la Princesa, Madrid, SpainDepartamento de Hematología, Hospital Universitario Fundación Jiménez Díaz, Madrid, SpainDepartamento de Hematología, Hospital Universitario Fundación Jiménez Díaz, Madrid, SpainUnidad de Trasplante de Progenitores Hematopoyéticos, Servicio de Hematología, Hospital Universitario Marqués de Valdecilla, Santander, SpainUnidad de Trasplante de Progenitores Hematopoyéticos, Servicio de Hematología, Hospital Universitario Marqués de Valdecilla, Santander, SpainDepartamento de Hematología, Clínica Universidad de Navarra, Pamplona, SpainDepartamento de Hematología, Clínica Universidad de Navarra, Pamplona, Spain0Servicio de Hematología, Hospital de la Santa Creu i Sant Pau, IIB-Sant Pau and Jose Carreras Leukemia Research Institute, Universitat Autonoma of Barcelona, Barcelona, Spain1Departamento de Hematología, Hospital Miguel Servet, Zaragoza, Spain2Institut Català d’Oncologia - Hospital Duran i Reynals, IDIBELL, Universitat de Barcelona, Barcelona, Spain2Institut Català d’Oncologia - Hospital Duran i Reynals, IDIBELL, Universitat de Barcelona, Barcelona, Spain3Servicio de Hematología, Hospital Universitario Lucus Augusti, Lugo, Spain4Hospital Universitario de Alicante, Alicante, Spain5Grupo Español de Trasplante de Progenitores Hematopoyéticos y Terapia Celular, Madrid, Spain5Grupo Español de Trasplante de Progenitores Hematopoyéticos y Terapia Celular, Madrid, Spain5Grupo Español de Trasplante de Progenitores Hematopoyéticos y Terapia Celular, Madrid, Spain6Departamento de Hematología, Hospital Universitario Son Espases, Palma de Mallorca, Spain2Institut Català d’Oncologia - Hospital Duran i Reynals, IDIBELL, Universitat de Barcelona, Barcelona, Spain5Grupo Español de Trasplante de Progenitores Hematopoyéticos y Terapia Celular, Madrid, SpainIntroductionThis multicenter prospective study sponsored by the Grupo Español de Transplante Hematopoyético y Terapia Celular (GETH-TC) explores the use of frailty assessments in allo-HCT candidates.MethodsFrailty was measured using the HCT Frailty Scale at first consultation and HCT admission in 404 adults from 15 HCT programs in Spain. Based on the results, patients were classified into fit, pre-frail and frail categories. Allo-HCT outcomes were analyzed according to the results obtained from the HCT Frailty Scale. Data was collected prospectively and all patients signed informed consent.ResultsAt first consultation, 102 (26.2%) patients were classified as fit, 248 (61.4%) as pre-frail, and 50 (12.4%) as frail. During the study, 62 (15.2%) patients participated in a pre-habilitation program. Among non-pre-habilitated patients (n=342), the proportion of fit patients decreased from 26.6% to 16.7%, while frail patients increased from 12.7% to 19.9%. In contrast, pre-habilitated patients (n=62) showed improvements, with fit patients increasing from 24.2% to 46.8%, and frail patients decreasing from 9.7% to 3.2%. Multivariate analysis confirmed lower OS (HR 2.52, P=0.002) and higher NRM (HR 2.69, P=0.013) in frail patients at HCT admission compared to fit ones, with a trend towards lower OS in pre-frail patients (HR 1.54, P=0.097).ConclusionThis study highlights the feasibility of incorporating the HCT Frailty Scale into clinical practice, confirms its negative impact of frailty on transplant outcomes, and suggests that frailty is dynamic and potentially reversible through pre-transplant interventions.https://www.frontiersin.org/articles/10.3389/fimmu.2024.1512154/fullfrailty syndromeHCT Frailty Scaleallogeneic-HCTpre-habilitationsurvival |
| spellingShingle | María Queralt Salas María Teresa Solano Mónica Baile González Marina Acera Gómez Laura Fox María del Mar Pérez Artigas Ana Santamaría María del Carmen Quintela González Andrés Sánchez Salinas Joaquina M. Salmerón Camacho Verónica Illana Álvaro Zahra Abdallahi-Lefdil Javier Cornago Navascues Laura Pardo Sara Fernández-Luis Leddy Patricia Vega Suárez Sara Villar Patricia Beorlegui-Murillo Albert Esquirol Isabel Izquierdo García Sonia Rodríguez González Alberto Mussetti Esperanza Lavilla Javier Lopez-Marín Silvia Filaferro Ángel Cedillo Leyre Bento Leyre Bento Anna Sureda Anna Sureda Frailty assessment in adults undergoing allogeneic hematopoietic cell transplantation: insights from a multicenter GETH-TC study to optimize outcomes and care Frontiers in Immunology frailty syndrome HCT Frailty Scale allogeneic-HCT pre-habilitation survival |
| title | Frailty assessment in adults undergoing allogeneic hematopoietic cell transplantation: insights from a multicenter GETH-TC study to optimize outcomes and care |
| title_full | Frailty assessment in adults undergoing allogeneic hematopoietic cell transplantation: insights from a multicenter GETH-TC study to optimize outcomes and care |
| title_fullStr | Frailty assessment in adults undergoing allogeneic hematopoietic cell transplantation: insights from a multicenter GETH-TC study to optimize outcomes and care |
| title_full_unstemmed | Frailty assessment in adults undergoing allogeneic hematopoietic cell transplantation: insights from a multicenter GETH-TC study to optimize outcomes and care |
| title_short | Frailty assessment in adults undergoing allogeneic hematopoietic cell transplantation: insights from a multicenter GETH-TC study to optimize outcomes and care |
| title_sort | frailty assessment in adults undergoing allogeneic hematopoietic cell transplantation insights from a multicenter geth tc study to optimize outcomes and care |
| topic | frailty syndrome HCT Frailty Scale allogeneic-HCT pre-habilitation survival |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1512154/full |
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