A Metapopulation Model Of Granuloma Formation In The Lung During Infection With Mycobacterium Tuberculosis
The immune response to Mycobacterium tuberculosis infection (Mtb) is the formation of unique lesions, called granulomas. How well these granulomas form and function is a key issue that might explain why individuals experience different disease outcomes. The spatial structures of these granulomas are...
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| Format: | Article |
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AIMS Press
2005-07-01
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| Series: | Mathematical Biosciences and Engineering |
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| Online Access: | https://www.aimspress.com/article/doi/10.3934/mbe.2005.2.535 |
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| author | Suman Ganguli David Gammack Denise E. Kirschner |
| author_facet | Suman Ganguli David Gammack Denise E. Kirschner |
| author_sort | Suman Ganguli |
| collection | DOAJ |
| description | The immune response to Mycobacterium tuberculosis infection (Mtb) is the formation of unique lesions, called granulomas. How well these granulomas form and function is a key issue that might explain why individuals experience different disease outcomes. The spatial structures of these granulomas are not well understood. In this paper, we use a metapopulation framework to develop a spatio-temporal model of the immune response to Mtb. Using this model, we are able to investigate the spatial organization of the immune response in the lungs to Mtb. We identify both host and pathogen factors that contribute to successful infection control. Additionally, we identify specific spatial interactions and mechanisms important for successful granuloma formation. These results can be further studied in the experimental setting. |
| format | Article |
| id | doaj-art-3ab22ebac6954f00a55346d2e8776ce1 |
| institution | Kabale University |
| issn | 1551-0018 |
| language | English |
| publishDate | 2005-07-01 |
| publisher | AIMS Press |
| record_format | Article |
| series | Mathematical Biosciences and Engineering |
| spelling | doaj-art-3ab22ebac6954f00a55346d2e8776ce12025-01-24T01:49:00ZengAIMS PressMathematical Biosciences and Engineering1551-00182005-07-012353556010.3934/mbe.2005.2.535A Metapopulation Model Of Granuloma Formation In The Lung During Infection With Mycobacterium TuberculosisSuman Ganguli0David Gammack1Denise E. Kirschner2Biosystems Group, University of California, San Francisco, 513 Parnassus Ave., San Francisco, CA 94143Department of Mathematics, University of Michigan, 525 E. University Ave., Ann Arbor, MI 48109Department of Microbiology and Immunology, University of Michigan Medical School, 1150 Medical Center Drive, Ann Arbor, MI 48109The immune response to Mycobacterium tuberculosis infection (Mtb) is the formation of unique lesions, called granulomas. How well these granulomas form and function is a key issue that might explain why individuals experience different disease outcomes. The spatial structures of these granulomas are not well understood. In this paper, we use a metapopulation framework to develop a spatio-temporal model of the immune response to Mtb. Using this model, we are able to investigate the spatial organization of the immune response in the lungs to Mtb. We identify both host and pathogen factors that contribute to successful infection control. Additionally, we identify specific spatial interactions and mechanisms important for successful granuloma formation. These results can be further studied in the experimental setting.https://www.aimspress.com/article/doi/10.3934/mbe.2005.2.535chemotaxismetapopulationmathematical modeldiffusion.granulomamycobacterium tuberculosis |
| spellingShingle | Suman Ganguli David Gammack Denise E. Kirschner A Metapopulation Model Of Granuloma Formation In The Lung During Infection With Mycobacterium Tuberculosis Mathematical Biosciences and Engineering chemotaxis metapopulation mathematical model diffusion. granuloma mycobacterium tuberculosis |
| title | A Metapopulation Model Of Granuloma Formation In The Lung During Infection With Mycobacterium Tuberculosis |
| title_full | A Metapopulation Model Of Granuloma Formation In The Lung During Infection With Mycobacterium Tuberculosis |
| title_fullStr | A Metapopulation Model Of Granuloma Formation In The Lung During Infection With Mycobacterium Tuberculosis |
| title_full_unstemmed | A Metapopulation Model Of Granuloma Formation In The Lung During Infection With Mycobacterium Tuberculosis |
| title_short | A Metapopulation Model Of Granuloma Formation In The Lung During Infection With Mycobacterium Tuberculosis |
| title_sort | metapopulation model of granuloma formation in the lung during infection with mycobacterium tuberculosis |
| topic | chemotaxis metapopulation mathematical model diffusion. granuloma mycobacterium tuberculosis |
| url | https://www.aimspress.com/article/doi/10.3934/mbe.2005.2.535 |
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