Increased protein expression of interleukin-10 and its signalling molecules in colon cancer progression: potential prognostic and therapeutic targets

Increased protein expression of interleukin-10 and its signalling molecules in colon cancer progression: potential prognostic and therapeutic targets

Abstract Background Interleukin-10 (IL-10) regulates immune responses in solid tumours, but its role in colorectal cancer (CRC) is unclear due to inconsistent findings. Tumour location is a critical prognostic factor, with proximal tumours often linked to worse outcomes. However, the relationship be...

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Main Authors: Akhmed Aslam, Bassem Refaat, Riyad A. Almaimani, Ahmad A. Obaid, Abdulrahman Mujalli, Wesam F. Farrash, Mohamed E. Elzubier, Shakir Idris, Afnan Salaka, Ahmed H. Almalki, Mofareh Y. Alkhaldi, Hassan A. Asiri, Mohammad A. Baqassi, Ali M. Alhanash, Othman M. Hakmi, Faisal Minshawi
Format: Article
Language:English
Published: Springer 2025-04-01
Series:Discover Oncology
Subjects:
Interleukin-10 receptor α
STAT3
Oncogenesis
Biological therapy
Cell cycle
Apoptosis
Online Access:https://doi.org/10.1007/s12672-025-02452-z
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