Vaccinia virus protein C6 is a virulence factor that binds TBK-1 adaptor proteins and inhibits activation of IRF3 and IRF7.

Vaccinia virus protein C6 is a virulence factor that binds TBK-1 adaptor proteins and inhibits activation of IRF3 and IRF7.

Recognition of viruses by pattern recognition receptors (PRRs) causes interferon-β (IFN-β) induction, a key event in the anti-viral innate immune response, and also a target of viral immune evasion. Here the vaccinia virus (VACV) protein C6 is identified as an inhibitor of PRR-induced IFN-β expressi...

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Bibliographic Details
Main Authors: Leonie Unterholzner, Rebecca P Sumner, Marcin Baran, Hongwei Ren, Daniel S Mansur, Nollaig M Bourke, Felix Randow, Geoffrey L Smith, Andrew G Bowie
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-09-01
Series:PLoS Pathogens
Online Access:https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1002247&type=printable
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