Human Cytomegalovirus Immune Evasion of Natural Killer Cells: A Virus for All Seasons?
Human cytomegalovirus (HCMV) is a ubiquitous member of the herpesvirus family, of significant clinical importance, and highly adapted to its host, resulting from millions of years of co-evolution. As a result, the virus systematically subverts almost all aspects of antiviral immune defence to succes...
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| Language: | English |
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MDPI AG
2025-06-01
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| Series: | Pathogens |
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| Online Access: | https://www.mdpi.com/2076-0817/14/7/629 |
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| author | Hannah Preston Rowan Casey Elizabeth Ferris Lauren Kerr-Jones Lauren Jones Farah Latif Mathew Clement Rebecca J. Aicheler Eddie C. Y. Wang Richard J. Stanton Ceri A. Fielding |
| author_facet | Hannah Preston Rowan Casey Elizabeth Ferris Lauren Kerr-Jones Lauren Jones Farah Latif Mathew Clement Rebecca J. Aicheler Eddie C. Y. Wang Richard J. Stanton Ceri A. Fielding |
| author_sort | Hannah Preston |
| collection | DOAJ |
| description | Human cytomegalovirus (HCMV) is a ubiquitous member of the herpesvirus family, of significant clinical importance, and highly adapted to its host, resulting from millions of years of co-evolution. As a result, the virus systematically subverts almost all aspects of antiviral immune defence to successfully establish a lifelong persistent infection, and in the process, dramatically reshapes the phenotype and function of host immunity to both HCMV and other diseases. Natural killer (NK) cells are a critical component of successful herpesvirus control. Here, we discuss their role in modulating HCMV disease and the multitude of ways that HCMV has evolved to prevent and manipulate this process. We also consider how antibody-dependent cellular cytotoxicity by NK cells directed against HCMV might overcome NK immune evasion mechanisms and be useful therapeutically. |
| format | Article |
| id | doaj-art-3aac6a6ed23b410fa257bac7beaac2a1 |
| institution | DOAJ |
| issn | 2076-0817 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj-art-3aac6a6ed23b410fa257bac7beaac2a12025-08-20T03:08:02ZengMDPI AGPathogens2076-08172025-06-0114762910.3390/pathogens14070629Human Cytomegalovirus Immune Evasion of Natural Killer Cells: A Virus for All Seasons?Hannah Preston0Rowan Casey1Elizabeth Ferris2Lauren Kerr-Jones3Lauren Jones4Farah Latif5Mathew Clement6Rebecca J. Aicheler7Eddie C. Y. Wang8Richard J. Stanton9Ceri A. Fielding10Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, UKDivision of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, UKDivision of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, UKDivision of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, UKDivision of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, UKDivision of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, UKDivision of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, UKSchool of Sport and Health Sciences, Cardiff Metropolitan University, Cardiff CF5 2YB, UKDivision of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, UKDivision of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, UKDivision of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, UKHuman cytomegalovirus (HCMV) is a ubiquitous member of the herpesvirus family, of significant clinical importance, and highly adapted to its host, resulting from millions of years of co-evolution. As a result, the virus systematically subverts almost all aspects of antiviral immune defence to successfully establish a lifelong persistent infection, and in the process, dramatically reshapes the phenotype and function of host immunity to both HCMV and other diseases. Natural killer (NK) cells are a critical component of successful herpesvirus control. Here, we discuss their role in modulating HCMV disease and the multitude of ways that HCMV has evolved to prevent and manipulate this process. We also consider how antibody-dependent cellular cytotoxicity by NK cells directed against HCMV might overcome NK immune evasion mechanisms and be useful therapeutically.https://www.mdpi.com/2076-0817/14/7/629cytomegalovirusnatural killer cellimmune evasion |
| spellingShingle | Hannah Preston Rowan Casey Elizabeth Ferris Lauren Kerr-Jones Lauren Jones Farah Latif Mathew Clement Rebecca J. Aicheler Eddie C. Y. Wang Richard J. Stanton Ceri A. Fielding Human Cytomegalovirus Immune Evasion of Natural Killer Cells: A Virus for All Seasons? Pathogens cytomegalovirus natural killer cell immune evasion |
| title | Human Cytomegalovirus Immune Evasion of Natural Killer Cells: A Virus for All Seasons? |
| title_full | Human Cytomegalovirus Immune Evasion of Natural Killer Cells: A Virus for All Seasons? |
| title_fullStr | Human Cytomegalovirus Immune Evasion of Natural Killer Cells: A Virus for All Seasons? |
| title_full_unstemmed | Human Cytomegalovirus Immune Evasion of Natural Killer Cells: A Virus for All Seasons? |
| title_short | Human Cytomegalovirus Immune Evasion of Natural Killer Cells: A Virus for All Seasons? |
| title_sort | human cytomegalovirus immune evasion of natural killer cells a virus for all seasons |
| topic | cytomegalovirus natural killer cell immune evasion |
| url | https://www.mdpi.com/2076-0817/14/7/629 |
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