Association between inflammatory burden index and risk of heart failure: evidence from NHANES 2003–2017
Abstract Background Systemic inflammation contributes to the progression of heart failure (HF). This study aims to investigate the association between inflammatory burden index (IBI) and HF risk. Methods In this cross-sectional study of NHANES 2003–2017, data from 19,856 participants were analyzed,...
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BMC
2025-04-01
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| Series: | BMC Cardiovascular Disorders |
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| Online Access: | https://doi.org/10.1186/s12872-025-04781-x |
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| author | Li-Xin Yun Wan-Zhong Huang Changjing He Yuan Huang Hua-Feng Yang Qiang Su Da-Zhi Lan Yang-Chun Liu |
| author_facet | Li-Xin Yun Wan-Zhong Huang Changjing He Yuan Huang Hua-Feng Yang Qiang Su Da-Zhi Lan Yang-Chun Liu |
| author_sort | Li-Xin Yun |
| collection | DOAJ |
| description | Abstract Background Systemic inflammation contributes to the progression of heart failure (HF). This study aims to investigate the association between inflammatory burden index (IBI) and HF risk. Methods In this cross-sectional study of NHANES 2003–2017, data from 19,856 participants were analyzed, including 652 participants with HF and 19,204 without HF. Participants were categorized into quartiles based on IBI levels (Q1–Q4). The risk of HF across these quartiles was assessed with adjustment for potential confounders and restricted cubic spline analyses were used to evaluate dose-response relationships. Results Our results show that participants with HF have higher IBI levels compared to those without HF (2.66 ± 0.27 vs. 1.05 ± 0.03, p < 0.001). The prevalence of HF increases with higher IBI quartiles: Quartile 1 (1.2%), Quartile 2 (1.33%), Quartile 3 (2.60%), and Quartile 4 (4.37%) (p < 0.001). After adjusting for potential confounders, the risk of HF remained elevated across the quartiles: Quartile 2 (odds ratio [OR] = 0.72, 95% confidence interval [CI]: 0.48–1.10), Quartile 3 (OR = 1.06, 95% CI: 0.70–1.61), and Quartile 4 (OR = 1.46, 95% CI: 1.02–2.10) compared to Quartile 1. Restricted cubic spline analysis further confirmed a substantial positive-linear correlation between IBI and HF risk. Conclusion Higher levels of IBI are related to a high risk of HF, independent of traditional risk factors. These results suggest that IBI could be a useful parameter for identifying individuals at higher risk of HF. Clinical trial number Not applicable. |
| format | Article |
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| institution | OA Journals |
| issn | 1471-2261 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | BMC |
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| series | BMC Cardiovascular Disorders |
| spelling | doaj-art-3aaac700ecb848258a0eaa077088dc392025-08-20T02:30:19ZengBMCBMC Cardiovascular Disorders1471-22612025-04-0125111010.1186/s12872-025-04781-xAssociation between inflammatory burden index and risk of heart failure: evidence from NHANES 2003–2017Li-Xin Yun0Wan-Zhong Huang1Changjing He2Yuan Huang3Hua-Feng Yang4Qiang Su5Da-Zhi Lan6Yang-Chun Liu7Department of Cardiology, The Second Affiliated Hospital of Guangxi Medical UniversityDepartment of Cardiology, Jiangbin Hospital of Guangxi Zhuang Autonomous RegionDepartment of Pediatric Surgery, The Affiliated Hospital of Youjiang Medical University for NationalitiesDepartment of Cardiology, Jiangbin Hospital of Guangxi Zhuang Autonomous RegionCardiothoracic Surgery Intensive Care Unit, The First Affiliated Hospital of Guangxi Medical UniversityDepartment of Cardiology, Jiangbin Hospital of Guangxi Zhuang Autonomous RegionSchool of Public Health and Management, Guangxi University of Chinese MedicineCardiothoracic Surgery Intensive Care Unit, The First Affiliated Hospital of Guangxi Medical UniversityAbstract Background Systemic inflammation contributes to the progression of heart failure (HF). This study aims to investigate the association between inflammatory burden index (IBI) and HF risk. Methods In this cross-sectional study of NHANES 2003–2017, data from 19,856 participants were analyzed, including 652 participants with HF and 19,204 without HF. Participants were categorized into quartiles based on IBI levels (Q1–Q4). The risk of HF across these quartiles was assessed with adjustment for potential confounders and restricted cubic spline analyses were used to evaluate dose-response relationships. Results Our results show that participants with HF have higher IBI levels compared to those without HF (2.66 ± 0.27 vs. 1.05 ± 0.03, p < 0.001). The prevalence of HF increases with higher IBI quartiles: Quartile 1 (1.2%), Quartile 2 (1.33%), Quartile 3 (2.60%), and Quartile 4 (4.37%) (p < 0.001). After adjusting for potential confounders, the risk of HF remained elevated across the quartiles: Quartile 2 (odds ratio [OR] = 0.72, 95% confidence interval [CI]: 0.48–1.10), Quartile 3 (OR = 1.06, 95% CI: 0.70–1.61), and Quartile 4 (OR = 1.46, 95% CI: 1.02–2.10) compared to Quartile 1. Restricted cubic spline analysis further confirmed a substantial positive-linear correlation between IBI and HF risk. Conclusion Higher levels of IBI are related to a high risk of HF, independent of traditional risk factors. These results suggest that IBI could be a useful parameter for identifying individuals at higher risk of HF. Clinical trial number Not applicable.https://doi.org/10.1186/s12872-025-04781-xAssociationInflammatory burden indexRiskHeart failureNHANES |
| spellingShingle | Li-Xin Yun Wan-Zhong Huang Changjing He Yuan Huang Hua-Feng Yang Qiang Su Da-Zhi Lan Yang-Chun Liu Association between inflammatory burden index and risk of heart failure: evidence from NHANES 2003–2017 BMC Cardiovascular Disorders Association Inflammatory burden index Risk Heart failure NHANES |
| title | Association between inflammatory burden index and risk of heart failure: evidence from NHANES 2003–2017 |
| title_full | Association between inflammatory burden index and risk of heart failure: evidence from NHANES 2003–2017 |
| title_fullStr | Association between inflammatory burden index and risk of heart failure: evidence from NHANES 2003–2017 |
| title_full_unstemmed | Association between inflammatory burden index and risk of heart failure: evidence from NHANES 2003–2017 |
| title_short | Association between inflammatory burden index and risk of heart failure: evidence from NHANES 2003–2017 |
| title_sort | association between inflammatory burden index and risk of heart failure evidence from nhanes 2003 2017 |
| topic | Association Inflammatory burden index Risk Heart failure NHANES |
| url | https://doi.org/10.1186/s12872-025-04781-x |
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