Reduced T-Cell stemness underlies Th17 expansion and graft dysfunction in kidney transplant recipients

Reduced T-Cell stemness underlies Th17 expansion and graft dysfunction in kidney transplant recipients

IntroductionEnd-stage renal disease (ESRD) is increasing worldwide, and although kidney transplantation improves survival, long-term graft loss–driven mainly by immune-mediated rejection–remains common. We aimed to delineate immune mechanisms that distinguish recipients with stable versus impaired g...

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Bibliographic Details
Main Authors: Chang Liu, Hao Jiang, Andu Zhu, Chen Xu, Zhenfan Wang, Guocai Mao, Minjun Jiang, Jianchun Chen, Zheng Ma, Jiaqian Qi, Zhijun Cao
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Genetics
Subjects:
T-cell stemness
Th17 cells
S100 proteins
kidney transplantation
immune regulation
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2025.1588941/full
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