TGM6 is a helminth secretory product that mimics TGF-β binding to TGFBR2 to antagonize signaling in fibroblasts

TGM6 is a helminth secretory product that mimics TGF-β binding to TGFBR2 to antagonize signaling in fibroblasts

Abstract TGM6 is a natural antagonist of mammalian TGF-β signaling produced by the murine helminth parasite Heligmosomoides polygyrus. It differs from the previously described agonist, TGM1 (TGF-β Mimic-1), in that it lacks domains 1/2 that bind TGFBR1. It nonetheless retains TGFBR2 binding through...

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Main Authors: Stephen E. White, Tristin A. Schwartze, Ananya Mukundan, Christina Schoenherr, Shashi P. Singh, Maarten van Dinther, Kyle T. Cunningham, Madeleine P. J. White, Tiffany Campion, John Pritchard, Cynthia S. Hinck, Peter ten Dijke, Gareth J. Inman, Rick M. Maizels, Andrew P. Hinck
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-56954-z
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