Erdheim-Chester Disease and Small Lymphocytic Lymphoma Collision Tumour Presenting as a Perirenal Mass
Background. Erdheim-Chester disease is a rare histiocytic neoplasm associated with MAPK pathway mutations. Disease manifestation is variable often involving many different organs, mainly bone, retroperitoneum, the heart, and the central nervous system. Histological findings include foamy histiocytes...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Case Reports in Pathology |
| Online Access: | http://dx.doi.org/10.1155/2020/3081824 |
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| author | Antonio Maietta Maryam Razmpoosh |
| author_facet | Antonio Maietta Maryam Razmpoosh |
| author_sort | Antonio Maietta |
| collection | DOAJ |
| description | Background. Erdheim-Chester disease is a rare histiocytic neoplasm associated with MAPK pathway mutations. Disease manifestation is variable often involving many different organs, mainly bone, retroperitoneum, the heart, and the central nervous system. Histological findings include foamy histiocytes in a fibrous stroma with scattered inflammatory infiltrate. Histiocytes are CD68 positive and S100 negative. Case Report. We report a case of Erdheim-Chester disease associated with small lymphocytic lymphoma presenting as a perirenal mass with a review of the recent literature. Conclusions. Erdheim-Chester disease rarely can be associated with other cancers, namely myeloid neoplasms. We report a case of Erdheim-Chester disease presenting with small lymphocytic lymphoma as a perirenal mass. The association of Erdheim-Chester disease with lymphoproliferative disorders needs to be elucidated. |
| format | Article |
| id | doaj-art-3aa7262a330a4839b504b12cff0cc23b |
| institution | Kabale University |
| issn | 2090-6781 2090-679X |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Pathology |
| spelling | doaj-art-3aa7262a330a4839b504b12cff0cc23b2025-02-03T06:43:38ZengWileyCase Reports in Pathology2090-67812090-679X2020-01-01202010.1155/2020/30818243081824Erdheim-Chester Disease and Small Lymphocytic Lymphoma Collision Tumour Presenting as a Perirenal MassAntonio Maietta0Maryam Razmpoosh1Centre Hospitalier de l’université de Montréal (CHUM), 1100, rue Sanguinet, 7th Floor, F Pavillon, (Québec), Montréal, H2X 0C1, CanadaCentre Hospitalier de l’université de Montréal (CHUM), 1100, rue Sanguinet, 7th Floor, F Pavillon, (Québec), Montréal, H2X 0C1, CanadaBackground. Erdheim-Chester disease is a rare histiocytic neoplasm associated with MAPK pathway mutations. Disease manifestation is variable often involving many different organs, mainly bone, retroperitoneum, the heart, and the central nervous system. Histological findings include foamy histiocytes in a fibrous stroma with scattered inflammatory infiltrate. Histiocytes are CD68 positive and S100 negative. Case Report. We report a case of Erdheim-Chester disease associated with small lymphocytic lymphoma presenting as a perirenal mass with a review of the recent literature. Conclusions. Erdheim-Chester disease rarely can be associated with other cancers, namely myeloid neoplasms. We report a case of Erdheim-Chester disease presenting with small lymphocytic lymphoma as a perirenal mass. The association of Erdheim-Chester disease with lymphoproliferative disorders needs to be elucidated.http://dx.doi.org/10.1155/2020/3081824 |
| spellingShingle | Antonio Maietta Maryam Razmpoosh Erdheim-Chester Disease and Small Lymphocytic Lymphoma Collision Tumour Presenting as a Perirenal Mass Case Reports in Pathology |
| title | Erdheim-Chester Disease and Small Lymphocytic Lymphoma Collision Tumour Presenting as a Perirenal Mass |
| title_full | Erdheim-Chester Disease and Small Lymphocytic Lymphoma Collision Tumour Presenting as a Perirenal Mass |
| title_fullStr | Erdheim-Chester Disease and Small Lymphocytic Lymphoma Collision Tumour Presenting as a Perirenal Mass |
| title_full_unstemmed | Erdheim-Chester Disease and Small Lymphocytic Lymphoma Collision Tumour Presenting as a Perirenal Mass |
| title_short | Erdheim-Chester Disease and Small Lymphocytic Lymphoma Collision Tumour Presenting as a Perirenal Mass |
| title_sort | erdheim chester disease and small lymphocytic lymphoma collision tumour presenting as a perirenal mass |
| url | http://dx.doi.org/10.1155/2020/3081824 |
| work_keys_str_mv | AT antoniomaietta erdheimchesterdiseaseandsmalllymphocyticlymphomacollisiontumourpresentingasaperirenalmass AT maryamrazmpoosh erdheimchesterdiseaseandsmalllymphocyticlymphomacollisiontumourpresentingasaperirenalmass |