Intestinal Microbiota as an Alternative Therapeutic Target for Epilepsy
Epilepsy is one of the most widespread serious neurological disorders, and an aetiological explanation has not been fully identified. In recent decades, a growing body of evidence has highlighted the influential role of autoimmune mechanisms in the progression of epilepsy. The hygiene hypothesis dra...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Canadian Journal of Infectious Diseases and Medical Microbiology |
| Online Access: | http://dx.doi.org/10.1155/2016/9032809 |
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| _version_ | 1850218311962329088 |
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| author | Jiaying Wu Yuyu Zhang Hongyu Yang Yuefeng Rao Jing Miao Xiaoyang Lu |
| author_facet | Jiaying Wu Yuyu Zhang Hongyu Yang Yuefeng Rao Jing Miao Xiaoyang Lu |
| author_sort | Jiaying Wu |
| collection | DOAJ |
| description | Epilepsy is one of the most widespread serious neurological disorders, and an aetiological explanation has not been fully identified. In recent decades, a growing body of evidence has highlighted the influential role of autoimmune mechanisms in the progression of epilepsy. The hygiene hypothesis draws people’s attention to the association between gut microbes and the onset of multiple immune disorders. It is also believed that, in addition to influencing digestive system function, symbiotic microbiota can bidirectionally and reversibly impact the programming of extraintestinal pathogenic immune responses during autoimmunity. Herein, we investigate the concept that the diversity of parasitifer sensitivity to commensal microbes and the specific constitution of the intestinal microbiota might impact host susceptibility to epilepsy through promotion of Th17 cell populations in the central nervous system (CNS). |
| format | Article |
| id | doaj-art-3aa6ea3dc2dc4a7991e608a8d1985cc3 |
| institution | OA Journals |
| issn | 1712-9532 1918-1493 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Infectious Diseases and Medical Microbiology |
| spelling | doaj-art-3aa6ea3dc2dc4a7991e608a8d1985cc32025-08-20T02:07:47ZengWileyCanadian Journal of Infectious Diseases and Medical Microbiology1712-95321918-14932016-01-01201610.1155/2016/90328099032809Intestinal Microbiota as an Alternative Therapeutic Target for EpilepsyJiaying Wu0Yuyu Zhang1Hongyu Yang2Yuefeng Rao3Jing Miao4Xiaoyang Lu5The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, ChinaNingbo Medical Treatment Center Lihuili Hospital, Ningbo, ChinaThe First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, ChinaThe First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, ChinaThe First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, ChinaThe First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, ChinaEpilepsy is one of the most widespread serious neurological disorders, and an aetiological explanation has not been fully identified. In recent decades, a growing body of evidence has highlighted the influential role of autoimmune mechanisms in the progression of epilepsy. The hygiene hypothesis draws people’s attention to the association between gut microbes and the onset of multiple immune disorders. It is also believed that, in addition to influencing digestive system function, symbiotic microbiota can bidirectionally and reversibly impact the programming of extraintestinal pathogenic immune responses during autoimmunity. Herein, we investigate the concept that the diversity of parasitifer sensitivity to commensal microbes and the specific constitution of the intestinal microbiota might impact host susceptibility to epilepsy through promotion of Th17 cell populations in the central nervous system (CNS).http://dx.doi.org/10.1155/2016/9032809 |
| spellingShingle | Jiaying Wu Yuyu Zhang Hongyu Yang Yuefeng Rao Jing Miao Xiaoyang Lu Intestinal Microbiota as an Alternative Therapeutic Target for Epilepsy Canadian Journal of Infectious Diseases and Medical Microbiology |
| title | Intestinal Microbiota as an Alternative Therapeutic Target for Epilepsy |
| title_full | Intestinal Microbiota as an Alternative Therapeutic Target for Epilepsy |
| title_fullStr | Intestinal Microbiota as an Alternative Therapeutic Target for Epilepsy |
| title_full_unstemmed | Intestinal Microbiota as an Alternative Therapeutic Target for Epilepsy |
| title_short | Intestinal Microbiota as an Alternative Therapeutic Target for Epilepsy |
| title_sort | intestinal microbiota as an alternative therapeutic target for epilepsy |
| url | http://dx.doi.org/10.1155/2016/9032809 |
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