Immunohistochemical Expression of Basement Membrane Laminin in Histological Grades of Oral Squamous Cell Carcinoma: A Semiquantitative Analysis
Background: Oral squamous cell carcinoma (OSCC) is a prevalent malignancy characterized by varying histological grades. Basement membrane laminin expression plays a crucial role in tumor invasion and progression. This study aimed to assess the immunohistochemical expression of basement membrane lami...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2024-12-01
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| Series: | Journal of Pharmacy and Bioallied Sciences |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/jpbs.jpbs_944_24 |
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| Summary: | Background:
Oral squamous cell carcinoma (OSCC) is a prevalent malignancy characterized by varying histological grades. Basement membrane laminin expression plays a crucial role in tumor invasion and progression. This study aimed to assess the immunohistochemical expression of basement membrane laminin in different histological grades of OSCC.
Materials and Methods:
Archival tissue samples of OSCC from 60 patients were categorized into well-differentiated, moderately differentiated, and poorly differentiated grades. Immunohistochemistry was performed using anti-laminin antibodies, and staining intensity was semiquantitatively analyzed using a scoring system.
Results:
The immunohistochemical analysis revealed varying levels of laminin expression across different histological grades of OSCC. Well-differentiated tumors showed an average staining intensity score of 7.2 (SD ± 1.5), moderately differentiated tumors had a score of 5.8 (SD ± 1.2), and poorly differentiated tumors exhibited a score of 4.3 (SD ± 0.9). Statistical analysis indicated a significant difference in laminin expression between histological grades (P < 0.001).
Conclusion:
Our findings demonstrate a progressive decrease in basement membrane laminin expression with an increasing histological grade of OSCC. This suggests that laminin may be a potential biomarker for assessing tumor aggressiveness and prognosis in oral squamous cell carcinoma. |
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| ISSN: | 0976-4879 0975-7406 |