The role of osteopontin in patients with type 2 diabetes and cognitive impairment
Background — type 2 diabetes is associated with obesity and cardiovascular disease; in combination with dysmetabolic and proinflammatory pathophysiological mechanisms, it leads to cognitive impairment. Objective — analysis of the osteopontin role in formation of cognitive disorders in patients with...
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| Format: | Article |
| Language: | English |
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Limited liability company «Science and Innovations» (Saratov)
2021-12-01
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| Series: | Russian Open Medical Journal |
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| Online Access: | https://romj.org/node/425 |
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| author | Maria V. Matveeva Yulia G. Samoilova Oksana A. Oleynik Olga S. Tonkikh Daria V. Podchinenova Dmitry A. Kudlay |
| author_facet | Maria V. Matveeva Yulia G. Samoilova Oksana A. Oleynik Olga S. Tonkikh Daria V. Podchinenova Dmitry A. Kudlay |
| author_sort | Maria V. Matveeva |
| collection | DOAJ |
| description | Background — type 2 diabetes is associated with obesity and cardiovascular disease; in combination with dysmetabolic and proinflammatory pathophysiological mechanisms, it leads to cognitive impairment.
Objective — analysis of the osteopontin role in formation of cognitive disorders in patients with type 2 diabetes.
Material and Methods — the study complies with generally accepted ethical rules; it was approved by the Ethics Committee of Siberian State Medical University. It involved 50 patients with type 2 diabetes, who were divided into groups depending on the presence of cognitive impairment; the control group consisted of 25 subjects. All patients underwent general clinical examination, blood sampling for biochemical parameters, and plasma osteopontin content assessment. Magnetic resonance imaging (MRI) was performed on SIGNA Creator E magnetic resonance imaging system, GE Healthcare, 1.5 T, China. The employed techniques included dynamic contrast and arterial spin labeling, proton spectroscopy, tractography. SPSS Statistics software was used for statistical analysis.
Results — osteopontin levels were higher in patients with excess weight, hyperglycemia, hyperuricemia, dyslipidemia, and cognitive impairment; and in neuroimaging studies with microangiopathy, based on perfusion MRI, with impaired white matter integration, as well as with neurometabolism of choline, creatine and phosphocreatine metabolites in the hippocampus, as well as their NAA/Cr, NAA/Cho, Cho/Cr ratios (p≤0.05).
Conclusion — patients with type 2 diabetes, along with cognitive and metabolic disorders, exhibited elevated levels of osteopontin, which was also associated with impaired cerebral vascularization in general, and white matter organization, as well as neurometabolism in the hippocampus. |
| format | Article |
| id | doaj-art-3aa3dca59fdb4430bf396919d60ae020 |
| institution | OA Journals |
| issn | 2304-3415 |
| language | English |
| publishDate | 2021-12-01 |
| publisher | Limited liability company «Science and Innovations» (Saratov) |
| record_format | Article |
| series | Russian Open Medical Journal |
| spelling | doaj-art-3aa3dca59fdb4430bf396919d60ae0202025-08-20T02:32:15ZengLimited liability company «Science and Innovations» (Saratov)Russian Open Medical Journal2304-34152021-12-01104e040810.15275/rusomj.2021.0408The role of osteopontin in patients with type 2 diabetes and cognitive impairmentMaria V. MatveevaYulia G. SamoilovaOksana A. OleynikOlga S. TonkikhDaria V. PodchinenovaDmitry A. KudlayBackground — type 2 diabetes is associated with obesity and cardiovascular disease; in combination with dysmetabolic and proinflammatory pathophysiological mechanisms, it leads to cognitive impairment. Objective — analysis of the osteopontin role in formation of cognitive disorders in patients with type 2 diabetes. Material and Methods — the study complies with generally accepted ethical rules; it was approved by the Ethics Committee of Siberian State Medical University. It involved 50 patients with type 2 diabetes, who were divided into groups depending on the presence of cognitive impairment; the control group consisted of 25 subjects. All patients underwent general clinical examination, blood sampling for biochemical parameters, and plasma osteopontin content assessment. Magnetic resonance imaging (MRI) was performed on SIGNA Creator E magnetic resonance imaging system, GE Healthcare, 1.5 T, China. The employed techniques included dynamic contrast and arterial spin labeling, proton spectroscopy, tractography. SPSS Statistics software was used for statistical analysis. Results — osteopontin levels were higher in patients with excess weight, hyperglycemia, hyperuricemia, dyslipidemia, and cognitive impairment; and in neuroimaging studies with microangiopathy, based on perfusion MRI, with impaired white matter integration, as well as with neurometabolism of choline, creatine and phosphocreatine metabolites in the hippocampus, as well as their NAA/Cr, NAA/Cho, Cho/Cr ratios (p≤0.05). Conclusion — patients with type 2 diabetes, along with cognitive and metabolic disorders, exhibited elevated levels of osteopontin, which was also associated with impaired cerebral vascularization in general, and white matter organization, as well as neurometabolism in the hippocampus.https://romj.org/node/425type 2 diabetesosteopontinmagnetic resonance perfusionmagnetic resonance spectroscopycognitive impairment |
| spellingShingle | Maria V. Matveeva Yulia G. Samoilova Oksana A. Oleynik Olga S. Tonkikh Daria V. Podchinenova Dmitry A. Kudlay The role of osteopontin in patients with type 2 diabetes and cognitive impairment Russian Open Medical Journal type 2 diabetes osteopontin magnetic resonance perfusion magnetic resonance spectroscopy cognitive impairment |
| title | The role of osteopontin in patients with type 2 diabetes and cognitive impairment |
| title_full | The role of osteopontin in patients with type 2 diabetes and cognitive impairment |
| title_fullStr | The role of osteopontin in patients with type 2 diabetes and cognitive impairment |
| title_full_unstemmed | The role of osteopontin in patients with type 2 diabetes and cognitive impairment |
| title_short | The role of osteopontin in patients with type 2 diabetes and cognitive impairment |
| title_sort | role of osteopontin in patients with type 2 diabetes and cognitive impairment |
| topic | type 2 diabetes osteopontin magnetic resonance perfusion magnetic resonance spectroscopy cognitive impairment |
| url | https://romj.org/node/425 |
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