Unmasking the Hidden Threat: Anorectal Lesion Revealed as Malignant Melanoma in a Resected Rectal Polyp
Melanoma is a malignant neoplasm arising from melanocytes, primarily affecting the skin. Anorectal mucosal melanoma (ARMM) is an exceedingly rare and aggressive cancer with a poor prognosis. We present a case of a middle aged caucasian male patient with a rectal polyp, bleeding, and discomfort durin...
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| Language: | English |
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Wolters Kluwer Medknow Publications
2025-05-01
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| Series: | Medical Journal of Dr. D.Y. Patil Vidyapeeth |
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| Online Access: | https://journals.lww.com/10.4103/mjdrdypu.mjdrdypu_153_24 |
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| author | Padmakar Bardapurkar Mangesh Londhe Sushama G. Gurwale Pranjali Nibe Prachi Chouhan |
| author_facet | Padmakar Bardapurkar Mangesh Londhe Sushama G. Gurwale Pranjali Nibe Prachi Chouhan |
| author_sort | Padmakar Bardapurkar |
| collection | DOAJ |
| description | Melanoma is a malignant neoplasm arising from melanocytes, primarily affecting the skin. Anorectal mucosal melanoma (ARMM) is an exceedingly rare and aggressive cancer with a poor prognosis. We present a case of a middle aged caucasian male patient with a rectal polyp, bleeding, and discomfort during defecation. A per rectal examination revealed a protruding mass, leading to a diagnosis of a pedunculated rectal mass. Imaging studies confirmed a large mass along the anal canal. The mass was surgically resected, and histopathological examination revealed neoplastic cells consistent with malignant melanoma. Immunohistochemical marker studies confirmed the diagnosis. ARMM is often misdiagnosed due to its rarity and nonspecific symptoms, leading to delayed diagnosis and poor outcomes. Computed tomography (CT) scans aid in assessing disease extent, while immunohistochemical markers assist in confirming the diagnosis. Wide local excision is the mainstay of treatment, although its impact on prognosis is limited due to the systemic nature of the disease. Lymph node dissection may be necessary in specific cases. Further research is required to enhance understanding and establish standardized management approaches for ARMM. |
| format | Article |
| id | doaj-art-3aa16bd99c804d6eb87cf7b2881dc319 |
| institution | Kabale University |
| issn | 2589-8302 2589-8310 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Medical Journal of Dr. D.Y. Patil Vidyapeeth |
| spelling | doaj-art-3aa16bd99c804d6eb87cf7b2881dc3192025-08-20T03:24:47ZengWolters Kluwer Medknow PublicationsMedical Journal of Dr. D.Y. Patil Vidyapeeth2589-83022589-83102025-05-0118352953210.4103/mjdrdypu.mjdrdypu_153_24Unmasking the Hidden Threat: Anorectal Lesion Revealed as Malignant Melanoma in a Resected Rectal PolypPadmakar BardapurkarMangesh LondheSushama G. GurwalePranjali NibePrachi ChouhanMelanoma is a malignant neoplasm arising from melanocytes, primarily affecting the skin. Anorectal mucosal melanoma (ARMM) is an exceedingly rare and aggressive cancer with a poor prognosis. We present a case of a middle aged caucasian male patient with a rectal polyp, bleeding, and discomfort during defecation. A per rectal examination revealed a protruding mass, leading to a diagnosis of a pedunculated rectal mass. Imaging studies confirmed a large mass along the anal canal. The mass was surgically resected, and histopathological examination revealed neoplastic cells consistent with malignant melanoma. Immunohistochemical marker studies confirmed the diagnosis. ARMM is often misdiagnosed due to its rarity and nonspecific symptoms, leading to delayed diagnosis and poor outcomes. Computed tomography (CT) scans aid in assessing disease extent, while immunohistochemical markers assist in confirming the diagnosis. Wide local excision is the mainstay of treatment, although its impact on prognosis is limited due to the systemic nature of the disease. Lymph node dissection may be necessary in specific cases. Further research is required to enhance understanding and establish standardized management approaches for ARMM.https://journals.lww.com/10.4103/mjdrdypu.mjdrdypu_153_24anorectal melanomaimmunohistochemistrymalignancymalignant melanomarare |
| spellingShingle | Padmakar Bardapurkar Mangesh Londhe Sushama G. Gurwale Pranjali Nibe Prachi Chouhan Unmasking the Hidden Threat: Anorectal Lesion Revealed as Malignant Melanoma in a Resected Rectal Polyp Medical Journal of Dr. D.Y. Patil Vidyapeeth anorectal melanoma immunohistochemistry malignancy malignant melanoma rare |
| title | Unmasking the Hidden Threat: Anorectal Lesion Revealed as Malignant Melanoma in a Resected Rectal Polyp |
| title_full | Unmasking the Hidden Threat: Anorectal Lesion Revealed as Malignant Melanoma in a Resected Rectal Polyp |
| title_fullStr | Unmasking the Hidden Threat: Anorectal Lesion Revealed as Malignant Melanoma in a Resected Rectal Polyp |
| title_full_unstemmed | Unmasking the Hidden Threat: Anorectal Lesion Revealed as Malignant Melanoma in a Resected Rectal Polyp |
| title_short | Unmasking the Hidden Threat: Anorectal Lesion Revealed as Malignant Melanoma in a Resected Rectal Polyp |
| title_sort | unmasking the hidden threat anorectal lesion revealed as malignant melanoma in a resected rectal polyp |
| topic | anorectal melanoma immunohistochemistry malignancy malignant melanoma rare |
| url | https://journals.lww.com/10.4103/mjdrdypu.mjdrdypu_153_24 |
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