Forced degradation of metronidazole, oxytetracycline and furazolidone studies using High Performance Liquid Chromatography
The study describes the development of a HPLC -DAD method for the estimation of oxytetracycline and furazolidone in Enteroguard M - powder. The proposed method utilizes a Betasil C 18 column, (4.6 x 250 mm, 5 µm), at 300 C, optimum mobile phase consisted of 40 mM phosphate buffer (pH=7.5): methanol...
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| Format: | Article |
| Language: | English |
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Asociaţia Naţională a Fabricanţilor de Produse de Uz Veterinar
2014-06-01
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| Series: | Medicamentul Veterinar |
| Online Access: | http://www.veterinarypharmacon.com/docs/1344-2014-VD-8-1-ART.8.EN.pdf |
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| _version_ | 1849247075128049664 |
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| author | Violeta Tauber (Giugiu), Viorica Chiurciu |
| author_facet | Violeta Tauber (Giugiu), Viorica Chiurciu |
| author_sort | Violeta Tauber (Giugiu), |
| collection | DOAJ |
| description | The study describes the development of a HPLC -DAD method for the estimation of oxytetracycline and furazolidone in Enteroguard M - powder. The proposed method utilizes a Betasil C 18 column, (4.6 x 250 mm, 5 µm), at 300 C, optimum mobile phase consisted of 40 mM phosphate buffer (pH=7.5): methanol in gradient elution. The flow rate was optimized to 1mL/min and the detection was carried at 254 nm. The drug substance was exposed to temperature, light, oxidants, acid and basic hydrolysis, and the resultant samples were analyzed by the proposed method. |
| format | Article |
| id | doaj-art-3a9ca0a1b4e549a18699e70e50b6071a |
| institution | Kabale University |
| issn | 1843-9527 2069-2463 |
| language | English |
| publishDate | 2014-06-01 |
| publisher | Asociaţia Naţională a Fabricanţilor de Produse de Uz Veterinar |
| record_format | Article |
| series | Medicamentul Veterinar |
| spelling | doaj-art-3a9ca0a1b4e549a18699e70e50b6071a2025-08-20T03:58:19ZengAsociaţia Naţională a Fabricanţilor de Produse de Uz VeterinarMedicamentul Veterinar1843-95272069-24632014-06-01817379Forced degradation of metronidazole, oxytetracycline and furazolidone studies using High Performance Liquid ChromatographyVioleta Tauber (Giugiu), 0Viorica Chiurciu1Romvac Company SA, BucharestRomvac Company SA, BucharestThe study describes the development of a HPLC -DAD method for the estimation of oxytetracycline and furazolidone in Enteroguard M - powder. The proposed method utilizes a Betasil C 18 column, (4.6 x 250 mm, 5 µm), at 300 C, optimum mobile phase consisted of 40 mM phosphate buffer (pH=7.5): methanol in gradient elution. The flow rate was optimized to 1mL/min and the detection was carried at 254 nm. The drug substance was exposed to temperature, light, oxidants, acid and basic hydrolysis, and the resultant samples were analyzed by the proposed method.http://www.veterinarypharmacon.com/docs/1344-2014-VD-8-1-ART.8.EN.pdf |
| spellingShingle | Violeta Tauber (Giugiu), Viorica Chiurciu Forced degradation of metronidazole, oxytetracycline and furazolidone studies using High Performance Liquid Chromatography Medicamentul Veterinar |
| title | Forced degradation of metronidazole, oxytetracycline and furazolidone studies using High Performance Liquid Chromatography |
| title_full | Forced degradation of metronidazole, oxytetracycline and furazolidone studies using High Performance Liquid Chromatography |
| title_fullStr | Forced degradation of metronidazole, oxytetracycline and furazolidone studies using High Performance Liquid Chromatography |
| title_full_unstemmed | Forced degradation of metronidazole, oxytetracycline and furazolidone studies using High Performance Liquid Chromatography |
| title_short | Forced degradation of metronidazole, oxytetracycline and furazolidone studies using High Performance Liquid Chromatography |
| title_sort | forced degradation of metronidazole oxytetracycline and furazolidone studies using high performance liquid chromatography |
| url | http://www.veterinarypharmacon.com/docs/1344-2014-VD-8-1-ART.8.EN.pdf |
| work_keys_str_mv | AT violetataubergiugiu forceddegradationofmetronidazoleoxytetracyclineandfurazolidonestudiesusinghighperformanceliquidchromatography AT vioricachiurciu forceddegradationofmetronidazoleoxytetracyclineandfurazolidonestudiesusinghighperformanceliquidchromatography |