Redox Regulation and Glucose Metabolism in the Stallion Spermatozoa
Stallion spermatozoa are cells which exhibit intense metabolic activity, where oxidative phosphorylation in the mitochondria is the primary ATP generator. However, metabolism must be viewed as a highly interconnected network of oxidation–reduction reactions that generate the energy necessary for lif...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-02-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/14/2/225 |
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| author | Fernando J. Peña Francisco E. Martín-Cano Laura Becerro-Rey Eva da Silva-Álvarez Gemma Gaitskell-Phillips Inés M. Aparicio María C. Gil Cristina Ortega-Ferrusola |
| author_facet | Fernando J. Peña Francisco E. Martín-Cano Laura Becerro-Rey Eva da Silva-Álvarez Gemma Gaitskell-Phillips Inés M. Aparicio María C. Gil Cristina Ortega-Ferrusola |
| author_sort | Fernando J. Peña |
| collection | DOAJ |
| description | Stallion spermatozoa are cells which exhibit intense metabolic activity, where oxidative phosphorylation in the mitochondria is the primary ATP generator. However, metabolism must be viewed as a highly interconnected network of oxidation–reduction reactions that generate the energy necessary for life. An unavoidable side effect of metabolism is the generation of reactive oxygen species, leading to the evolution of sophisticated mechanisms to maintain redox homeostasis. In this paper, we provide an updated overview of glucose metabolism in stallion spermatozoa, highlighting recent evidence on the role of aerobic glycolysis in these cells, and the existence of an intracellular lactate shuttle that may help to explain the particular metabolism of the stallion spermatozoa in the context of their redox regulation. |
| format | Article |
| id | doaj-art-3a9bce21254c43c7adbfa80562eef5f1 |
| institution | DOAJ |
| issn | 2076-3921 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj-art-3a9bce21254c43c7adbfa80562eef5f12025-08-20T02:44:40ZengMDPI AGAntioxidants2076-39212025-02-0114222510.3390/antiox14020225Redox Regulation and Glucose Metabolism in the Stallion SpermatozoaFernando J. Peña0Francisco E. Martín-Cano1Laura Becerro-Rey2Eva da Silva-Álvarez3Gemma Gaitskell-Phillips4Inés M. Aparicio5María C. Gil6Cristina Ortega-Ferrusola7Laboratory of Equine Reproduction and Equine Spermatology, Veterinary Teaching Hospital, University of Extremadura, 10003 Cáceres, SpainLaboratory of Equine Reproduction and Equine Spermatology, Veterinary Teaching Hospital, University of Extremadura, 10003 Cáceres, SpainLaboratory of Equine Reproduction and Equine Spermatology, Veterinary Teaching Hospital, University of Extremadura, 10003 Cáceres, SpainLaboratory of Equine Reproduction and Equine Spermatology, Veterinary Teaching Hospital, University of Extremadura, 10003 Cáceres, SpainLaboratory of Equine Reproduction and Equine Spermatology, Veterinary Teaching Hospital, University of Extremadura, 10003 Cáceres, SpainLaboratory of Equine Reproduction and Equine Spermatology, Veterinary Teaching Hospital, University of Extremadura, 10003 Cáceres, SpainLaboratory of Equine Reproduction and Equine Spermatology, Veterinary Teaching Hospital, University of Extremadura, 10003 Cáceres, SpainLaboratory of Equine Reproduction and Equine Spermatology, Veterinary Teaching Hospital, University of Extremadura, 10003 Cáceres, SpainStallion spermatozoa are cells which exhibit intense metabolic activity, where oxidative phosphorylation in the mitochondria is the primary ATP generator. However, metabolism must be viewed as a highly interconnected network of oxidation–reduction reactions that generate the energy necessary for life. An unavoidable side effect of metabolism is the generation of reactive oxygen species, leading to the evolution of sophisticated mechanisms to maintain redox homeostasis. In this paper, we provide an updated overview of glucose metabolism in stallion spermatozoa, highlighting recent evidence on the role of aerobic glycolysis in these cells, and the existence of an intracellular lactate shuttle that may help to explain the particular metabolism of the stallion spermatozoa in the context of their redox regulation.https://www.mdpi.com/2076-3921/14/2/225stallionspermatozoaaerobic glycolysisROSmetabolism |
| spellingShingle | Fernando J. Peña Francisco E. Martín-Cano Laura Becerro-Rey Eva da Silva-Álvarez Gemma Gaitskell-Phillips Inés M. Aparicio María C. Gil Cristina Ortega-Ferrusola Redox Regulation and Glucose Metabolism in the Stallion Spermatozoa Antioxidants stallion spermatozoa aerobic glycolysis ROS metabolism |
| title | Redox Regulation and Glucose Metabolism in the Stallion Spermatozoa |
| title_full | Redox Regulation and Glucose Metabolism in the Stallion Spermatozoa |
| title_fullStr | Redox Regulation and Glucose Metabolism in the Stallion Spermatozoa |
| title_full_unstemmed | Redox Regulation and Glucose Metabolism in the Stallion Spermatozoa |
| title_short | Redox Regulation and Glucose Metabolism in the Stallion Spermatozoa |
| title_sort | redox regulation and glucose metabolism in the stallion spermatozoa |
| topic | stallion spermatozoa aerobic glycolysis ROS metabolism |
| url | https://www.mdpi.com/2076-3921/14/2/225 |
| work_keys_str_mv | AT fernandojpena redoxregulationandglucosemetabolisminthestallionspermatozoa AT franciscoemartincano redoxregulationandglucosemetabolisminthestallionspermatozoa AT laurabecerrorey redoxregulationandglucosemetabolisminthestallionspermatozoa AT evadasilvaalvarez redoxregulationandglucosemetabolisminthestallionspermatozoa AT gemmagaitskellphillips redoxregulationandglucosemetabolisminthestallionspermatozoa AT inesmaparicio redoxregulationandglucosemetabolisminthestallionspermatozoa AT mariacgil redoxregulationandglucosemetabolisminthestallionspermatozoa AT cristinaortegaferrusola redoxregulationandglucosemetabolisminthestallionspermatozoa |