Vocal brain development in infants of mothers with serious mental illness (CAPRI-Voc): study protocol
Introduction Improving the lives of children and adolescents with parental mental illness (CAPRI) remains an urgent political and public health concern for the UK and European Union. Recurrent parental mental illness is believed to lead to fractures in the family, academic and social lives of these...
Saved in:
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMJ Publishing Group
2022-03-01
|
| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/12/3/e053598.full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850281747472711680 |
|---|---|
| author | Kathryn M Abel Chen Zhao Rebecca Elliott Matthias Pierce Holly Hope Lucy Stibbs-Eaton Catherine Hodgson Adekeye Kolade Jennifer Crowell Jessica Gemignani Alya Elmadih Darragh Downey |
| author_facet | Kathryn M Abel Chen Zhao Rebecca Elliott Matthias Pierce Holly Hope Lucy Stibbs-Eaton Catherine Hodgson Adekeye Kolade Jennifer Crowell Jessica Gemignani Alya Elmadih Darragh Downey |
| author_sort | Kathryn M Abel |
| collection | DOAJ |
| description | Introduction Improving the lives of children and adolescents with parental mental illness (CAPRI) remains an urgent political and public health concern for the UK and European Union. Recurrent parental mental illness is believed to lead to fractures in the family, academic and social lives of these children, yet interventions are poorly targeted and non-specific. Part of an interdisciplinary programme of work (the CAPRI Programme; grant number: 682741), CAPRI-Voc aims to achieve two goals: first, to test the feasibility of our longitudinal imaging paradigm in mother–infant pairs where the mother has a diagnosis of severe mental illness. Second, to compare development of vocal processing in these infants with infants in the general population.Methods and analysis Recruitment of 100 infants of mothers with mental illness, alongside 50 infants of healthy mothers. Both cohorts of infants will undergo functional near infrared spectroscopy (fNIRS) brain imaging at three time points: 9, 12 and 18 months to explore differences between cohorts in their neural responses to vocal stimuli in our language paradigm. Mothers will complete an interview and psychological questionnaires. We shall also complete an infant developmental battery and mother–child interaction play session. Data on recruitment, retention and dropout will be recorded.Ethics and dissemination It will be made clear that fNIRS is a safe, non-invasive technology widely used in infant clinical and psychological research. We shall reassure mothers that no definitive causal link exists between maternal mental illness and language development in infants, and that individual data will only exist as part of the wider dataset. As the study includes both children and vulnerable adults, all research staff will complete National Health Service (NHS) Safeguarding level 3 training. Dissemination will be via direct feedback to stakeholders, patient and advisory groups, and through presentations at conferences, journal publications and university/NHS trust communications. The study was approved through North West–Greater Manchester West Research Ethics Committee (17/NW/0074) and Health Research Authority (212715). |
| format | Article |
| id | doaj-art-3a96ca5ffcea4876a2cdadd1ebd3917c |
| institution | OA Journals |
| issn | 2044-6055 |
| language | English |
| publishDate | 2022-03-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-3a96ca5ffcea4876a2cdadd1ebd3917c2025-08-20T01:48:11ZengBMJ Publishing GroupBMJ Open2044-60552022-03-0112310.1136/bmjopen-2021-053598Vocal brain development in infants of mothers with serious mental illness (CAPRI-Voc): study protocolKathryn M Abel0Chen Zhao1Rebecca Elliott2Matthias Pierce3Holly Hope4Lucy Stibbs-Eaton5Catherine Hodgson6Adekeye Kolade7Jennifer Crowell8Jessica Gemignani9Alya Elmadih10Darragh Downey11Greater Manchester Mental Health NHS Foundation Trust, Manchester, UKDepartment of Blood Purification, General Hospital of Northern Theatre Command, Shenyang, Liaoning, ChinaManchester University NHS Foundation Trust, NIHR Manchester BRC, Manchester Academic Health Science Centre, Manchester, United KingdomPsychology and Mental Health, The University of Manchester Faculty of Biology, Medicine and Health, Manchester, UKCentre for Women`s Mental Health, Faculty of Biology Medicine & Health, The University of Manchester, Manchester, UKPsychology and Mental Health, The University of Manchester Faculty of Biology, Medicine and Health, Manchester, UKPsychology and Mental Health, The University of Manchester Faculty of Biology, Medicine and Health, Manchester, UKPsychology and Mental Health, The University of Manchester Faculty of Biology, Medicine and Health, Manchester, UKPsychology and Mental Health, The University of Manchester Faculty of Biology, Medicine and Health, Manchester, UKDepartment of Developmental Psychology and Socialisation, University of Padua, Padova, ItalyPsychology and Mental Health, The University of Manchester Faculty of Biology, Medicine and Health, Manchester, UKDivision of Dentistry, The University of Manchester Faculty of Biology Medicine and Health, Manchester, UKIntroduction Improving the lives of children and adolescents with parental mental illness (CAPRI) remains an urgent political and public health concern for the UK and European Union. Recurrent parental mental illness is believed to lead to fractures in the family, academic and social lives of these children, yet interventions are poorly targeted and non-specific. Part of an interdisciplinary programme of work (the CAPRI Programme; grant number: 682741), CAPRI-Voc aims to achieve two goals: first, to test the feasibility of our longitudinal imaging paradigm in mother–infant pairs where the mother has a diagnosis of severe mental illness. Second, to compare development of vocal processing in these infants with infants in the general population.Methods and analysis Recruitment of 100 infants of mothers with mental illness, alongside 50 infants of healthy mothers. Both cohorts of infants will undergo functional near infrared spectroscopy (fNIRS) brain imaging at three time points: 9, 12 and 18 months to explore differences between cohorts in their neural responses to vocal stimuli in our language paradigm. Mothers will complete an interview and psychological questionnaires. We shall also complete an infant developmental battery and mother–child interaction play session. Data on recruitment, retention and dropout will be recorded.Ethics and dissemination It will be made clear that fNIRS is a safe, non-invasive technology widely used in infant clinical and psychological research. We shall reassure mothers that no definitive causal link exists between maternal mental illness and language development in infants, and that individual data will only exist as part of the wider dataset. As the study includes both children and vulnerable adults, all research staff will complete National Health Service (NHS) Safeguarding level 3 training. Dissemination will be via direct feedback to stakeholders, patient and advisory groups, and through presentations at conferences, journal publications and university/NHS trust communications. The study was approved through North West–Greater Manchester West Research Ethics Committee (17/NW/0074) and Health Research Authority (212715).https://bmjopen.bmj.com/content/12/3/e053598.full |
| spellingShingle | Kathryn M Abel Chen Zhao Rebecca Elliott Matthias Pierce Holly Hope Lucy Stibbs-Eaton Catherine Hodgson Adekeye Kolade Jennifer Crowell Jessica Gemignani Alya Elmadih Darragh Downey Vocal brain development in infants of mothers with serious mental illness (CAPRI-Voc): study protocol BMJ Open |
| title | Vocal brain development in infants of mothers with serious mental illness (CAPRI-Voc): study protocol |
| title_full | Vocal brain development in infants of mothers with serious mental illness (CAPRI-Voc): study protocol |
| title_fullStr | Vocal brain development in infants of mothers with serious mental illness (CAPRI-Voc): study protocol |
| title_full_unstemmed | Vocal brain development in infants of mothers with serious mental illness (CAPRI-Voc): study protocol |
| title_short | Vocal brain development in infants of mothers with serious mental illness (CAPRI-Voc): study protocol |
| title_sort | vocal brain development in infants of mothers with serious mental illness capri voc study protocol |
| url | https://bmjopen.bmj.com/content/12/3/e053598.full |
| work_keys_str_mv | AT kathrynmabel vocalbraindevelopmentininfantsofmotherswithseriousmentalillnesscaprivocstudyprotocol AT chenzhao vocalbraindevelopmentininfantsofmotherswithseriousmentalillnesscaprivocstudyprotocol AT rebeccaelliott vocalbraindevelopmentininfantsofmotherswithseriousmentalillnesscaprivocstudyprotocol AT matthiaspierce vocalbraindevelopmentininfantsofmotherswithseriousmentalillnesscaprivocstudyprotocol AT hollyhope vocalbraindevelopmentininfantsofmotherswithseriousmentalillnesscaprivocstudyprotocol AT lucystibbseaton vocalbraindevelopmentininfantsofmotherswithseriousmentalillnesscaprivocstudyprotocol AT catherinehodgson vocalbraindevelopmentininfantsofmotherswithseriousmentalillnesscaprivocstudyprotocol AT adekeyekolade vocalbraindevelopmentininfantsofmotherswithseriousmentalillnesscaprivocstudyprotocol AT jennifercrowell vocalbraindevelopmentininfantsofmotherswithseriousmentalillnesscaprivocstudyprotocol AT jessicagemignani vocalbraindevelopmentininfantsofmotherswithseriousmentalillnesscaprivocstudyprotocol AT alyaelmadih vocalbraindevelopmentininfantsofmotherswithseriousmentalillnesscaprivocstudyprotocol AT darraghdowney vocalbraindevelopmentininfantsofmotherswithseriousmentalillnesscaprivocstudyprotocol |