Epigenetic Changes Regulating Epithelial–Mesenchymal Plasticity in Human Trophoblast Differentiation

Epigenetic Changes Regulating Epithelial–Mesenchymal Plasticity in Human Trophoblast Differentiation

The phenotype of human placental extravillous trophoblast (EVT) at the end of pregnancy reflects both differentiation from villous cytotrophoblast (CTB) and later gestational changes, including loss of proliferative and invasive capacity. Invasion abnormalities are central to major obstetric patholo...

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Bibliographic Details
Main Authors: William E. Ackerman IV, Mauricio M. Rigo, Sonia C. DaSilva-Arnold, Catherine Do, Mariam Tariq, Martha Salas, Angelica Castano, Stacy Zamudio, Benjamin Tycko, Nicholas P. Illsley
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Cells
Subjects:
trophoblast
differentiation
epithelial–mesenchymal transition
DNA methylation
Online Access:https://www.mdpi.com/2073-4409/14/13/970
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