Candida Albicans Candidalysin ECE1 Gene − A Potent Virulence Factor for Oral Squamous Cell Carcinoma and Oral Potentially Malignant Disorders
Background: Candidalysin has been isolated initially from a pathogenic human fungus. The extent of cell elongation 1 (ECE1) gene codes for candidalysin of Candida albicans (C. albicans). This toxin is most important for epithelial immune activation, invasiveness and infection of the oral mucosa. Aim...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2024-11-01
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| Series: | Indian Journal of Dental Research |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/ijdr.ijdr_922_23 |
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| author | Mani B. Subramani Krishnan Mahalakshmi Bharathy Jaya Sankar Leena Sankari Venkatesan N. Kumar |
| author_facet | Mani B. Subramani Krishnan Mahalakshmi Bharathy Jaya Sankar Leena Sankari Venkatesan N. Kumar |
| author_sort | Mani B. Subramani |
| collection | DOAJ |
| description | Background:
Candidalysin has been isolated initially from a pathogenic human fungus. The extent of cell elongation 1 (ECE1) gene codes for candidalysin of Candida albicans (C. albicans). This toxin is most important for epithelial immune activation, invasiveness and infection of the oral mucosa.
Aim:
This study is aimed at detecting the ECE1 gene in C. albicans isolates from oral squamous cell carcinoma (OSCC) and oral potentially malignant disorders (OPMDs).
Methods and Material:
A total of 60 C. albicans isolates from OSCC (n = 23), OPMDs (n = 23) and healthy subjects (n = 14) were subjected to a polymerase chain reaction (PCR) for the detection of ECE1 gene. A high prevalence of the ECE1 gene was observed among the C. albicans isolates from OSCC and OPMD compared to the isolates from healthy subjects. Statistical significance was observed for both OSCC and OPMD groups compared to the healthy group.
Results and Conclusion:
The results suggest the significant role of candidalysin in oral oncogenesis. The high odds and risk ratio specify a strong association between candidalysin and these conditions. Screening this gene in a large number of isolates would further reinforce their role in oncogenesis. Future studies in characterizing their virulence on normal cell lines would clarify the importance of candidalysin in promoting oncogenesis. |
| format | Article |
| id | doaj-art-3a90af14f9d84bdeb455a127b9a826c4 |
| institution | Kabale University |
| issn | 0970-9290 1998-3603 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Dental Research |
| spelling | doaj-art-3a90af14f9d84bdeb455a127b9a826c42025-01-09T11:26:51ZengWolters Kluwer Medknow PublicationsIndian Journal of Dental Research0970-92901998-36032024-11-0135328128410.4103/ijdr.ijdr_922_23Candida Albicans Candidalysin ECE1 Gene − A Potent Virulence Factor for Oral Squamous Cell Carcinoma and Oral Potentially Malignant DisordersMani B. SubramaniKrishnan MahalakshmiBharathy JayaSankar Leena SankariVenkatesan N. KumarBackground: Candidalysin has been isolated initially from a pathogenic human fungus. The extent of cell elongation 1 (ECE1) gene codes for candidalysin of Candida albicans (C. albicans). This toxin is most important for epithelial immune activation, invasiveness and infection of the oral mucosa. Aim: This study is aimed at detecting the ECE1 gene in C. albicans isolates from oral squamous cell carcinoma (OSCC) and oral potentially malignant disorders (OPMDs). Methods and Material: A total of 60 C. albicans isolates from OSCC (n = 23), OPMDs (n = 23) and healthy subjects (n = 14) were subjected to a polymerase chain reaction (PCR) for the detection of ECE1 gene. A high prevalence of the ECE1 gene was observed among the C. albicans isolates from OSCC and OPMD compared to the isolates from healthy subjects. Statistical significance was observed for both OSCC and OPMD groups compared to the healthy group. Results and Conclusion: The results suggest the significant role of candidalysin in oral oncogenesis. The high odds and risk ratio specify a strong association between candidalysin and these conditions. Screening this gene in a large number of isolates would further reinforce their role in oncogenesis. Future studies in characterizing their virulence on normal cell lines would clarify the importance of candidalysin in promoting oncogenesis.https://journals.lww.com/10.4103/ijdr.ijdr_922_23candida albicanscandidalysinchain reactionoral potentially malignant disordersoral squamous cell carcinomapolymerase |
| spellingShingle | Mani B. Subramani Krishnan Mahalakshmi Bharathy Jaya Sankar Leena Sankari Venkatesan N. Kumar Candida Albicans Candidalysin ECE1 Gene − A Potent Virulence Factor for Oral Squamous Cell Carcinoma and Oral Potentially Malignant Disorders Indian Journal of Dental Research candida albicans candidalysin chain reaction oral potentially malignant disorders oral squamous cell carcinoma polymerase |
| title | Candida Albicans Candidalysin ECE1 Gene − A Potent Virulence Factor for Oral Squamous Cell Carcinoma and Oral Potentially Malignant Disorders |
| title_full | Candida Albicans Candidalysin ECE1 Gene − A Potent Virulence Factor for Oral Squamous Cell Carcinoma and Oral Potentially Malignant Disorders |
| title_fullStr | Candida Albicans Candidalysin ECE1 Gene − A Potent Virulence Factor for Oral Squamous Cell Carcinoma and Oral Potentially Malignant Disorders |
| title_full_unstemmed | Candida Albicans Candidalysin ECE1 Gene − A Potent Virulence Factor for Oral Squamous Cell Carcinoma and Oral Potentially Malignant Disorders |
| title_short | Candida Albicans Candidalysin ECE1 Gene − A Potent Virulence Factor for Oral Squamous Cell Carcinoma and Oral Potentially Malignant Disorders |
| title_sort | candida albicans candidalysin ece1 gene a potent virulence factor for oral squamous cell carcinoma and oral potentially malignant disorders |
| topic | candida albicans candidalysin chain reaction oral potentially malignant disorders oral squamous cell carcinoma polymerase |
| url | https://journals.lww.com/10.4103/ijdr.ijdr_922_23 |
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