TCF7L2 rs12255372 Gene Polymorphism and Susceptibility to Obesity: Experience from a Tertiary Level Hospital in Bangladesh
Introduction: The transcription factor 7-like 2 (TCF7L2) gene emerged as the most promising gene causing type 2 diabetes mellitus, which is associated with obesity. However, the genetic factors underlying obesity in the South Asian population remain largely unexplored. Objectives: This study aimed t...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2025-05-01
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| Series: | Indian Journal of Endocrinology and Metabolism |
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| Online Access: | https://journals.lww.com/10.4103/ijem.ijem_471_24 |
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| author | Syed A. Mahmood Mohammad F. Uddin Marufa Mustari Samira Mahjabeen Sarojit Das Md Kamrul Azad CFM Manzurur Rahim Samira Moyeen Shahjada Selim |
| author_facet | Syed A. Mahmood Mohammad F. Uddin Marufa Mustari Samira Mahjabeen Sarojit Das Md Kamrul Azad CFM Manzurur Rahim Samira Moyeen Shahjada Selim |
| author_sort | Syed A. Mahmood |
| collection | DOAJ |
| description | Introduction:
The transcription factor 7-like 2 (TCF7L2) gene emerged as the most promising gene causing type 2 diabetes mellitus, which is associated with obesity. However, the genetic factors underlying obesity in the South Asian population remain largely unexplored.
Objectives:
This study aimed to evaluate the relationship between the TCF7L2 gene polymorphism (rs12255372 G > T) and obesity, along with weight-related traits, in the Bangladeshi participants.
Methods:
This cross-sectional study was conducted in the Department of Endocrinology of a medical university. Eighty adults were enrolled by non-random sampling who met the inclusion and exclusion criteria and were categorized as obese and non-obese based on the WHO Expert Consultation 2004. The rs12255372 (G > T) polymorphism was genotyped using the polymerase chain reaction-restriction fragment length polymorphism technique, and statistical analysis was carried out using SPSS version 26.0 for Windows.
Results:
Out of 80 participants, 28 were obese and 52 non-obese. An allelic odds ratio (OR) of 3.86 (95% confidence interval (CI) 1.56–9.54; P = 0.002) was found for the minor T allele of TCF7L2 rs12255372 in obesity. A significant difference in GT genotype was observed between participants with obesity and without obesity (OR 3.53, 95% CI 1.13–11.07; P = 0.02).
Conclusion:
The minor T allele frequency of rs12255372 (G > T) among participants with obesity and without obesity were about 27% and 9%, respectively, indicating the rs12255372 (G > T) polymorphism of the TCF7L2 gene may be associated with the risk of obesity in the studied Bangladeshi population. |
| format | Article |
| id | doaj-art-3a8ea4819eca441d9f4ef2559ca48e55 |
| institution | DOAJ |
| issn | 2230-8210 2230-9500 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Endocrinology and Metabolism |
| spelling | doaj-art-3a8ea4819eca441d9f4ef2559ca48e552025-08-20T02:44:52ZengWolters Kluwer Medknow PublicationsIndian Journal of Endocrinology and Metabolism2230-82102230-95002025-05-0129331331810.4103/ijem.ijem_471_24TCF7L2 rs12255372 Gene Polymorphism and Susceptibility to Obesity: Experience from a Tertiary Level Hospital in BangladeshSyed A. MahmoodMohammad F. UddinMarufa MustariSamira MahjabeenSarojit DasMd Kamrul AzadCFM Manzurur RahimSamira MoyeenShahjada SelimIntroduction: The transcription factor 7-like 2 (TCF7L2) gene emerged as the most promising gene causing type 2 diabetes mellitus, which is associated with obesity. However, the genetic factors underlying obesity in the South Asian population remain largely unexplored. Objectives: This study aimed to evaluate the relationship between the TCF7L2 gene polymorphism (rs12255372 G > T) and obesity, along with weight-related traits, in the Bangladeshi participants. Methods: This cross-sectional study was conducted in the Department of Endocrinology of a medical university. Eighty adults were enrolled by non-random sampling who met the inclusion and exclusion criteria and were categorized as obese and non-obese based on the WHO Expert Consultation 2004. The rs12255372 (G > T) polymorphism was genotyped using the polymerase chain reaction-restriction fragment length polymorphism technique, and statistical analysis was carried out using SPSS version 26.0 for Windows. Results: Out of 80 participants, 28 were obese and 52 non-obese. An allelic odds ratio (OR) of 3.86 (95% confidence interval (CI) 1.56–9.54; P = 0.002) was found for the minor T allele of TCF7L2 rs12255372 in obesity. A significant difference in GT genotype was observed between participants with obesity and without obesity (OR 3.53, 95% CI 1.13–11.07; P = 0.02). Conclusion: The minor T allele frequency of rs12255372 (G > T) among participants with obesity and without obesity were about 27% and 9%, respectively, indicating the rs12255372 (G > T) polymorphism of the TCF7L2 gene may be associated with the risk of obesity in the studied Bangladeshi population.https://journals.lww.com/10.4103/ijem.ijem_471_24bangladeshgene mutationobesityrs12255372tcf7l2 |
| spellingShingle | Syed A. Mahmood Mohammad F. Uddin Marufa Mustari Samira Mahjabeen Sarojit Das Md Kamrul Azad CFM Manzurur Rahim Samira Moyeen Shahjada Selim TCF7L2 rs12255372 Gene Polymorphism and Susceptibility to Obesity: Experience from a Tertiary Level Hospital in Bangladesh Indian Journal of Endocrinology and Metabolism bangladesh gene mutation obesity rs12255372 tcf7l2 |
| title | TCF7L2 rs12255372 Gene Polymorphism and Susceptibility to Obesity: Experience from a Tertiary Level Hospital in Bangladesh |
| title_full | TCF7L2 rs12255372 Gene Polymorphism and Susceptibility to Obesity: Experience from a Tertiary Level Hospital in Bangladesh |
| title_fullStr | TCF7L2 rs12255372 Gene Polymorphism and Susceptibility to Obesity: Experience from a Tertiary Level Hospital in Bangladesh |
| title_full_unstemmed | TCF7L2 rs12255372 Gene Polymorphism and Susceptibility to Obesity: Experience from a Tertiary Level Hospital in Bangladesh |
| title_short | TCF7L2 rs12255372 Gene Polymorphism and Susceptibility to Obesity: Experience from a Tertiary Level Hospital in Bangladesh |
| title_sort | tcf7l2 rs12255372 gene polymorphism and susceptibility to obesity experience from a tertiary level hospital in bangladesh |
| topic | bangladesh gene mutation obesity rs12255372 tcf7l2 |
| url | https://journals.lww.com/10.4103/ijem.ijem_471_24 |
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