TCF7L2 rs12255372 Gene Polymorphism and Susceptibility to Obesity: Experience from a Tertiary Level Hospital in Bangladesh
Introduction: The transcription factor 7-like 2 (TCF7L2) gene emerged as the most promising gene causing type 2 diabetes mellitus, which is associated with obesity. However, the genetic factors underlying obesity in the South Asian population remain largely unexplored. Objectives: This study aimed t...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2025-05-01
|
| Series: | Indian Journal of Endocrinology and Metabolism |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/ijem.ijem_471_24 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | Introduction:
The transcription factor 7-like 2 (TCF7L2) gene emerged as the most promising gene causing type 2 diabetes mellitus, which is associated with obesity. However, the genetic factors underlying obesity in the South Asian population remain largely unexplored.
Objectives:
This study aimed to evaluate the relationship between the TCF7L2 gene polymorphism (rs12255372 G > T) and obesity, along with weight-related traits, in the Bangladeshi participants.
Methods:
This cross-sectional study was conducted in the Department of Endocrinology of a medical university. Eighty adults were enrolled by non-random sampling who met the inclusion and exclusion criteria and were categorized as obese and non-obese based on the WHO Expert Consultation 2004. The rs12255372 (G > T) polymorphism was genotyped using the polymerase chain reaction-restriction fragment length polymorphism technique, and statistical analysis was carried out using SPSS version 26.0 for Windows.
Results:
Out of 80 participants, 28 were obese and 52 non-obese. An allelic odds ratio (OR) of 3.86 (95% confidence interval (CI) 1.56–9.54; P = 0.002) was found for the minor T allele of TCF7L2 rs12255372 in obesity. A significant difference in GT genotype was observed between participants with obesity and without obesity (OR 3.53, 95% CI 1.13–11.07; P = 0.02).
Conclusion:
The minor T allele frequency of rs12255372 (G > T) among participants with obesity and without obesity were about 27% and 9%, respectively, indicating the rs12255372 (G > T) polymorphism of the TCF7L2 gene may be associated with the risk of obesity in the studied Bangladeshi population. |
|---|---|
| ISSN: | 2230-8210 2230-9500 |