Design, Synthesis and Characterization of Novel Arylamides Containing 1,2,4-triazole Nuclei for Possible Antimicrobial Activity
Diphenyl aceto hydrazide on reaction with carbon disulfide and potassium hydroxide gave potassium α,α-diphenyl acetamido dithiocarbamate, which on cyclisation with hydrazine hydrate yielded key intermediate 3-mercapto-4,N-amino-5-benzhydryl-1,2,4-triazoles. The key intermediate on condensation with...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2004-01-01
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| Series: | E-Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2004/240397 |
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| author | S. R. Dhol P. M. Gami R. C. Khunt A. R. Parikh |
| author_facet | S. R. Dhol P. M. Gami R. C. Khunt A. R. Parikh |
| author_sort | S. R. Dhol |
| collection | DOAJ |
| description | Diphenyl aceto hydrazide on reaction with carbon disulfide and potassium hydroxide gave potassium α,α-diphenyl acetamido dithiocarbamate, which on cyclisation with hydrazine hydrate yielded key intermediate 3-mercapto-4,N-amino-5-benzhydryl-1,2,4-triazoles. The key intermediate on condensation with different acid chloride afforded our titled compounds. The synthesised compounds have been confirmed elemental analyses and further supported by spectral data. All the synthesised compounds have been evaluated for their in vitroin vitro antimicrobial activity. |
| format | Article |
| id | doaj-art-3a8ac51bb42a4d90851a1ffbb1ce0064 |
| institution | Kabale University |
| issn | 0973-4945 2090-9810 |
| language | English |
| publishDate | 2004-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | E-Journal of Chemistry |
| spelling | doaj-art-3a8ac51bb42a4d90851a1ffbb1ce00642025-08-20T03:55:40ZengWileyE-Journal of Chemistry0973-49452090-98102004-01-011522823010.1155/2004/240397Design, Synthesis and Characterization of Novel Arylamides Containing 1,2,4-triazole Nuclei for Possible Antimicrobial ActivityS. R. Dhol0P. M. Gami1R. C. Khunt2A. R. Parikh3Chemistry Department, Saurashtra University, Rajkot-360 005, Gujarat, IndiaChemistry Department, Saurashtra University, Rajkot-360 005, Gujarat, IndiaChemistry Department, Saurashtra University, Rajkot-360 005, Gujarat, IndiaChemistry Department, Saurashtra University, Rajkot-360 005, Gujarat, IndiaDiphenyl aceto hydrazide on reaction with carbon disulfide and potassium hydroxide gave potassium α,α-diphenyl acetamido dithiocarbamate, which on cyclisation with hydrazine hydrate yielded key intermediate 3-mercapto-4,N-amino-5-benzhydryl-1,2,4-triazoles. The key intermediate on condensation with different acid chloride afforded our titled compounds. The synthesised compounds have been confirmed elemental analyses and further supported by spectral data. All the synthesised compounds have been evaluated for their in vitroin vitro antimicrobial activity.http://dx.doi.org/10.1155/2004/240397 |
| spellingShingle | S. R. Dhol P. M. Gami R. C. Khunt A. R. Parikh Design, Synthesis and Characterization of Novel Arylamides Containing 1,2,4-triazole Nuclei for Possible Antimicrobial Activity E-Journal of Chemistry |
| title | Design, Synthesis and Characterization of Novel Arylamides Containing 1,2,4-triazole Nuclei for Possible Antimicrobial Activity |
| title_full | Design, Synthesis and Characterization of Novel Arylamides Containing 1,2,4-triazole Nuclei for Possible Antimicrobial Activity |
| title_fullStr | Design, Synthesis and Characterization of Novel Arylamides Containing 1,2,4-triazole Nuclei for Possible Antimicrobial Activity |
| title_full_unstemmed | Design, Synthesis and Characterization of Novel Arylamides Containing 1,2,4-triazole Nuclei for Possible Antimicrobial Activity |
| title_short | Design, Synthesis and Characterization of Novel Arylamides Containing 1,2,4-triazole Nuclei for Possible Antimicrobial Activity |
| title_sort | design synthesis and characterization of novel arylamides containing 1 2 4 triazole nuclei for possible antimicrobial activity |
| url | http://dx.doi.org/10.1155/2004/240397 |
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