Therapeutic potential of calcitriol in cerebral ischemia/reperfusion injury: In vivo and in silico insights into TLR4 and FGFR2 pathways

Therapeutic potential of calcitriol in cerebral ischemia/reperfusion injury: In vivo and in silico insights into TLR4 and FGFR2 pathways

Background: Cerebral ischemic injury remains a major cause of high mortality, with limited effective treatments available. Inflammatory responses play a critical role in the pathophysiology of cerebral ischemia/reperfusion (I/R) injury. Suppressing inflammation is a key strategy for mitigating cereb...

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Bibliographic Details
Main Authors: Fahimeh Ramshini, Javad Amini Mahabadi, Reza Bayat, Sayyed Alireza Talaei, Zeinab Vahidinia, Hassan Hassani Bafrani
Format: Article
Language:English
Published: Elsevier 2025-12-01
Series:IBRO Neuroscience Reports
Subjects:
Calcitriol
Ischemic stroke
Neuroinflammation
NF-kβ
TLR4
MyD88
Online Access:http://www.sciencedirect.com/science/article/pii/S2667242125001149
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