Oxidative Stress and Inflammation: Essential Partners in Alcoholic Liver Disease
Alcoholic liver disease (ALD) is a multifaceted disease that is characterized by hepatic steatosis or fat deposition and hepatitis or inflammation. Over the past decade, multiple lines of evidence have emerged on the mechanisms associated with ALD. The key mechanisms identified so far are sensitizat...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
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| Series: | International Journal of Hepatology |
| Online Access: | http://dx.doi.org/10.1155/2012/853175 |
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| _version_ | 1850217544803155968 |
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| author | Aditya Ambade Pranoti Mandrekar |
| author_facet | Aditya Ambade Pranoti Mandrekar |
| author_sort | Aditya Ambade |
| collection | DOAJ |
| description | Alcoholic liver disease (ALD) is a multifaceted disease that is characterized by hepatic steatosis or fat deposition and hepatitis or inflammation. Over the past decade, multiple lines of evidence have emerged on the mechanisms associated with ALD. The key mechanisms identified so far are sensitization to gut-derived endotoxin/lipopolysaccharide resulting in proinflammatory cytokine production and cellular stress due to oxidative processes, contributing to the development and progression of disease. While oxidative stress and inflammatory responses are studied independently in ALD, mechanisms linking these two processes play a major role in pathogenesis of disease. Here we review major players of oxidative stress and inflammation and highlight signaling intermediates regulated by oxidative stress that provokes proinflammatory responses in alcoholic liver disease. |
| format | Article |
| id | doaj-art-3a8739689a0249e4aa992a44994d3368 |
| institution | OA Journals |
| issn | 2090-3448 2090-3456 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Hepatology |
| spelling | doaj-art-3a8739689a0249e4aa992a44994d33682025-08-20T02:08:02ZengWileyInternational Journal of Hepatology2090-34482090-34562012-01-01201210.1155/2012/853175853175Oxidative Stress and Inflammation: Essential Partners in Alcoholic Liver DiseaseAditya Ambade0Pranoti Mandrekar1Department of Medicine, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USADepartment of Medicine, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USAAlcoholic liver disease (ALD) is a multifaceted disease that is characterized by hepatic steatosis or fat deposition and hepatitis or inflammation. Over the past decade, multiple lines of evidence have emerged on the mechanisms associated with ALD. The key mechanisms identified so far are sensitization to gut-derived endotoxin/lipopolysaccharide resulting in proinflammatory cytokine production and cellular stress due to oxidative processes, contributing to the development and progression of disease. While oxidative stress and inflammatory responses are studied independently in ALD, mechanisms linking these two processes play a major role in pathogenesis of disease. Here we review major players of oxidative stress and inflammation and highlight signaling intermediates regulated by oxidative stress that provokes proinflammatory responses in alcoholic liver disease.http://dx.doi.org/10.1155/2012/853175 |
| spellingShingle | Aditya Ambade Pranoti Mandrekar Oxidative Stress and Inflammation: Essential Partners in Alcoholic Liver Disease International Journal of Hepatology |
| title | Oxidative Stress and Inflammation: Essential Partners in Alcoholic Liver Disease |
| title_full | Oxidative Stress and Inflammation: Essential Partners in Alcoholic Liver Disease |
| title_fullStr | Oxidative Stress and Inflammation: Essential Partners in Alcoholic Liver Disease |
| title_full_unstemmed | Oxidative Stress and Inflammation: Essential Partners in Alcoholic Liver Disease |
| title_short | Oxidative Stress and Inflammation: Essential Partners in Alcoholic Liver Disease |
| title_sort | oxidative stress and inflammation essential partners in alcoholic liver disease |
| url | http://dx.doi.org/10.1155/2012/853175 |
| work_keys_str_mv | AT adityaambade oxidativestressandinflammationessentialpartnersinalcoholicliverdisease AT pranotimandrekar oxidativestressandinflammationessentialpartnersinalcoholicliverdisease |