Transmembrane voltage-gated nanopores controlled by electrically tunable in-pore chemistry
Abstract Gating is a fundamental process in ion channels configured to open and close in response to specific stimuli such as voltage across cell membranes thereby enabling the excitability of neurons. Here we report on voltage-gated solid-state nanopores by electrically tunable chemical reactions....
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-02-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-025-56052-0 |
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| author | Makusu Tsutsui Wei-Lun Hsu Chien Hsu Denis Garoli Shukun Weng Hirofumi Daiguji Tomoji Kawai |
| author_facet | Makusu Tsutsui Wei-Lun Hsu Chien Hsu Denis Garoli Shukun Weng Hirofumi Daiguji Tomoji Kawai |
| author_sort | Makusu Tsutsui |
| collection | DOAJ |
| description | Abstract Gating is a fundamental process in ion channels configured to open and close in response to specific stimuli such as voltage across cell membranes thereby enabling the excitability of neurons. Here we report on voltage-gated solid-state nanopores by electrically tunable chemical reactions. We demonstrate repetitive precipitation and dissolution of metal phosphates in a pore through manipulations of cation flow by transmembrane voltage. Under negative voltages, precipitates grow to reduce ionic current by occluding the nanopore, while inverting the voltage polarity dissolves the phosphate compounds reopening the pore to ionic flux. Reversible actuation of these physicochemical processes creates a nanofluidic diode of rectification ratio exceeding 40000. The dynamic nature of the in-pore reactions also facilitates a memristor of sub-nanowatt power consumption. Leveraging chemical degrees of freedom, the present method may be useful for creating iontronic circuits of tunable characteristics toward neuromorphic systems. |
| format | Article |
| id | doaj-art-3a78084728d3442b93ee67851a229608 |
| institution | Kabale University |
| issn | 2041-1723 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-3a78084728d3442b93ee67851a2296082025-02-09T12:45:05ZengNature PortfolioNature Communications2041-17232025-02-0116111210.1038/s41467-025-56052-0Transmembrane voltage-gated nanopores controlled by electrically tunable in-pore chemistryMakusu Tsutsui0Wei-Lun Hsu1Chien Hsu2Denis Garoli3Shukun Weng4Hirofumi Daiguji5Tomoji Kawai6The Institute of Scientific and Industrial Research, Osaka UniversityDepartment of Mechanical Engineering, The University of TokyoDepartment of Mechanical Engineering, The University of TokyoIstituto Italiano di Tecnologia, Optoelectronics Research LineDipartimento di scienze e metodi dell’ingegneria, Università degli studi di modena e reggio emiliaDepartment of Mechanical Engineering, The University of TokyoThe Institute of Scientific and Industrial Research, Osaka UniversityAbstract Gating is a fundamental process in ion channels configured to open and close in response to specific stimuli such as voltage across cell membranes thereby enabling the excitability of neurons. Here we report on voltage-gated solid-state nanopores by electrically tunable chemical reactions. We demonstrate repetitive precipitation and dissolution of metal phosphates in a pore through manipulations of cation flow by transmembrane voltage. Under negative voltages, precipitates grow to reduce ionic current by occluding the nanopore, while inverting the voltage polarity dissolves the phosphate compounds reopening the pore to ionic flux. Reversible actuation of these physicochemical processes creates a nanofluidic diode of rectification ratio exceeding 40000. The dynamic nature of the in-pore reactions also facilitates a memristor of sub-nanowatt power consumption. Leveraging chemical degrees of freedom, the present method may be useful for creating iontronic circuits of tunable characteristics toward neuromorphic systems.https://doi.org/10.1038/s41467-025-56052-0 |
| spellingShingle | Makusu Tsutsui Wei-Lun Hsu Chien Hsu Denis Garoli Shukun Weng Hirofumi Daiguji Tomoji Kawai Transmembrane voltage-gated nanopores controlled by electrically tunable in-pore chemistry Nature Communications |
| title | Transmembrane voltage-gated nanopores controlled by electrically tunable in-pore chemistry |
| title_full | Transmembrane voltage-gated nanopores controlled by electrically tunable in-pore chemistry |
| title_fullStr | Transmembrane voltage-gated nanopores controlled by electrically tunable in-pore chemistry |
| title_full_unstemmed | Transmembrane voltage-gated nanopores controlled by electrically tunable in-pore chemistry |
| title_short | Transmembrane voltage-gated nanopores controlled by electrically tunable in-pore chemistry |
| title_sort | transmembrane voltage gated nanopores controlled by electrically tunable in pore chemistry |
| url | https://doi.org/10.1038/s41467-025-56052-0 |
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