Cardioprotective Properties Of Xenon
Abstract The review presents the main aspects of the cardioprotective properties of the xenon inhalation anesthetic. Based on the analysis of publications, the article discusses modern views on the mechanisms of the protective action of xenon, realized using pre- and post-conditioning mechanisms, sh...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | Russian |
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Sklifosovsky Research Institute for Emergency Medicine, Public Healthcare Institution of Moscow Healthcare Department
2020-10-01
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| Series: | Неотложная медицинская помощь |
| Subjects: | |
| Online Access: | https://www.jnmp.ru/jour/article/view/940 |
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| author | A. I. Shpichko O. A. Grebenchikov I. V. Molchanov A. K. Shabanov N. P. Shpichko K. K. Kadantseva |
| author_facet | A. I. Shpichko O. A. Grebenchikov I. V. Molchanov A. K. Shabanov N. P. Shpichko K. K. Kadantseva |
| author_sort | A. I. Shpichko |
| collection | DOAJ |
| description | Abstract The review presents the main aspects of the cardioprotective properties of the xenon inhalation anesthetic. Based on the analysis of publications, the article discusses modern views on the mechanisms of the protective action of xenon, realized using pre- and post-conditioning mechanisms, shows major molecular targets and their effects. The article presents the results of experimental studies in vivo and in vitro, which showed the protective effect of xenon on the myocardium and the results of recent randomized clinical trials. The analysis of studies demonstrates the ability of xenon to increase myocardial resistance to ischemia and reperfusion and opens up good prospects for its use in clinical practice in patients with a high risk of cardiac complications. |
| format | Article |
| id | doaj-art-3a76dc31bcec45b2b8e71f326757c3f0 |
| institution | Kabale University |
| issn | 2223-9022 2541-8017 |
| language | Russian |
| publishDate | 2020-10-01 |
| publisher | Sklifosovsky Research Institute for Emergency Medicine, Public Healthcare Institution of Moscow Healthcare Department |
| record_format | Article |
| series | Неотложная медицинская помощь |
| spelling | doaj-art-3a76dc31bcec45b2b8e71f326757c3f02025-08-20T03:56:37ZrusSklifosovsky Research Institute for Emergency Medicine, Public Healthcare Institution of Moscow Healthcare DepartmentНеотложная медицинская помощь2223-90222541-80172020-10-019226427210.23934/2223-9022-2020-9-2-264-272607Cardioprotective Properties Of XenonA. I. Shpichko0O. A. Grebenchikov1I. V. Molchanov2A. K. Shabanov3N. P. Shpichko4K. K. Kadantseva5Federal Scientific and Clinical Center for Resuscitation and RehabilitationFederal Scientific and Clinical Center for Resuscitation and RehabilitationFederal Scientific and Clinical Center for Resuscitation and RehabilitationFederal Scientific and Clinical Center for Resuscitation and Rehabilitation; N.V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow Health DepartmentFederal Scientific and Clinical Center for Resuscitation and RehabilitationFederal Scientific and Clinical Center for Resuscitation and RehabilitationAbstract The review presents the main aspects of the cardioprotective properties of the xenon inhalation anesthetic. Based on the analysis of publications, the article discusses modern views on the mechanisms of the protective action of xenon, realized using pre- and post-conditioning mechanisms, shows major molecular targets and their effects. The article presents the results of experimental studies in vivo and in vitro, which showed the protective effect of xenon on the myocardium and the results of recent randomized clinical trials. The analysis of studies demonstrates the ability of xenon to increase myocardial resistance to ischemia and reperfusion and opens up good prospects for its use in clinical practice in patients with a high risk of cardiac complications.https://www.jnmp.ru/jour/article/view/940xenoncardioprotectionischemia-myocardial reperfusioncardiac arrestnon-cardiac surgerycardiac surgery |
| spellingShingle | A. I. Shpichko O. A. Grebenchikov I. V. Molchanov A. K. Shabanov N. P. Shpichko K. K. Kadantseva Cardioprotective Properties Of Xenon Неотложная медицинская помощь xenon cardioprotection ischemia-myocardial reperfusion cardiac arrest non-cardiac surgery cardiac surgery |
| title | Cardioprotective Properties Of Xenon |
| title_full | Cardioprotective Properties Of Xenon |
| title_fullStr | Cardioprotective Properties Of Xenon |
| title_full_unstemmed | Cardioprotective Properties Of Xenon |
| title_short | Cardioprotective Properties Of Xenon |
| title_sort | cardioprotective properties of xenon |
| topic | xenon cardioprotection ischemia-myocardial reperfusion cardiac arrest non-cardiac surgery cardiac surgery |
| url | https://www.jnmp.ru/jour/article/view/940 |
| work_keys_str_mv | AT aishpichko cardioprotectivepropertiesofxenon AT oagrebenchikov cardioprotectivepropertiesofxenon AT ivmolchanov cardioprotectivepropertiesofxenon AT akshabanov cardioprotectivepropertiesofxenon AT npshpichko cardioprotectivepropertiesofxenon AT kkkadantseva cardioprotectivepropertiesofxenon |