Role of the Unfolded Protein Response in β Cell Compensation and Failure during Diabetes
Pancreatic β cell failure leads to diabetes development. During disease progression, β cells adapt their secretory capacity to compensate the elevated glycaemia and the peripheral insulin resistance. This compensatory mechanism involves a fine-tuned regulation to modulate the endoplasmic reticulum (...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2014/795171 |
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| author | Nabil Rabhi Elisabet Salas Philippe Froguel Jean-Sébastien Annicotte |
| author_facet | Nabil Rabhi Elisabet Salas Philippe Froguel Jean-Sébastien Annicotte |
| author_sort | Nabil Rabhi |
| collection | DOAJ |
| description | Pancreatic β cell failure leads to diabetes development. During disease progression, β cells adapt their secretory capacity to compensate the elevated glycaemia and the peripheral insulin resistance. This compensatory mechanism involves a fine-tuned regulation to modulate the endoplasmic reticulum (ER) capacity and quality control to prevent unfolded proinsulin accumulation, a major protein synthetized within the β cell. These signalling pathways are collectively termed unfolded protein response (UPR). The UPR machinery is required to preserve ER homeostasis and β cell integrity. Moreover, UPR actors play a key role by regulating ER folding capacity, increasing the degradation of misfolded proteins, and limiting the mRNA translation rate. Recent genetic and biochemical studies on mouse models and human UPR sensor mutations demonstrate a clear requirement of the UPR machinery to prevent β cell failure and increase β cell mass and adaptation throughout the progression of diabetes. In this review we will highlight the specific role of UPR actors in β cell compensation and failure during diabetes. |
| format | Article |
| id | doaj-art-3a6ee7047cb84b0ea1f0482f6cab38de |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-3a6ee7047cb84b0ea1f0482f6cab38de2025-08-20T03:35:51ZengWileyJournal of Diabetes Research2314-67452314-67532014-01-01201410.1155/2014/795171795171Role of the Unfolded Protein Response in β Cell Compensation and Failure during DiabetesNabil Rabhi0Elisabet Salas1Philippe Froguel2Jean-Sébastien Annicotte3European Genomic Institute for Diabetes (EGID), CNRS UMR 8199, Lille 2 University of Health and Law, 59000 Lille, FranceEuropean Genomic Institute for Diabetes (EGID), CNRS UMR 8199, Lille 2 University of Health and Law, 59000 Lille, FranceEuropean Genomic Institute for Diabetes (EGID), CNRS UMR 8199, Lille 2 University of Health and Law, 59000 Lille, FranceEuropean Genomic Institute for Diabetes (EGID), CNRS UMR 8199, Lille 2 University of Health and Law, 59000 Lille, FrancePancreatic β cell failure leads to diabetes development. During disease progression, β cells adapt their secretory capacity to compensate the elevated glycaemia and the peripheral insulin resistance. This compensatory mechanism involves a fine-tuned regulation to modulate the endoplasmic reticulum (ER) capacity and quality control to prevent unfolded proinsulin accumulation, a major protein synthetized within the β cell. These signalling pathways are collectively termed unfolded protein response (UPR). The UPR machinery is required to preserve ER homeostasis and β cell integrity. Moreover, UPR actors play a key role by regulating ER folding capacity, increasing the degradation of misfolded proteins, and limiting the mRNA translation rate. Recent genetic and biochemical studies on mouse models and human UPR sensor mutations demonstrate a clear requirement of the UPR machinery to prevent β cell failure and increase β cell mass and adaptation throughout the progression of diabetes. In this review we will highlight the specific role of UPR actors in β cell compensation and failure during diabetes.http://dx.doi.org/10.1155/2014/795171 |
| spellingShingle | Nabil Rabhi Elisabet Salas Philippe Froguel Jean-Sébastien Annicotte Role of the Unfolded Protein Response in β Cell Compensation and Failure during Diabetes Journal of Diabetes Research |
| title | Role of the Unfolded Protein Response in β Cell Compensation and Failure during Diabetes |
| title_full | Role of the Unfolded Protein Response in β Cell Compensation and Failure during Diabetes |
| title_fullStr | Role of the Unfolded Protein Response in β Cell Compensation and Failure during Diabetes |
| title_full_unstemmed | Role of the Unfolded Protein Response in β Cell Compensation and Failure during Diabetes |
| title_short | Role of the Unfolded Protein Response in β Cell Compensation and Failure during Diabetes |
| title_sort | role of the unfolded protein response in β cell compensation and failure during diabetes |
| url | http://dx.doi.org/10.1155/2014/795171 |
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