Preparation, Physical-Chemical Characterization, and Cytocompatibility of Polymeric Calcium Phosphate Cements
Aim. Physicochemical mechanical and in vitro biological properties of novel formulations of polymeric calcium phosphate cements (CPCs) were investigated. Methods. Monocalcium phosphate, calcium oxide, and synthetic hydroxyapatite were combined with either modified polyacrylic acid, light activated p...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | International Journal of Biomaterials |
| Online Access: | http://dx.doi.org/10.1155/2011/467641 |
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| _version_ | 1832566809362956288 |
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| author | Rania M. Khashaba Mervet Moussa Christopher Koch Arthur R. Jurgensen David M. Missimer Ronny L. Rutherford Norman B. Chutkan James L. Borke |
| author_facet | Rania M. Khashaba Mervet Moussa Christopher Koch Arthur R. Jurgensen David M. Missimer Ronny L. Rutherford Norman B. Chutkan James L. Borke |
| author_sort | Rania M. Khashaba |
| collection | DOAJ |
| description | Aim. Physicochemical mechanical and in vitro biological properties of novel formulations of polymeric calcium phosphate cements (CPCs) were investigated. Methods. Monocalcium phosphate, calcium oxide, and synthetic hydroxyapatite were combined with either modified polyacrylic acid, light activated polyalkenoic acid, or polymethyl vinyl ether maleic acid to obtain Types I, II, and III CPCs. Setting time, compressive and diametral strength of CPCs was compared with zinc polycarboxylate cement (control). Specimens were characterized using X-ray diffraction, scanning electron microscopy, and infrared spectroscopy. In vitro cytotoxicity of CPCs and control was assessed. Results. X-ray diffraction analysis showed hydroxyapatite, monetite, and brushite. Acid-base reaction was confirmed by the appearance of stretching peaks in IR spectra of set cements. SEM revealed rod-like crystals and platy crystals. Setting time of cements was 5–12 min. Type III showed significantly higher strength values compared to control. Type III yielded high biocompatibility. Conclusions. Type III CPCs show promise for dental applications. |
| format | Article |
| id | doaj-art-3a6e4f10a6d84611a67ee7c9c0d14639 |
| institution | Kabale University |
| issn | 1687-8787 1687-8795 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Biomaterials |
| spelling | doaj-art-3a6e4f10a6d84611a67ee7c9c0d146392025-02-03T01:02:59ZengWileyInternational Journal of Biomaterials1687-87871687-87952011-01-01201110.1155/2011/467641467641Preparation, Physical-Chemical Characterization, and Cytocompatibility of Polymeric Calcium Phosphate CementsRania M. Khashaba0Mervet Moussa1Christopher Koch2Arthur R. Jurgensen3David M. Missimer4Ronny L. Rutherford5Norman B. Chutkan6James L. Borke7Department Oral Biology, Medical College of Georgia, Augusta, GA 30912-1129, USADepartment of Oral Pathology, Cairo University, Cairo 11559, EgyptDepartment Orthopaedic Surgery, Section of Biomaterials, Medical College of Georgia, Augusta, GA 30912-1129, USASavannah River National Laboratory, Savannah River Nuclear Solutions, Aiken, SC 29808, USASavannah River National Laboratory, Savannah River Nuclear Solutions, Aiken, SC 29808, USASavannah River National Laboratory, Savannah River Nuclear Solutions, Aiken, SC 29808, USADepartment Orthopaedic Surgery, Section of Biomaterials, Medical College of Georgia, Augusta, GA 30912-1129, USADepartment Oral Biology, Medical College of Georgia, Augusta, GA 30912-1129, USAAim. Physicochemical mechanical and in vitro biological properties of novel formulations of polymeric calcium phosphate cements (CPCs) were investigated. Methods. Monocalcium phosphate, calcium oxide, and synthetic hydroxyapatite were combined with either modified polyacrylic acid, light activated polyalkenoic acid, or polymethyl vinyl ether maleic acid to obtain Types I, II, and III CPCs. Setting time, compressive and diametral strength of CPCs was compared with zinc polycarboxylate cement (control). Specimens were characterized using X-ray diffraction, scanning electron microscopy, and infrared spectroscopy. In vitro cytotoxicity of CPCs and control was assessed. Results. X-ray diffraction analysis showed hydroxyapatite, monetite, and brushite. Acid-base reaction was confirmed by the appearance of stretching peaks in IR spectra of set cements. SEM revealed rod-like crystals and platy crystals. Setting time of cements was 5–12 min. Type III showed significantly higher strength values compared to control. Type III yielded high biocompatibility. Conclusions. Type III CPCs show promise for dental applications.http://dx.doi.org/10.1155/2011/467641 |
| spellingShingle | Rania M. Khashaba Mervet Moussa Christopher Koch Arthur R. Jurgensen David M. Missimer Ronny L. Rutherford Norman B. Chutkan James L. Borke Preparation, Physical-Chemical Characterization, and Cytocompatibility of Polymeric Calcium Phosphate Cements International Journal of Biomaterials |
| title | Preparation, Physical-Chemical Characterization, and Cytocompatibility of Polymeric Calcium Phosphate Cements |
| title_full | Preparation, Physical-Chemical Characterization, and Cytocompatibility of Polymeric Calcium Phosphate Cements |
| title_fullStr | Preparation, Physical-Chemical Characterization, and Cytocompatibility of Polymeric Calcium Phosphate Cements |
| title_full_unstemmed | Preparation, Physical-Chemical Characterization, and Cytocompatibility of Polymeric Calcium Phosphate Cements |
| title_short | Preparation, Physical-Chemical Characterization, and Cytocompatibility of Polymeric Calcium Phosphate Cements |
| title_sort | preparation physical chemical characterization and cytocompatibility of polymeric calcium phosphate cements |
| url | http://dx.doi.org/10.1155/2011/467641 |
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