Molecular pathogenesis of Cryptosporidium and advancements in therapeutic interventions
Cryptosporidiosis, caused by a Cryptosporidium infection, is a serious gastrointestinal disease commonly leading to diarrhea in humans. This disease poses a particular threat to infants, young children, and those with weakened immune systems. The treatment of cryptosporidiosis is challenging due to...
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EDP Sciences
2025-01-01
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| Series: | Parasite |
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| Online Access: | https://www.parasite-journal.org/articles/parasite/full_html/2025/01/parasite240139/parasite240139.html |
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| _version_ | 1825206554296582144 |
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| author | Lu Yilong Zhang Xiaoning Guan Zhiyu Ji Rui Peng Fujun Zhao Chunzhen Gao Wei Gao Feng |
| author_facet | Lu Yilong Zhang Xiaoning Guan Zhiyu Ji Rui Peng Fujun Zhao Chunzhen Gao Wei Gao Feng |
| author_sort | Lu Yilong |
| collection | DOAJ |
| description | Cryptosporidiosis, caused by a Cryptosporidium infection, is a serious gastrointestinal disease commonly leading to diarrhea in humans. This disease poses a particular threat to infants, young children, and those with weakened immune systems. The treatment of cryptosporidiosis is challenging due to the current lack of an effective treatment or vaccine. Ongoing research is focused on understanding the molecular pathogenesis of Cryptosporidium and developing pharmacological treatments. In this review, we examine the signaling pathways activated by Cryptosporidium infection within the host and their role in protecting host epithelial cells. Additionally, we also review the research progress of chemotherapeutic targets against cryptosporidia-specific enzymes and anti-Cryptosporidium drugs (including Chinese and Western medicinal drugs), aiming at the development of more effective treatments for cryptosporidiosis. |
| format | Article |
| id | doaj-art-3a68a28f460346e2bf20ad3827b61ce5 |
| institution | Kabale University |
| issn | 1776-1042 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | EDP Sciences |
| record_format | Article |
| series | Parasite |
| spelling | doaj-art-3a68a28f460346e2bf20ad3827b61ce52025-02-07T08:27:16ZengEDP SciencesParasite1776-10422025-01-0132710.1051/parasite/2025001parasite240139Molecular pathogenesis of Cryptosporidium and advancements in therapeutic interventionsLu Yilong0Zhang Xiaoning1Guan Zhiyu2Ji Rui3https://orcid.org/0009-0008-8875-6588Peng Fujun4Zhao Chunzhen5Gao Wei6Gao Feng7College of Basic Medical Sciences, Shandong Second Medical UniversityCollege of Basic Medical Sciences, Shandong Second Medical UniversityCollege of Basic Medical Sciences, Shandong Second Medical UniversityCollege of Traditional Chinese Medicine, Shandong Second Medical UniversityCollege of Basic Medical Sciences, Shandong Second Medical UniversityCollege of Pharmacy, Shandong Second Medical UniversityCollege of Clinical Medicine, Shandong Second Medical UniversityCollege of Pharmacy, Shandong Second Medical UniversityCryptosporidiosis, caused by a Cryptosporidium infection, is a serious gastrointestinal disease commonly leading to diarrhea in humans. This disease poses a particular threat to infants, young children, and those with weakened immune systems. The treatment of cryptosporidiosis is challenging due to the current lack of an effective treatment or vaccine. Ongoing research is focused on understanding the molecular pathogenesis of Cryptosporidium and developing pharmacological treatments. In this review, we examine the signaling pathways activated by Cryptosporidium infection within the host and their role in protecting host epithelial cells. Additionally, we also review the research progress of chemotherapeutic targets against cryptosporidia-specific enzymes and anti-Cryptosporidium drugs (including Chinese and Western medicinal drugs), aiming at the development of more effective treatments for cryptosporidiosis.https://www.parasite-journal.org/articles/parasite/full_html/2025/01/parasite240139/parasite240139.htmlcryptosporidiumcryptosporidiosissignaling pathwaysenzymatic targetsdrug therapy |
| spellingShingle | Lu Yilong Zhang Xiaoning Guan Zhiyu Ji Rui Peng Fujun Zhao Chunzhen Gao Wei Gao Feng Molecular pathogenesis of Cryptosporidium and advancements in therapeutic interventions Parasite cryptosporidium cryptosporidiosis signaling pathways enzymatic targets drug therapy |
| title | Molecular pathogenesis of Cryptosporidium and advancements in therapeutic interventions |
| title_full | Molecular pathogenesis of Cryptosporidium and advancements in therapeutic interventions |
| title_fullStr | Molecular pathogenesis of Cryptosporidium and advancements in therapeutic interventions |
| title_full_unstemmed | Molecular pathogenesis of Cryptosporidium and advancements in therapeutic interventions |
| title_short | Molecular pathogenesis of Cryptosporidium and advancements in therapeutic interventions |
| title_sort | molecular pathogenesis of cryptosporidium and advancements in therapeutic interventions |
| topic | cryptosporidium cryptosporidiosis signaling pathways enzymatic targets drug therapy |
| url | https://www.parasite-journal.org/articles/parasite/full_html/2025/01/parasite240139/parasite240139.html |
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