Strategies Used for the Discovery of New Microbial Metabolites with Antibiotic Activity
The discovery of new microbial metabolites is essential to combat the alarming rise in antimicrobial resistance and to meet emerging medical needs. This work critically reviews current strategies for identifying antimicrobial compounds, emphasizing the potential of microorganisms as a rich source of...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-07-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/30/13/2868 |
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| author | Pablo Dasí-Delgado Cecilia Andreu Marcel·lí del Olmo |
| author_facet | Pablo Dasí-Delgado Cecilia Andreu Marcel·lí del Olmo |
| author_sort | Pablo Dasí-Delgado |
| collection | DOAJ |
| description | The discovery of new microbial metabolites is essential to combat the alarming rise in antimicrobial resistance and to meet emerging medical needs. This work critically reviews current strategies for identifying antimicrobial compounds, emphasizing the potential of microorganisms as a rich source of bioactive secondary metabolites. This review explores innovative methods, such as investigating extreme environments where adverse conditions favor the emergence of unique metabolites; developing techniques, like the iChip, to cultivate previously uncultivable bacteria; using metagenomics to analyze complex samples that are difficult to isolate; and integrates artificial intelligence to accelerate genomic mining, structural prediction, and drug discovery optimization processes. The importance of overcoming current challenges, such as replicating findings, low research investment, and the lack of adapted collection technologies, is also emphasized. Additionally, this work analyzes the crucial role of bacterial resistance and the necessity of a holistic approach involving new technologies, sustained investment, and interdisciplinary collaboration. This work emphasizes not only the current state of metabolite discovery but also the challenges that must be addressed to ensure a continuous flow of new therapeutic molecules in the coming decades. |
| format | Article |
| id | doaj-art-3a66dc7fc61646cb9ee9fdc6f521613e |
| institution | Kabale University |
| issn | 1420-3049 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj-art-3a66dc7fc61646cb9ee9fdc6f521613e2025-08-20T03:50:16ZengMDPI AGMolecules1420-30492025-07-013013286810.3390/molecules30132868Strategies Used for the Discovery of New Microbial Metabolites with Antibiotic ActivityPablo Dasí-Delgado0Cecilia Andreu1Marcel·lí del Olmo2Departament de Bioquímica i Biologia Molecular, Universitat de València (UVEG), Dr. Moliner 50, E-46100 Burjassot, València, SpainDepartament de Química Orgànica, Universitat de València (UVEG), Vicent Andrés Estellés s.n., E-46100 Burjassot, València, SpainDepartament de Bioquímica i Biologia Molecular, Universitat de València (UVEG), Dr. Moliner 50, E-46100 Burjassot, València, SpainThe discovery of new microbial metabolites is essential to combat the alarming rise in antimicrobial resistance and to meet emerging medical needs. This work critically reviews current strategies for identifying antimicrobial compounds, emphasizing the potential of microorganisms as a rich source of bioactive secondary metabolites. This review explores innovative methods, such as investigating extreme environments where adverse conditions favor the emergence of unique metabolites; developing techniques, like the iChip, to cultivate previously uncultivable bacteria; using metagenomics to analyze complex samples that are difficult to isolate; and integrates artificial intelligence to accelerate genomic mining, structural prediction, and drug discovery optimization processes. The importance of overcoming current challenges, such as replicating findings, low research investment, and the lack of adapted collection technologies, is also emphasized. Additionally, this work analyzes the crucial role of bacterial resistance and the necessity of a holistic approach involving new technologies, sustained investment, and interdisciplinary collaboration. This work emphasizes not only the current state of metabolite discovery but also the challenges that must be addressed to ensure a continuous flow of new therapeutic molecules in the coming decades.https://www.mdpi.com/1420-3049/30/13/2868antibioticantimicrobial resistanceartificial intelligencedrug discoveryextremophilesisolation Chip |
| spellingShingle | Pablo Dasí-Delgado Cecilia Andreu Marcel·lí del Olmo Strategies Used for the Discovery of New Microbial Metabolites with Antibiotic Activity Molecules antibiotic antimicrobial resistance artificial intelligence drug discovery extremophiles isolation Chip |
| title | Strategies Used for the Discovery of New Microbial Metabolites with Antibiotic Activity |
| title_full | Strategies Used for the Discovery of New Microbial Metabolites with Antibiotic Activity |
| title_fullStr | Strategies Used for the Discovery of New Microbial Metabolites with Antibiotic Activity |
| title_full_unstemmed | Strategies Used for the Discovery of New Microbial Metabolites with Antibiotic Activity |
| title_short | Strategies Used for the Discovery of New Microbial Metabolites with Antibiotic Activity |
| title_sort | strategies used for the discovery of new microbial metabolites with antibiotic activity |
| topic | antibiotic antimicrobial resistance artificial intelligence drug discovery extremophiles isolation Chip |
| url | https://www.mdpi.com/1420-3049/30/13/2868 |
| work_keys_str_mv | AT pablodasidelgado strategiesusedforthediscoveryofnewmicrobialmetaboliteswithantibioticactivity AT ceciliaandreu strategiesusedforthediscoveryofnewmicrobialmetaboliteswithantibioticactivity AT marcellidelolmo strategiesusedforthediscoveryofnewmicrobialmetaboliteswithantibioticactivity |