Overview of the Surgical Management of Liver Oligometastatic Disease in Colorectal Cancer
Oligometastatic colorectal cancer (CRC) refers to a state in which distant metastatic spread is limited to a few sites, offering the potential for curative treatment with aggressive local therapies. The surgical management of oligometastatic CRC has gained increasing attention due to its potential t...
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MDPI AG
2025-05-01
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| Series: | Journal of Mind and Medical Sciences |
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| Online Access: | https://www.mdpi.com/2392-7674/12/1/31 |
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| author | Anca Monica Oprescu Macovei Dana Paula Venter Bogdan Dumitriu Constantin Oprescu Mircea Dan Venter Gabriel-Nicolae Andrei Mures Sebastian Valcea Precup Bogdan Socea Mihai Stefan |
| author_facet | Anca Monica Oprescu Macovei Dana Paula Venter Bogdan Dumitriu Constantin Oprescu Mircea Dan Venter Gabriel-Nicolae Andrei Mures Sebastian Valcea Precup Bogdan Socea Mihai Stefan |
| author_sort | Anca Monica Oprescu Macovei |
| collection | DOAJ |
| description | Oligometastatic colorectal cancer (CRC) refers to a state in which distant metastatic spread is limited to a few sites, offering the potential for curative treatment with aggressive local therapies. The surgical management of oligometastatic CRC has gained increasing attention due to its potential to improve survival. This review explores the evolving role of surgery in the treatment of oligometastatic disease, focusing on the criteria for selecting patients, surgical techniques, and outcomes. While systemic therapy remains essential, surgery can offer long-term survival benefits for appropriately selected patients with limited metastatic disease, particularly those with metastases confined to the liver. Advances in imaging technologies, minimally invasive surgical techniques, and perioperative care have enhanced the safety and efficacy of these procedures. The integration of multimodal therapies, such as chemotherapy, targeted therapy, and immunotherapy, in conjunction with surgery, is also discussed, with a focus on optimizing outcomes. To conclude, surgical resection of liver metastases improves survival compared to systemic therapy alone; thus, resection should be taken into consideration whenever possible. For initially unresectable diseases, personalized conversion therapy is indicated. This review aims to clarify how and when liver resection can first be chosen; when preoperative systemic treatment is needed; and if this is chosen, what is the best approach. |
| format | Article |
| id | doaj-art-3a668fd6b608406ca656d63ebf93a51c |
| institution | DOAJ |
| issn | 2392-7674 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Mind and Medical Sciences |
| spelling | doaj-art-3a668fd6b608406ca656d63ebf93a51c2025-08-20T03:16:32ZengMDPI AGJournal of Mind and Medical Sciences2392-76742025-05-011213110.3390/jmms12010031Overview of the Surgical Management of Liver Oligometastatic Disease in Colorectal CancerAnca Monica Oprescu Macovei0Dana Paula Venter1Bogdan Dumitriu2Constantin Oprescu3Mircea Dan Venter4Gabriel-Nicolae Andrei5Mures Sebastian Valcea Precup6Bogdan Socea7Mihai Stefan8Department of Gastroenterology, Agrippa Ionescu Emergency Clinical Hospital, 011356 Bucharest, RomaniaDepartment of Pediatric Surgery, Grigore Alexandrescu Hospital, 014461 Bucharest, RomaniaDepartment of General Surgery, Floreasca Hospital, 014461 Bucharest, RomaniaDepartment of General Surgery, Floreasca Hospital, 014461 Bucharest, RomaniaDepartment of General Surgery, Floreasca Hospital, 014461 Bucharest, RomaniaDepartment of General Surgery, Floreasca Hospital, 014461 Bucharest, RomaniaDepartment of General Surgery, Floreasca Hospital, 014461 Bucharest, RomaniaDepartment of General Surgery, Pantelimon Hospital, 021659 Bucharest, RomaniaDepartment of General Surgery, Floreasca Hospital, 014461 Bucharest, RomaniaOligometastatic colorectal cancer (CRC) refers to a state in which distant metastatic spread is limited to a few sites, offering the potential for curative treatment with aggressive local therapies. The surgical management of oligometastatic CRC has gained increasing attention due to its potential to improve survival. This review explores the evolving role of surgery in the treatment of oligometastatic disease, focusing on the criteria for selecting patients, surgical techniques, and outcomes. While systemic therapy remains essential, surgery can offer long-term survival benefits for appropriately selected patients with limited metastatic disease, particularly those with metastases confined to the liver. Advances in imaging technologies, minimally invasive surgical techniques, and perioperative care have enhanced the safety and efficacy of these procedures. The integration of multimodal therapies, such as chemotherapy, targeted therapy, and immunotherapy, in conjunction with surgery, is also discussed, with a focus on optimizing outcomes. To conclude, surgical resection of liver metastases improves survival compared to systemic therapy alone; thus, resection should be taken into consideration whenever possible. For initially unresectable diseases, personalized conversion therapy is indicated. This review aims to clarify how and when liver resection can first be chosen; when preoperative systemic treatment is needed; and if this is chosen, what is the best approach.https://www.mdpi.com/2392-7674/12/1/31colorectal cancermCRColigometastatichepatic metastases |
| spellingShingle | Anca Monica Oprescu Macovei Dana Paula Venter Bogdan Dumitriu Constantin Oprescu Mircea Dan Venter Gabriel-Nicolae Andrei Mures Sebastian Valcea Precup Bogdan Socea Mihai Stefan Overview of the Surgical Management of Liver Oligometastatic Disease in Colorectal Cancer Journal of Mind and Medical Sciences colorectal cancer mCRC oligometastatic hepatic metastases |
| title | Overview of the Surgical Management of Liver Oligometastatic Disease in Colorectal Cancer |
| title_full | Overview of the Surgical Management of Liver Oligometastatic Disease in Colorectal Cancer |
| title_fullStr | Overview of the Surgical Management of Liver Oligometastatic Disease in Colorectal Cancer |
| title_full_unstemmed | Overview of the Surgical Management of Liver Oligometastatic Disease in Colorectal Cancer |
| title_short | Overview of the Surgical Management of Liver Oligometastatic Disease in Colorectal Cancer |
| title_sort | overview of the surgical management of liver oligometastatic disease in colorectal cancer |
| topic | colorectal cancer mCRC oligometastatic hepatic metastases |
| url | https://www.mdpi.com/2392-7674/12/1/31 |
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