Functional modularity of nuclear hormone receptors in a Caenorhabditis elegans metabolic gene regulatory network
Abstract Gene regulatory networks (GRNs) provide insights into the mechanisms of differential gene expression at a systems level. GRNs that relate to metazoan development have been studied extensively. However, little is still known about the design principles, organization and functionality of GRNs...
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| Format: | Article |
| Language: | English |
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Springer Nature
2010-05-01
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| Series: | Molecular Systems Biology |
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| Online Access: | https://doi.org/10.1038/msb.2010.23 |
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| _version_ | 1849225755297316864 |
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| author | H Efsun Arda Stefan Taubert Lesley T MacNeil Colin C Conine Ben Tsuda Marc Van Gilst Reynaldo Sequerra Lynn Doucette‐Stamm Keith R Yamamoto Albertha J M Walhout |
| author_facet | H Efsun Arda Stefan Taubert Lesley T MacNeil Colin C Conine Ben Tsuda Marc Van Gilst Reynaldo Sequerra Lynn Doucette‐Stamm Keith R Yamamoto Albertha J M Walhout |
| author_sort | H Efsun Arda |
| collection | DOAJ |
| description | Abstract Gene regulatory networks (GRNs) provide insights into the mechanisms of differential gene expression at a systems level. GRNs that relate to metazoan development have been studied extensively. However, little is still known about the design principles, organization and functionality of GRNs that control physiological processes such as metabolism, homeostasis and responses to environmental cues. In this study, we report the first experimentally mapped metazoan GRN of Caenorhabditis elegans metabolic genes. This network is enriched for nuclear hormone receptors (NHRs). The NHR family has greatly expanded in nematodes: humans have 48 NHRs, but C. elegans has 284, most of which are uncharacterized. We find that the C. elegans metabolic GRN is highly modular and that two GRN modules predominantly consist of NHRs. Network modularity has been proposed to facilitate a rapid response to different cues. As NHRs are metabolic sensors that are poised to respond to ligands, this suggests that C. elegans GRNs evolved to enable rapid and adaptive responses to different cues by a concurrence of NHR family expansion and modular GRN wiring. |
| format | Article |
| id | doaj-art-3a65b7317a6a45a985811f7268e68db3 |
| institution | Kabale University |
| issn | 1744-4292 |
| language | English |
| publishDate | 2010-05-01 |
| publisher | Springer Nature |
| record_format | Article |
| series | Molecular Systems Biology |
| spelling | doaj-art-3a65b7317a6a45a985811f7268e68db32025-08-24T12:00:42ZengSpringer NatureMolecular Systems Biology1744-42922010-05-016111410.1038/msb.2010.23Functional modularity of nuclear hormone receptors in a Caenorhabditis elegans metabolic gene regulatory networkH Efsun Arda0Stefan Taubert1Lesley T MacNeil2Colin C Conine3Ben Tsuda4Marc Van Gilst5Reynaldo Sequerra6Lynn Doucette‐Stamm7Keith R Yamamoto8Albertha J M Walhout9Program in Gene Function and Expression and Program in Molecular Medicine, University of Massachusetts Medical SchoolDepartment of Cellular and Molecular Pharmacology, University of CaliforniaProgram in Gene Function and Expression and Program in Molecular Medicine, University of Massachusetts Medical SchoolProgram in Gene Function and Expression and Program in Molecular Medicine, University of Massachusetts Medical SchoolProgram in Gene Function and Expression and Program in Molecular Medicine, University of Massachusetts Medical SchoolBasic Sciences Division, Fred Hutchinson Cancer Research CenterAgencourt Bioscience CorporationAgencourt Bioscience CorporationDepartment of Cellular and Molecular Pharmacology, University of CaliforniaProgram in Gene Function and Expression and Program in Molecular Medicine, University of Massachusetts Medical SchoolAbstract Gene regulatory networks (GRNs) provide insights into the mechanisms of differential gene expression at a systems level. GRNs that relate to metazoan development have been studied extensively. However, little is still known about the design principles, organization and functionality of GRNs that control physiological processes such as metabolism, homeostasis and responses to environmental cues. In this study, we report the first experimentally mapped metazoan GRN of Caenorhabditis elegans metabolic genes. This network is enriched for nuclear hormone receptors (NHRs). The NHR family has greatly expanded in nematodes: humans have 48 NHRs, but C. elegans has 284, most of which are uncharacterized. We find that the C. elegans metabolic GRN is highly modular and that two GRN modules predominantly consist of NHRs. Network modularity has been proposed to facilitate a rapid response to different cues. As NHRs are metabolic sensors that are poised to respond to ligands, this suggests that C. elegans GRNs evolved to enable rapid and adaptive responses to different cues by a concurrence of NHR family expansion and modular GRN wiring.https://doi.org/10.1038/msb.2010.23C. elegansgene regulatory networkmetabolismnuclear hormone receptortranscription factor |
| spellingShingle | H Efsun Arda Stefan Taubert Lesley T MacNeil Colin C Conine Ben Tsuda Marc Van Gilst Reynaldo Sequerra Lynn Doucette‐Stamm Keith R Yamamoto Albertha J M Walhout Functional modularity of nuclear hormone receptors in a Caenorhabditis elegans metabolic gene regulatory network Molecular Systems Biology C. elegans gene regulatory network metabolism nuclear hormone receptor transcription factor |
| title | Functional modularity of nuclear hormone receptors in a Caenorhabditis elegans metabolic gene regulatory network |
| title_full | Functional modularity of nuclear hormone receptors in a Caenorhabditis elegans metabolic gene regulatory network |
| title_fullStr | Functional modularity of nuclear hormone receptors in a Caenorhabditis elegans metabolic gene regulatory network |
| title_full_unstemmed | Functional modularity of nuclear hormone receptors in a Caenorhabditis elegans metabolic gene regulatory network |
| title_short | Functional modularity of nuclear hormone receptors in a Caenorhabditis elegans metabolic gene regulatory network |
| title_sort | functional modularity of nuclear hormone receptors in a caenorhabditis elegans metabolic gene regulatory network |
| topic | C. elegans gene regulatory network metabolism nuclear hormone receptor transcription factor |
| url | https://doi.org/10.1038/msb.2010.23 |
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