Hepatoprotective and Fat-Accumulation-Reductive Effects of Curcumin on Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)
Fat accumulation is the hallmark of metabolic dysfunction-associated steatotic liver disease (MASLD). Given the intimidating nature of its treatment, curcumin (CUR) emerges as a potential therapeutic agent due to its proven effectiveness in managing MASLD. This review aimed to evaluate previous repo...
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MDPI AG
2025-02-01
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| Series: | Current Issues in Molecular Biology |
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| Online Access: | https://www.mdpi.com/1467-3045/47/3/159 |
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| author | Jasmine Harumi Sabini Kris Herawan Timotius |
| author_facet | Jasmine Harumi Sabini Kris Herawan Timotius |
| author_sort | Jasmine Harumi Sabini |
| collection | DOAJ |
| description | Fat accumulation is the hallmark of metabolic dysfunction-associated steatotic liver disease (MASLD). Given the intimidating nature of its treatment, curcumin (CUR) emerges as a potential therapeutic agent due to its proven effectiveness in managing MASLD. This review aimed to evaluate previous reports on the hepatoprotective and fat-accumulation-reductive effects of CUR administration in preventing or treating MASLD. CUR administration can modulate serum liver enzymes and lipid profiles. The fat accumulation of MASLD is the primary cause of oxidative stress and inflammation. By reducing fat accumulation, CUR may attenuate the inflammation and oxidative stress in MASLD. In addition, CUR has been proven to restore the dysfunctional cellular energy metabolism capacity and attenuate fibrogenesis (antifibrotic agent). Their hepatoprotective effects are associated with fat accumulation in MASLD. Lipid metabolism (lipogenesis, lipolysis, and lipophagy) is correlated with their hepatoprotective effects. CUR has prophylactic and therapeutic effects, particularly in early-stage MASLD, primarily when it is used as a fat reducer. It can be considered an excellent natural therapeutic drug for MASLD because it protects the liver and attenuates fat accumulation, especially in the early stage of MASLD development. |
| format | Article |
| id | doaj-art-3a653ade82a94d03ab47a287ed3793ce |
| institution | Kabale University |
| issn | 1467-3037 1467-3045 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | MDPI AG |
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| series | Current Issues in Molecular Biology |
| spelling | doaj-art-3a653ade82a94d03ab47a287ed3793ce2025-08-20T03:43:30ZengMDPI AGCurrent Issues in Molecular Biology1467-30371467-30452025-02-0147315910.3390/cimb47030159Hepatoprotective and Fat-Accumulation-Reductive Effects of Curcumin on Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)Jasmine Harumi Sabini0Kris Herawan Timotius1Faculty of Medicine and Health Sciences, Krida Wacana Christian University, Jakarta 11510, IndonesiaFaculty of Medicine and Health Sciences, Krida Wacana Christian University, Jakarta 11510, IndonesiaFat accumulation is the hallmark of metabolic dysfunction-associated steatotic liver disease (MASLD). Given the intimidating nature of its treatment, curcumin (CUR) emerges as a potential therapeutic agent due to its proven effectiveness in managing MASLD. This review aimed to evaluate previous reports on the hepatoprotective and fat-accumulation-reductive effects of CUR administration in preventing or treating MASLD. CUR administration can modulate serum liver enzymes and lipid profiles. The fat accumulation of MASLD is the primary cause of oxidative stress and inflammation. By reducing fat accumulation, CUR may attenuate the inflammation and oxidative stress in MASLD. In addition, CUR has been proven to restore the dysfunctional cellular energy metabolism capacity and attenuate fibrogenesis (antifibrotic agent). Their hepatoprotective effects are associated with fat accumulation in MASLD. Lipid metabolism (lipogenesis, lipolysis, and lipophagy) is correlated with their hepatoprotective effects. CUR has prophylactic and therapeutic effects, particularly in early-stage MASLD, primarily when it is used as a fat reducer. It can be considered an excellent natural therapeutic drug for MASLD because it protects the liver and attenuates fat accumulation, especially in the early stage of MASLD development.https://www.mdpi.com/1467-3045/47/3/159fatty liverfibrogenesislipogenesislipophagylipolysisNAFLD |
| spellingShingle | Jasmine Harumi Sabini Kris Herawan Timotius Hepatoprotective and Fat-Accumulation-Reductive Effects of Curcumin on Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) Current Issues in Molecular Biology fatty liver fibrogenesis lipogenesis lipophagy lipolysis NAFLD |
| title | Hepatoprotective and Fat-Accumulation-Reductive Effects of Curcumin on Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) |
| title_full | Hepatoprotective and Fat-Accumulation-Reductive Effects of Curcumin on Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) |
| title_fullStr | Hepatoprotective and Fat-Accumulation-Reductive Effects of Curcumin on Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) |
| title_full_unstemmed | Hepatoprotective and Fat-Accumulation-Reductive Effects of Curcumin on Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) |
| title_short | Hepatoprotective and Fat-Accumulation-Reductive Effects of Curcumin on Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) |
| title_sort | hepatoprotective and fat accumulation reductive effects of curcumin on metabolic dysfunction associated steatotic liver disease masld |
| topic | fatty liver fibrogenesis lipogenesis lipophagy lipolysis NAFLD |
| url | https://www.mdpi.com/1467-3045/47/3/159 |
| work_keys_str_mv | AT jasmineharumisabini hepatoprotectiveandfataccumulationreductiveeffectsofcurcuminonmetabolicdysfunctionassociatedsteatoticliverdiseasemasld AT krisherawantimotius hepatoprotectiveandfataccumulationreductiveeffectsofcurcuminonmetabolicdysfunctionassociatedsteatoticliverdiseasemasld |