Association of Helicobacter pylori Infection with Glycemic Control in Patients with Diabetes: A Meta-Analysis
Objective. To assess the association between Helicobacter pylori (HP) infection and glycemic control in patients with diabetes through a meta-analytic approach. Research Design and Methods. Electronic literature searches were conducted for cross-sectional studies that examined the hemoglobin A1c (A1...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2014/250620 |
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| author | Chika Horikawa Satoru Kodama Kazuya Fujihara Yoko Yachi Shiro Tanaka Akiko Suzuki Osamu Hanyu Hitoshi Shimano Hirohito Sone |
| author_facet | Chika Horikawa Satoru Kodama Kazuya Fujihara Yoko Yachi Shiro Tanaka Akiko Suzuki Osamu Hanyu Hitoshi Shimano Hirohito Sone |
| author_sort | Chika Horikawa |
| collection | DOAJ |
| description | Objective. To assess the association between Helicobacter pylori (HP) infection and glycemic control in patients with diabetes through a meta-analytic approach. Research Design and Methods. Electronic literature searches were conducted for cross-sectional studies that examined the hemoglobin A1c (A1C) level by whether patients with diabetes were or were not carriers of HP. Mean differences in A1C between groups with and without HP infection were pooled with a random-effects model. Results. Thirteen eligible studies were included in this meta-analysis. Overall, the HP carriers did not have significantly higher A1C levels compared with HP noncarriers (mean difference (95% CI), 0.19% (−0.18 to 0.46), P = 0.16). When the analysis was limited to studies targeting patients with type 1 diabetes, there was also no significant difference in A1C (0.69% (−0.31 to 1.68), P = 0.18). Conclusions. There was insufficient evidence that HP infection worsened glycemic control in patients with diabetes. |
| format | Article |
| id | doaj-art-3a5e51b1320e414a8cd4aedd9536fc52 |
| institution | OA Journals |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-3a5e51b1320e414a8cd4aedd9536fc522025-08-20T02:07:46ZengWileyJournal of Diabetes Research2314-67452314-67532014-01-01201410.1155/2014/250620250620Association of Helicobacter pylori Infection with Glycemic Control in Patients with Diabetes: A Meta-AnalysisChika Horikawa0Satoru Kodama1Kazuya Fujihara2Yoko Yachi3Shiro Tanaka4Akiko Suzuki5Osamu Hanyu6Hitoshi Shimano7Hirohito Sone8Department of Health and Nutrition, Faculty of Human Life Studies, University of Niigata Prefecture, Niigata, JapanDepartment of Internal Medicine, Faculty of Medicine, Niigata University, 1-754 Asahimachi, Niigata 951-8510, JapanDepartment of Internal Medicine, Faculty of Medicine, Niigata University, 1-754 Asahimachi, Niigata 951-8510, JapanDepartment of Internal Medicine, Faculty of Medicine, Niigata University, 1-754 Asahimachi, Niigata 951-8510, JapanDepartment of Clinical Trial, Design & Management, Translational Research Center, Kyoto University Hospital, Kyoto, JapanDepartment of Internal Medicine, Faculty of Medicine, Niigata University, 1-754 Asahimachi, Niigata 951-8510, JapanDepartment of Internal Medicine, Faculty of Medicine, Niigata University, 1-754 Asahimachi, Niigata 951-8510, JapanDepartment of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, JapanDepartment of Internal Medicine, Faculty of Medicine, Niigata University, 1-754 Asahimachi, Niigata 951-8510, JapanObjective. To assess the association between Helicobacter pylori (HP) infection and glycemic control in patients with diabetes through a meta-analytic approach. Research Design and Methods. Electronic literature searches were conducted for cross-sectional studies that examined the hemoglobin A1c (A1C) level by whether patients with diabetes were or were not carriers of HP. Mean differences in A1C between groups with and without HP infection were pooled with a random-effects model. Results. Thirteen eligible studies were included in this meta-analysis. Overall, the HP carriers did not have significantly higher A1C levels compared with HP noncarriers (mean difference (95% CI), 0.19% (−0.18 to 0.46), P = 0.16). When the analysis was limited to studies targeting patients with type 1 diabetes, there was also no significant difference in A1C (0.69% (−0.31 to 1.68), P = 0.18). Conclusions. There was insufficient evidence that HP infection worsened glycemic control in patients with diabetes.http://dx.doi.org/10.1155/2014/250620 |
| spellingShingle | Chika Horikawa Satoru Kodama Kazuya Fujihara Yoko Yachi Shiro Tanaka Akiko Suzuki Osamu Hanyu Hitoshi Shimano Hirohito Sone Association of Helicobacter pylori Infection with Glycemic Control in Patients with Diabetes: A Meta-Analysis Journal of Diabetes Research |
| title | Association of Helicobacter pylori Infection with Glycemic Control in Patients with Diabetes: A Meta-Analysis |
| title_full | Association of Helicobacter pylori Infection with Glycemic Control in Patients with Diabetes: A Meta-Analysis |
| title_fullStr | Association of Helicobacter pylori Infection with Glycemic Control in Patients with Diabetes: A Meta-Analysis |
| title_full_unstemmed | Association of Helicobacter pylori Infection with Glycemic Control in Patients with Diabetes: A Meta-Analysis |
| title_short | Association of Helicobacter pylori Infection with Glycemic Control in Patients with Diabetes: A Meta-Analysis |
| title_sort | association of helicobacter pylori infection with glycemic control in patients with diabetes a meta analysis |
| url | http://dx.doi.org/10.1155/2014/250620 |
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