Evaluation of LVAD infections in a tertiary university hospital cohort
AIM: This study aims to evaluate driveline infections in ourcenter in terms of pathogens and resistance patterns. BACKGROUND: The use of left ventricular assist devices (LVAD) is increasing for bridging therapy inpatients who cannot undergo heart transplantation or for long-term therapy in patients...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-12-01
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| Series: | Journal of Global Antimicrobial Resistance |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213716524003175 |
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| author | Ümit Kahraman Oğuzhan Acet Hasip Kahraman Muhammed Alper Özarslan Derya Kaya Oğuz Reşat Sipahi Meltem Taşbakan Mustafa Özbaran Tahir Yağdıç Çağatay Engin |
| author_facet | Ümit Kahraman Oğuzhan Acet Hasip Kahraman Muhammed Alper Özarslan Derya Kaya Oğuz Reşat Sipahi Meltem Taşbakan Mustafa Özbaran Tahir Yağdıç Çağatay Engin |
| author_sort | Ümit Kahraman |
| collection | DOAJ |
| description | AIM: This study aims to evaluate driveline infections in ourcenter in terms of pathogens and resistance patterns. BACKGROUND: The use of left ventricular assist devices (LVAD) is increasing for bridging therapy inpatients who cannot undergo heart transplantation or for long-term therapy in patients who are not suitable for heart transplantation. The most common complication after LVAD implantation is driveline infections. METHODS: We retrospectively evaluated LVAD patients implanted at our center between 01.01.2010 and 20.11.2023. Patients with drive-line infection findings and microbiological growth in the drive-line exit site culture were included in the study. Microbiological culture wgrowths, bacteremia rates, and resistance patterns of pathogens were evaluated. RESULTS: LVAD implantation was performed in 124 patients between the specified dates. In 109 patients [21 women (19.2%), mean age 50.9±12.45, years ranging 18-71], culture growth, which can be associated with LVAD,was observed in the drive-line exit site (n:94-86.2%), peripheral blood culture (55-50.4%), or both (52-47.7%). In 57 (52.2%) patients,multiple microorganisms were grown in the culture of the driveline exit area.In 15 (13.7%) patients, multiple microorganisms were grown in the peripheral blood cultures. The microorganisms are shown in Table 1.Etiological agents and resistance patterns of the microorganisms are shown in Table 2. During the follow-up period, the swab culture growths of 52 patients and the peripheral blood culture of 41 patients were eradicated. The five-year survival rate after LVAD implantation was 58/109(53.2%). CONCLUSIONS: LVAD-associated infections and antibiotic-resistant microorganisms are common in LVAD-implanted patients. When choosing antibiotics for LVAD-related infections, it is important to consider local hospital information. |
| format | Article |
| id | doaj-art-3a5b3312c0cb4cc9a8d13263ef2454c4 |
| institution | DOAJ |
| issn | 2213-7165 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Global Antimicrobial Resistance |
| spelling | doaj-art-3a5b3312c0cb4cc9a8d13263ef2454c42025-08-20T02:53:21ZengElsevierJournal of Global Antimicrobial Resistance2213-71652024-12-0139434410.1016/j.jgar.2024.10.140Evaluation of LVAD infections in a tertiary university hospital cohortÜmit Kahraman0Oğuzhan Acet1Hasip Kahraman2Muhammed Alper Özarslan3Derya Kaya4Oğuz Reşat Sipahi5Meltem Taşbakan6Mustafa Özbaran7Tahir Yağdıç8Çağatay Engin9Department of Cardiovascular Surgery, Ege University, İzmir, TurkiyeDepartment of Infectious Diseases and Clinical Microbiology, Ege University, İzmir, TurkiyeDepartment of Infectious Diseases and Clinical Microbiology, Eskişehir Osmangazi University, Eskişehir, TurkiyeDepartment of Medical Microbiology, Ege University, İzmir, TurkiyeDepartment of Infectious Diseases and Clinical Microbiology, Ege University, İzmir, TurkiyeDepartment of Infectious Diseases and Clinical Microbiology, Ege University, İzmir, TurkiyeDepartment of Infectious Diseases and Clinical Microbiology, Ege University, İzmir, TurkiyeDepartment of Cardiovascular Surgery, Ege University, İzmir, TurkiyeDepartment of Cardiovascular Surgery, Ege University, İzmir, TurkiyeDepartment of Cardiovascular Surgery, Ege University, İzmir, TurkiyeAIM: This study aims to evaluate driveline infections in ourcenter in terms of pathogens and resistance patterns. BACKGROUND: The use of left ventricular assist devices (LVAD) is increasing for bridging therapy inpatients who cannot undergo heart transplantation or for long-term therapy in patients who are not suitable for heart transplantation. The most common complication after LVAD implantation is driveline infections. METHODS: We retrospectively evaluated LVAD patients implanted at our center between 01.01.2010 and 20.11.2023. Patients with drive-line infection findings and microbiological growth in the drive-line exit site culture were included in the study. Microbiological culture wgrowths, bacteremia rates, and resistance patterns of pathogens were evaluated. RESULTS: LVAD implantation was performed in 124 patients between the specified dates. In 109 patients [21 women (19.2%), mean age 50.9±12.45, years ranging 18-71], culture growth, which can be associated with LVAD,was observed in the drive-line exit site (n:94-86.2%), peripheral blood culture (55-50.4%), or both (52-47.7%). In 57 (52.2%) patients,multiple microorganisms were grown in the culture of the driveline exit area.In 15 (13.7%) patients, multiple microorganisms were grown in the peripheral blood cultures. The microorganisms are shown in Table 1.Etiological agents and resistance patterns of the microorganisms are shown in Table 2. During the follow-up period, the swab culture growths of 52 patients and the peripheral blood culture of 41 patients were eradicated. The five-year survival rate after LVAD implantation was 58/109(53.2%). CONCLUSIONS: LVAD-associated infections and antibiotic-resistant microorganisms are common in LVAD-implanted patients. When choosing antibiotics for LVAD-related infections, it is important to consider local hospital information.http://www.sciencedirect.com/science/article/pii/S2213716524003175Left Ventricular Assist DeviceHeart FailureDriveline Infections |
| spellingShingle | Ümit Kahraman Oğuzhan Acet Hasip Kahraman Muhammed Alper Özarslan Derya Kaya Oğuz Reşat Sipahi Meltem Taşbakan Mustafa Özbaran Tahir Yağdıç Çağatay Engin Evaluation of LVAD infections in a tertiary university hospital cohort Journal of Global Antimicrobial Resistance Left Ventricular Assist Device Heart Failure Driveline Infections |
| title | Evaluation of LVAD infections in a tertiary university hospital cohort |
| title_full | Evaluation of LVAD infections in a tertiary university hospital cohort |
| title_fullStr | Evaluation of LVAD infections in a tertiary university hospital cohort |
| title_full_unstemmed | Evaluation of LVAD infections in a tertiary university hospital cohort |
| title_short | Evaluation of LVAD infections in a tertiary university hospital cohort |
| title_sort | evaluation of lvad infections in a tertiary university hospital cohort |
| topic | Left Ventricular Assist Device Heart Failure Driveline Infections |
| url | http://www.sciencedirect.com/science/article/pii/S2213716524003175 |
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