Use of hypofractionated radiotherapy regimens after organ-sparing surgery for Stages I–IIA breast cancers

There have been recent reports on the expediency of applying postoperative hypofractionated accelerated radiotherapy (RT) regimens in patients who have undergone breast-sparing surgery. The concept of accelerated hypofractionation (AH) includes daily high-dose radiation for a shorter total period of...

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Bibliographic Details
Main Authors: Yu. V. Efimkina, I. A. Gladilina, M. I. Nechushkin
Format: Article
Language:Russian
Published: ABV-press 2014-08-01
Series:Опухоли женской репродуктивной системы
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Online Access:https://ojrs.abvpress.ru/ojrs/article/view/225
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Summary:There have been recent reports on the expediency of applying postoperative hypofractionated accelerated radiotherapy (RT) regimens in patients who have undergone breast-sparing surgery. The concept of accelerated hypofractionation (AH) includes daily high-dose radiation for a shorter total period of time. In most radiologists’ opinion, the AH RT regimen may be as effective as more conventional treatments that use lower daily radiation doses for a longer period. The appeal of this method is that shorter treatment provides more convenience for patients. By taking into account the fact that the α/β ratio for intact breast tissues is about 3.5 Gy, larger fraction RT regi- mens are likely to be more effective, which will reduce the frequency of recurrences as compared with conventional therapy approaches without increasing the incidence of postradiation intact tissue damage.
ISSN:1994-4098
1999-8627